Trunk exoskeleton in teleosts is mesodermal in origin.

abstract：:Many decisions are based on an internal model of the world. Yet, how such a model is constructed from experience and represented in memory remains unknown. We test the hypothesis that reward shapes memory for sequences of events by retroactively prioritizing memory for objects as a function of their distance from rewa...

journal_title：Nature communications

authors： Braun EK,Wimmer GE,Shohamy D

更新日期：2018-11-20 00:00:00

abstract：:Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are poorly understood. Here we show that PI3Kα regulates endothelial cell rearrangements using a combination of a PI3Kα-selective inhibitor and endothelial-specific...

journal_title：Nature communications

authors： Angulo-Urarte A,Casado P,Castillo SD,Kobialka P,Kotini MP,Figueiredo AM,Castel P,Rajeeve V,Milà-Guasch M,Millan J,Wiesner C,Serra H,Muixi L,Casanovas O,Viñals F,Affolter M,Gerhardt H,Huveneers S,Belting HG,Cutillas

更新日期：2018-11-16 00:00:00

abstract：:Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing rel...

journal_title：Nature communications

authors： Condon MD,Platt NJ,Zhang YF,Roberts BM,Clements MA,Vietti-Michelina S,Tseu MY,Brimblecombe KR,Threlfell S,Mann EO,Cragg SJ

更新日期：2019-09-19 00:00:00

abstract：:Nonsense-mediated decay (NMD) eliminates transcripts with premature termination codons. Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional consequence in tumours has not been characterized. Here we develop an algorithm to predict NMD and apply...

journal_title：Nature communications

authors： Hu Z,Yau C,Ahmed AA

更新日期：2017-06-26 00:00:00

abstract：:TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contrast to its closest s...

journal_title：Nature communications

authors： Demircioglu FE,Zheng W,McQuown AJ,Maier NK,Watson N,Cheeseman IM,Denic V,Egelman EH,Schwartz TU

更新日期：2019-07-22 00:00:00

abstract：:Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation, an effect that causes spectral corruption. Spectral corruption has limited the quantification accuracy of optical and optoacoustic spectroscopic methods, and impeded the goal of imaging blood oxyge...

journal_title：Nature communications

authors： Tzoumas S,Nunes A,Olefir I,Stangl S,Symvoulidis P,Glasl S,Bayer C,Multhoff G,Ntziachristos V

更新日期：2016-06-30 00:00:00

abstract：:A planar slab of negative-index material works as a superlens with sub-diffraction-limited resolution, as propagating waves are focused and, moreover, evanescent waves are reconstructed in the image plane. Here we demonstrate a superlens for electric evanescent fields with low losses using perovskites in the mid-infra...

journal_title：Nature communications

authors： Kehr SC,Liu YM,Martin LW,Yu P,Gajek M,Yang SY,Yang CH,Wenzel MT,Jacob R,von Ribbeck HG,Helm M,Zhang X,Eng LM,Ramesh R

更新日期：2011-01-01 00:00:00

abstract：:Polar van der Waals chalcogenophosphates exhibit unique properties, such as negative electrostriction and multi-well ferrielectricity, and enable combining dielectric and 2D electronic materials. Using low temperature piezoresponse force microscopy, we revealed coexistence of piezoelectric and non-piezoelectric phases...

journal_title：Nature communications

authors： Dziaugys A,Kelley K,Brehm JA,Tao L,Puretzky A,Feng T,O'Hara A,Neumayer S,Chyasnavichyus M,Eliseev EA,Banys J,Vysochanskii Y,Ye F,Chakoumakos BC,Susner MA,McGuire MA,Kalinin SV,Ganesh P,Balke N,Pantelides ST,Morozo

更新日期：2020-07-17 00:00:00

abstract：:Optimal decision-making employs short-term rewards and abstract long-term information based on which of these is deemed relevant. Employing short- vs. long-term information is associated with different learning mechanisms, yet neural evidence showing that these two are dissociable is lacking. Here we demonstrate that ...

journal_title：Nature communications

authors： Fischer AG,Bourgeois-Gironde S,Ullsperger M

更新日期：2017-11-22 00:00:00

abstract：:Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing c...

journal_title：Nature communications

authors： Watson SA,Duff J,Bardi I,Zabielska M,Atanur SS,Jabbour RJ,Simon A,Tomas A,Smolenski RT,Harding SE,Perbellini F,Terracciano CM

更新日期：2019-05-15 00:00:00

abstract：:Diamond photonics is an ever-growing field of research driven by the prospects of harnessing diamond and its colour centres as suitable hardware for solid-state quantum applications. The last two decades have seen the field shaped by the nitrogen-vacancy (NV) centre with both breakthrough fundamental physics demonstra...

journal_title：Nature communications

authors： Bradac C,Gao W,Forneris J,Trusheim ME,Aharonovich I

更新日期：2019-12-09 00:00:00

abstract：:Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons ...

journal_title：Nature communications

authors： Barry DM,Liu XT,Liu B,Liu XY,Gao F,Zeng X,Liu J,Yang Q,Wilhelm S,Yin J,Tao A,Chen ZF

更新日期：2020-03-13 00:00:00

abstract：:The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumour cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site. WC-21, a sigma-2 ligand containing both a photoactive azide moiety and a fluorescein isoth...

journal_title：Nature communications

authors： Xu J,Zeng C,Chu W,Pan F,Rothfuss JM,Zhang F,Tu Z,Zhou D,Zeng D,Vangveravong S,Johnston F,Spitzer D,Chang KC,Hotchkiss RS,Hawkins WG,Wheeler KT,Mach RH

更新日期：2011-07-05 00:00:00

abstract：:In 2016 the World Health Organization identified 21 countries that could eliminate malaria by 2020. Monitoring progress towards this goal requires tracking ongoing transmission. Here we develop methods that estimate individual reproduction numbers and their variation through time and space. Individual reproduction num...

journal_title：Nature communications

authors： Routledge I,Chevéz JER,Cucunubá ZM,Rodriguez MG,Guinovart C,Gustafson KB,Schneider K,Walker PGT,Ghani AC,Bhatt S

更新日期：2018-06-26 00:00:00

abstract：:Viruses cause 10-15% of all human cancers. Massively parallel sequencing has recently proved effective for uncovering novel viruses and virus-tumour associations, but this approach has not yet been applied to comprehensive patient cohorts. Here we screen a diverse landscape of human cancer, encompassing 4,433 tumours ...

journal_title：Nature communications

authors： Tang KW,Alaei-Mahabadi B,Samuelsson T,Lindh M,Larsson E

更新日期：2013-01-01 00:00:00

abstract：:Separation of C2H4 from C2H4/C2H2/C2H6 mixture with high working capacity is still a challenging task. Herein, we deliberately design a Th-metal-organic framework (MOF) for highly efficient separation of C2H4 from a binary C2H6/C2H4 and ternary C2H4/C2H2/C2H6 mixture. The synthesized MOF Azole-Th-1 shows a UiO-66-type...

journal_title：Nature communications

authors： Xu Z,Xiong X,Xiong J,Krishna R,Li L,Fan Y,Luo F,Chen B

更新日期：2020-06-22 00:00:00

abstract：:Disordered mechanical systems, when strongly deformed, have complex configuration spaces with multiple stable states and pathways connecting them. The topology of such pathways determines which states are smoothly accessible from any part of configuration space. Controlling this topology would allow us to limit access...

journal_title：Nature communications

authors： Stern M,Jayaram V,Murugan A

更新日期：2018-10-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Wu X,Makineni SK,Liebscher CH,Dehm G,Mianroodi JR,Shanthraj P,Svendsen B,Bürger D,Eggeler G,Raabe D,Gault B

更新日期：2020-02-21 00:00:00

abstract：:Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here we report that coordinated mesenchymal cell migration during chicken feather elongation is accompanied by dynamic changes of bioelectric currents...

journal_title：Nature communications

authors： Li A,Cho JH,Reid B,Tseng CC,He L,Tan P,Yeh CY,Wu P,Li Y,Widelitz RB,Zhou Y,Zhao M,Chow RH,Chuong CM

更新日期：2018-12-18 00:00:00

abstract：:Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...

journal_title：Nature communications

authors： Mitrofanova A,Mallela SK,Ducasa GM,Yoo TH,Rosenfeld-Gur E,Zelnik ID,Molina J,Varona Santos J,Ge M,Sloan A,Kim JJ,Pedigo C,Bryn J,Volosenco I,Faul C,Zeidan YH,Garcia Hernandez C,Mendez AJ,Leibiger I,Burke GW,Futerm

更新日期：2019-06-19 00:00:00

abstract：:Designing highly durable and active electrocatalysts applied in polymer electrolyte membrane (PEM) electrolyzer for the oxygen evolution reaction remains a grand challenge due to the high dissolution of catalysts in acidic electrolyte. Hindering formation of oxygen vacancies by tuning the electronic structure of catal...

journal_title：Nature communications

authors： Hao S,Liu M,Pan J,Liu X,Tan X,Xu N,He Y,Lei L,Zhang X

更新日期：2020-10-23 00:00:00

abstract：:Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment of allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some of the limitations associated with the clinical use of the therapeutic anti-IgE antibody, omalizumab. H...

journal_title：Nature communications

authors： Gasser P,Tarchevskaya SS,Guntern P,Brigger D,Ruppli R,Zbären N,Kleinboelting S,Heusser C,Jardetzky TS,Eggel A

更新日期：2020-01-08 00:00:00

abstract：:Electron-positron pair plasmas represent a unique state of matter, whereby there exists an intrinsic and complete symmetry between negatively charged (matter) and positively charged (antimatter) particles. These plasmas play a fundamental role in the dynamics of ultra-massive astrophysical objects and are believed to ...

journal_title：Nature communications

authors： Sarri G,Poder K,Cole JM,Schumaker W,Di Piazza A,Reville B,Dzelzainis T,Doria D,Gizzi LA,Grittani G,Kar S,Keitel CH,Krushelnick K,Kuschel S,Mangles SP,Najmudin Z,Shukla N,Silva LO,Symes D,Thomas AG,Vargas M,Vieir

更新日期：2015-04-23 00:00:00

abstract：:Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that kinase activity of recepto...

journal_title：Nature communications

authors： Zhang Y,Su SS,Zhao S,Yang Z,Zhong CQ,Chen X,Cai Q,Yang ZH,Huang D,Wu R,Han J

更新日期：2017-02-08 00:00:00

abstract：:Most seafloor hydrothermal circulation occurs far from the magmatic influence of mid-ocean ridges, driving large flows of water, heat and solutes through volcanic rock outcrops on ridge flanks. Here we create three-dimensional simulations of ridge-flank hydrothermal circulation, flowing between and through seamounts, ...

journal_title：Nature communications

authors： Winslow DM,Fisher AT

更新日期：2015-06-26 00:00:00

abstract：:The lack of microbial genomes and isolates from the deep seabed means that very little is known about the ecology of this vast habitat. Here, we investigate energy and carbon acquisition strategies of microbial communities from three deep seabed petroleum seeps (3 km water depth) in the Eastern Gulf of Mexico. Shotgun...

journal_title：Nature communications

authors： Dong X,Greening C,Rattray JE,Chakraborty A,Chuvochina M,Mayumi D,Dolfing J,Li C,Brooks JM,Bernard BB,Groves RA,Lewis IA,Hubert CRJ

更新日期：2019-04-18 00:00:00

abstract：:Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together wit...

journal_title：Nature communications

authors： Capozzi A,Cheng T,Boero G,Roussel C,Comment A

更新日期：2017-06-01 00:00:00

abstract：:A number of marine organisms use muscle-controlled surface structures to achieve rapid changes in colour and transparency with outstanding reversibility. Inspired by these display tactics, we develop analogous deformation-controlled surface-engineering approaches via strain-dependent cracks and folds to realize the fo...

journal_title：Nature communications

authors： Zeng S,Zhang D,Huang W,Wang Z,Freire SG,Yu X,Smith AT,Huang EY,Nguon H,Sun L

更新日期：2016-07-08 00:00:00

abstract：:In most metazoan nuclei, heterochromatin is located at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to the nucleus. We show that in cultured cells, chromatin decompaction by the nucleosome binding protein HMGN5 decreases the sturdiness, elasticity and rigidity of the nu...

journal_title：Nature communications

authors： Furusawa T,Rochman M,Taher L,Dimitriadis EK,Nagashima K,Anderson S,Bustin M

更新日期：2015-01-22 00:00:00

abstract：:Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We...

journal_title：Nature communications

authors： Zhao LH,Liu X,Yan HX,Li WY,Zeng X,Yang Y,Zhao J,Liu SP,Zhuang XH,Lin C,Qin CJ,Zhao Y,Pan ZY,Huang G,Liu H,Zhang J,Wang RY,Yang Y,Wen W,Lv GS,Zhang HL,Wu H,Huang S,Wang MD,Tang L,Cao HZ,Wang L,Lee TL

更新日期：2016-10-05 00:00:00