Abstract:
:Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ionized by the head of the drive beam, in which case the distance of acceleration and energy gain can be strongly limited by head erosion. Here we overcome this limit and demonstrate that electrons in the tail of a drive beam can be accelerated by up to 27 GeV in a high-ionization-potential gas (argon), boosting their initial 20.35 GeV energy by 130%. Particle-in-cell simulations show that the argon plasma is sustaining very high electric fields, of ∼150 GV m(-1), over ∼20 cm. The results open new possibilities for the design of particle beam drivers and plasma sources.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Corde S,Adli E,Allen JM,An W,Clarke CI,Clausse B,Clayton CE,Delahaye JP,Frederico J,Gessner S,Green SZ,Hogan MJ,Joshi C,Litos M,Lu W,Marsh KA,Mori WB,Vafaei-Najafabadi N,Walz D,Yakimenko Vdoi
10.1038/ncomms11898subject
Has Abstractpub_date
2016-06-17 00:00:00pages
11898issn
2041-1723pii
ncomms11898journal_volume
7pub_type
杂志文章abstract::Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initiall...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12980-2
更新日期:2019-11-01 00:00:00
abstract::Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05346-7
更新日期:2018-07-27 00:00:00
abstract::Majority of disease-modifying therapeutic targets are restricted to the intracellular space and are therefore not druggable using existing biologic modalities. The ability to efficiently deliver macromolecules inside target cells or tissues would greatly expand the current landscape of therapeutic targets for future g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03390-x
更新日期:2018-03-06 00:00:00
abstract::Properties of human brain tissue change across the lifespan. Here we model these changes in the living human brain by combining quantitative magnetic resonance imaging (MRI) measurements of R1 (1/T1) with diffusion MRI and tractography (N=102, ages 7-85). The amount of R1 change during development differs between whit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5932
更新日期:2014-09-17 00:00:00
abstract::Akt2 and its downstream effectors mediate insulin-stimulated GLUT4-storage vesicle (GSV) translocation and fusion with the plasma membrane (PM). Using mass spectrometry, we identify actin-capping protein Tropomodulin 3 (Tmod3) as an Akt2-interacting partner in 3T3-L1 adipocytes. We demonstrate that Tmod3 is phosphoryl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6951
更新日期:2015-01-09 00:00:00
abstract::The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat mat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4889
更新日期:2014-05-20 00:00:00
abstract::Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06271-5
更新日期:2018-10-08 00:00:00
abstract::Understanding climate change-associated tree mortality is central to linking climate change impacts and forest structure and function. However, whether temporal increases in tree mortality are attributed to climate change or stand developmental processes remains uncertain. Furthermore, interpreting the climate change-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2681
更新日期:2013-01-01 00:00:00
abstract::Conventional implementations of two-dimensional electronic spectroscopy typically spatially average over ~1010 chromophores spread over ~104 micron square area, limiting their ability to characterize spatially heterogeneous samples. Here we present a variation of two-dimensional electronic spectroscopy that is capable...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06619-x
更新日期:2018-10-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11219-4
更新日期:2019-07-10 00:00:00
abstract::Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription facto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04719-2
更新日期:2018-06-14 00:00:00
abstract::Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the abilit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12517-7
更新日期:2019-10-18 00:00:00
abstract::Chemical functionalization is one of the most powerful and widely used strategies to control the properties of nanomaterials, particularly in the field of graphene. However, the ill-defined structure of the present functionalized graphene inhibits atomically precise structural characterization and structure-correlated...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3646
更新日期:2013-01-01 00:00:00
abstract::In genome editing with CRISPR-Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR). CtIP, a key protein in early steps of homologous recombination, is fused to Cas9 and stimulates transgene integrat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03475-7
更新日期:2018-03-19 00:00:00
abstract::Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In vertebrates, SREBP activation is mainly contr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09152-7
更新日期:2019-03-22 00:00:00
abstract::There is a critical need for standard approaches to assess, report and compare the technical performance of genome-scale differential gene expression experiments. Here we assess technical performance with a proposed standard 'dashboard' of metrics derived from analysis of external spike-in RNA control ratio mixtures. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6125
更新日期:2014-09-25 00:00:00
abstract::Band-inverted electron-hole bilayers support quantum spin Hall insulator and exciton condensate phases. Interest in quantum spin Hall effect in these systems has recently put them in the spotlight. We investigate such a bilayer in an external magnetic field. We show that the interlayer correlations lead to formation o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10462
更新日期:2016-01-25 00:00:00
abstract::Electrically pumped organic lasing is one of the most challenging issues in organic optoelectronics. We present a systematic theoretical investigation to screen out electrical pumping lasing molecules over a wide range of organic materials. With the electronic structure information obtained from time-dependent density...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18144-x
更新日期:2020-09-08 00:00:00
abstract::Solitary, persistent wave packets called solitons hold potential to transfer information and energy across a wide range of spatial and temporal scales in physical, chemical, and biological systems. Mechanical solitons characteristically emerge either as a single wave packet or uncorrelated propagating topological enti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13546-y
更新日期:2019-12-06 00:00:00
abstract::Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12314-2
更新日期:2019-09-18 00:00:00
abstract::Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03552-x
更新日期:2018-03-23 00:00:00
abstract::Recently, broken symmetry effect induced edge states in two-dimensional electronic systems have attracted great attention. However, whether edge states may exist in strongly correlated oxides is not yet known. In this work, using perovskite manganites as prototype systems, we demonstrate that edge states do exist in s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7179
更新日期:2015-02-04 00:00:00
abstract::Moiré superlattices (MSLs) are modulated structures produced from homogeneous or heterogeneous 2D layers stacked with a twist angle and/or lattice mismatch. Expanding the range of available materials, methods for fabricating MSL, and realization of unique emergent properties are key challenges. Here we report a facile...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12347-7
更新日期:2019-10-02 00:00:00
abstract::Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could introduce site-specific...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13330
更新日期:2016-11-02 00:00:00
abstract::How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is unce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10811-y
更新日期:2019-06-26 00:00:00
abstract::Prompt identification of acute coronary syndrome is a challenge in clinical practice. The 12-lead electrocardiogram (ECG) is readily available during initial patient evaluation, but current rule-based interpretation approaches lack sufficient accuracy. Here we report machine learning-based methods for the prediction o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17804-2
更新日期:2020-08-07 00:00:00
abstract::In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04164-1
更新日期:2018-05-01 00:00:00
abstract::Various promising qubit concepts have been put forward recently based on engineered superconductor subgap states like Andreev bound states, Majorana zero modes or the Yu-Shiba-Rusinov (Shiba) states. The coupling of these subgap states via a superconductor strongly depends on their spatial extension and is an essentia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15322-9
更新日期:2020-04-14 00:00:00
abstract::How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of wh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11452-x
更新日期:2019-08-08 00:00:00
abstract::Bloch electrons lacking inversion symmetry exhibit orbital magnetic moments owing to the rotation around their center of mass; this moment induces a valley splitting in a magnetic field. For the graphene/h-BN moiré superlattice, inversion symmetry is broken by the h-BN. The superlattice potential generates a series of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19043-x
更新日期:2020-10-23 00:00:00