Abstract:
:Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initially observe potential T cell bystander activation in a cohort of human vaccine recipients. Using a mouse model system, we then find that memory CD8+ T cells are specifically recruited to sites with activated antigen-presenting cells (APCs) in a CXCR3-dependent manner. In addition, CXCR3 is also necessary for T cell clustering around APCs and T cell bystander activation, which temporospatially overlaps with the subsequent antigen-specific T cell response. Our data thus suggest that bystander activation is part of the initial localized immune response, and is mediated by a site-specific recruitment process of memory T cells.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Maurice NJ,McElrath MJ,Andersen-Nissen E,Frahm N,Prlic Mdoi
10.1038/s41467-019-12980-2subject
Has Abstractpub_date
2019-11-01 00:00:00pages
4987issue
1issn
2041-1723pii
10.1038/s41467-019-12980-2journal_volume
10pub_type
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