Minimally disruptive optical control of protein tyrosine phosphatase 1B.


:Protein tyrosine phosphatases regulate a myriad of essential subcellular signaling events, yet they remain difficult to study in their native biophysical context. Here we develop a minimally disruptive optical approach to control protein tyrosine phosphatase 1B (PTP1B)-an important regulator of receptor tyrosine kinases and a therapeutic target for the treatment of diabetes, obesity, and cancer-and we use that approach to probe the intracellular function of this enzyme. Our conservative architecture for photocontrol, which consists of a protein-based light switch fused to an allosteric regulatory element, preserves the native structure, activity, and subcellular localization of PTP1B, affords changes in activity that match those elicited by post-translational modifications inside the cell, and permits experimental analyses of the molecular basis of optical modulation. Findings indicate, most strikingly, that small changes in the activity of PTP1B can cause large shifts in the phosphorylation states of its regulatory targets.


Nat Commun


Nature communications


Hongdusit A,Zwart PH,Sankaran B,Fox JM




Has Abstract


2020-02-07 00:00:00












  • Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.

    abstract::CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

    更新日期:2016-02-04 00:00:00

  • Biogenic volatile release from permafrost thaw is determined by the soil microbial sink.

    abstract::Warming in the Arctic accelerates thawing of permafrost-affected soils, which leads to a release of greenhouse gases to the atmosphere. We do not know whether permafrost thaw also releases non-methane volatile organic compounds that can contribute to both negative and positive radiative forcing on climate. Here we sho...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kramshøj M,Albers CN,Holst T,Holzinger R,Elberling B,Rinnan R

    更新日期:2018-08-24 00:00:00

  • Unconventional slowing down of electronic recovery in photoexcited charge-ordered La1/3Sr2/3FeO3.

    abstract::The coupling of ordered electronic phases with lattice, spin, and orbital degrees of freedom are of central interest in strongly correlated systems. Their interplay has been intensively studied from femtosecond to picosecond time scales, while their dynamics beyond nanoseconds are usually assumed to follow lattice coo...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zhu Y,Hoffman J,Rowland CE,Park H,Walko DA,Freeland JW,Ryan PJ,Schaller RD,Bhattacharya A,Wen H

    更新日期:2018-05-04 00:00:00

  • In-situ visualization of the space-charge-layer effect on interfacial lithium-ion transport in all-solid-state batteries.

    abstract::The space charge layer (SCL) is generally considered one of the origins of the sluggish interfacial lithium-ion transport in all-solid-state lithium-ion batteries (ASSLIBs). However, in-situ visualization of the SCL effect on the interfacial lithium-ion transport in sulfide-based ASSLIBs is still a great challenge. He...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Wang L,Xie R,Chen B,Yu X,Ma J,Li C,Hu Z,Sun X,Xu C,Dong S,Chan TS,Luo J,Cui G,Chen L

    更新日期:2020-11-18 00:00:00

  • Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory.

    abstract::Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to function as competitive endogenous RNAs (ceRNAs) by sponging specific microRNAs. Here, we report the first spatially resolved cellular expr...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kristensen LS,Ebbesen KK,Sokol M,Jakobsen T,Korsgaard U,Eriksen AC,Hansen TB,Kjems J,Hager H

    更新日期:2020-09-11 00:00:00

  • An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells.

    abstract::Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel wi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Shen S,Faouzi S,Bastide A,Martineau S,Malka-Mahieu H,Fu Y,Sun X,Mateus C,Routier E,Roy S,Desaubry L,André F,Eggermont A,David A,Scoazec JY,Vagner S,Robert C

    更新日期:2019-12-16 00:00:00

  • Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.

    abstract::Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapidly metabolized and...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Gray DL,Allen JA,Mente S,O'Connor RE,DeMarco GJ,Efremov I,Tierney P,Volfson D,Davoren J,Guilmette E,Salafia M,Kozak R,Ehlers MD

    更新日期:2018-02-14 00:00:00

  • Publisher Correction: CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 已发布勘误


    authors: Luo Y,Teng X,Zhang L,Chen J,Liu Z,Chen X,Zhao S,Yang S,Feng J,Yan X

    更新日期:2019-09-05 00:00:00

  • Methane seep carbonates yield clumped isotope signatures out of equilibrium with formation temperatures.

    abstract::Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Loyd SJ,Sample J,Tripati RE,Defliese WF,Brooks K,Hovland M,Torres M,Marlow J,Hancock LG,Martin R,Lyons T,Tripati AE

    更新日期:2016-07-22 00:00:00

  • Towards full-colour tunability of inorganic electrochromic devices using ultracompact fabry-perot nanocavities.

    abstract::Intercalation-based inorganic materials that change their colours upon ion insertion/extraction lay an important foundation for existing electrochromic technology. However, using only such inorganic electrochromic materials, it is very difficult to achieve the utmost goal of full-colour tunability for future electroch...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Wang Z,Wang X,Cong S,Chen J,Sun H,Chen Z,Song G,Geng F,Chen Q,Zhao Z

    更新日期:2020-01-16 00:00:00

  • Chromatin remodeling in bovine embryos indicates species-specific regulation of genome activation.

    abstract::The shift from maternal to embryonic control is a critical developmental milestone in preimplantation development. Widespread transcriptomic and epigenetic remodeling facilitate this transition from terminally differentiated gametes to totipotent blastomeres, but the identity of transcription factors (TF) and genomic ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Halstead MM,Ma X,Zhou C,Schultz RM,Ross PJ

    更新日期:2020-09-17 00:00:00

  • Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation.

    abstract::Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. The factors that induce these changes remain unknown. Conversely, functional recovery following...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Cisterna BA,Vargas AA,Puebla C,Fernández P,Escamilla R,Lagos CF,Matus MF,Vilos C,Cea LA,Barnafi E,Gaete H,Escobar DF,Cardozo CP,Sáez JC

    更新日期:2020-02-26 00:00:00

  • FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation.

    abstract::FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser552, and promotes its...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Yang F,Xu J,Li H,Tan M,Xiong X,Sun Y

    更新日期:2019-03-27 00:00:00

  • Indole is an essential herbivore-induced volatile priming signal in maize.

    abstract::Herbivore-induced volatile organic compounds prime non-attacked plant tissues to respond more strongly to subsequent attacks. However, the key volatiles that trigger this primed state remain largely unidentified. In maize, the release of the aromatic compound indole is herbivore-specific and occurs earlier than other ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Erb M,Veyrat N,Robert CA,Xu H,Frey M,Ton J,Turlings TC

    更新日期:2015-02-16 00:00:00

  • Surveying biomolecular frustration at atomic resolution.

    abstract::To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Chen M,Chen X,Schafer NP,Clementi C,Komives EA,Ferreiro DU,Wolynes PG

    更新日期:2020-11-23 00:00:00

  • Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.

    abstract::Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon cancer and confirmation in other cancer models, here we determin...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Xiang W,Shi R,Kang X,Zhang X,Chen P,Zhang L,Hou A,Wang R,Zhao Y,Zhao K,Liu Y,Ma Y,Luo H,Shang S,Zhang J,He F,Yu S,Gan L,Shi C,Li Y,Yang W,Liang H,Miao H

    更新日期:2018-07-03 00:00:00

  • Blocking transport resonances via Kondo many-body entanglement in quantum dots.

    abstract::Many-body entanglement is at the heart of the Kondo effect, which has its hallmark in quantum dots as a zero-bias conductance peak at low temperatures. It signals the emergence of a conducting singlet state formed by a localized dot degree of freedom and conduction electrons. Carbon nanotubes offer the possibility to ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Niklas M,Smirnov S,Mantelli D,Margańska M,Nguyen NV,Wernsdorfer W,Cleuziou JP,Grifoni M

    更新日期:2016-08-16 00:00:00

  • Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation.

    abstract::CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Wang L,Liu R,Ye P,Wong C,Chen GY,Zhou P,Sakabe K,Zheng X,Wu W,Zhang P,Jiang T,Bassetti MF,Jube S,Sun Y,Zhang Y,Zheng P,Liu Y

    更新日期:2015-01-20 00:00:00

  • On quantum gravity tests with composite particles.

    abstract::Models of quantum gravity imply a fundamental revision of our description of position and momentum that manifests in modifications of the canonical commutation relations. Experimental tests of such modifications remain an outstanding challenge. These corrections scale with the mass of test particles, which motivates e...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kumar SP,Plenio MB

    更新日期:2020-08-06 00:00:00

  • Terahertz-driven linear electron acceleration.

    abstract::The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30-50 MeV m(-1) gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Nanni EA,Huang WR,Hong KH,Ravi K,Fallahi A,Moriena G,Miller RJ,Kärtner FX

    更新日期:2015-10-06 00:00:00

  • Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital.

    abstract::Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Garcia-Basteiro AL,Moncunill G,Tortajada M,Vidal M,Guinovart C,Jiménez A,Santano R,Sanz S,Méndez S,Llupià A,Aguilar R,Alonso S,Barrios D,Carolis C,Cisteró P,Chóliz E,Cruz A,Fochs S,Jairoce C,Hecht J,Lamoglia M,M

    更新日期:2020-07-08 00:00:00

  • Compositional boundary layers trigger liquid unmixing in a basaltic crystal mush.

    abstract::The separation of immiscible liquids has significant implications for magma evolution and the formation of magmatic ore deposits. We combine high-resolution imaging and electron probe microanalysis with the first use of atom probe tomography on tholeiitic basaltic glass from Hawaii, the Snake River Plain, and Iceland,...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Honour VC,Holness MB,Charlier B,Piazolo SC,Namur O,Prosa TJ,Martin I,Helz RT,Maclennan J,Jean MM

    更新日期:2019-10-23 00:00:00

  • Dispersion relation of the collective excitations in a resonantly driven polariton fluid.

    abstract::Exciton-polaritons in semiconductor microcavities constitute the archetypal realization of a quantum fluid of light. Under coherent optical drive, remarkable effects such as superfluidity, dark solitons or the nucleation of vortices have been observed, and can be all understood as specific manifestations of the conden...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Stepanov P,Amelio I,Rousset JG,Bloch J,Lemaître A,Amo A,Minguzzi A,Carusotto I,Richard M

    更新日期:2019-08-27 00:00:00

  • Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition.

    abstract::Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

    更新日期:2020-05-15 00:00:00

  • Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking.

    abstract::Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking sign...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Chen S,Augustine GJ,Chadderton P

    更新日期:2017-08-10 00:00:00

  • Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.

    abstract::Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Nakamura S,Karalay Ö,Jäger PS,Horikawa M,Klein C,Nakamura K,Latza C,Templer SE,Dieterich C,Antebi A

    更新日期:2016-03-22 00:00:00

  • Author Correction: The Seminavis robusta genome provides insights into the evolutionary adaptations of benthic diatoms.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 已发布勘误


    authors: Osuna-Cruz CM,Bilcke G,Vancaester E,De Decker S,Bones AM,Winge P,Poulsen N,Bulankova P,Verhelst B,Audoor S,Belisova D,Pargana A,Russo M,Stock F,Cirri E,Brembu T,Pohnert G,Piganeau G,Ferrante MI,Mock T,Sterck L,S

    更新日期:2020-10-16 00:00:00

  • High-performance rechargeable lithium-iodine batteries using triiodide/iodide redox couples in an aqueous cathode.

    abstract::Development of promising battery systems is being intensified to fulfil the needs of long-driving-ranged electric vehicles. The successful candidates for new generation batteries should have higher energy densities than those of currently used batteries and reasonable rechargeability. Here we report that aqueous lithi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zhao Y,Wang L,Byon HR

    更新日期:2013-01-01 00:00:00

  • Synergistic effect of quinary molten salts and ruthenium catalyst for high-power-density lithium-carbon dioxide cell.

    abstract::With a recent increase in interest in metal-gas batteries, the lithium-carbon dioxide cell has attracted considerable attention because of its extraordinary carbon dioxide-capture ability during the discharge process and its potential application as a power source for Mars exploration. However, owing to the stable lit...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Baek K,Jeon WC,Woo S,Kim JC,Lee JG,An K,Kwak SK,Kang SJ

    更新日期:2020-01-23 00:00:00

  • Regional boreal biodiversity peaks at intermediate human disturbance.

    abstract::The worldwide biodiversity crisis has intensified the need to better understand how biodiversity and human disturbance are related. The 'intermediate disturbance hypothesis' suggests that disturbance regimes generate predictable non-linear patterns in species richness. Evidence often contradicts intermediate disturban...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Mayor SJ,Cahill JF Jr,He F,Sólymos P,Boutin S

    更新日期:2012-01-01 00:00:00