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High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model.

Abstract：

:The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat maternal or postnatal diet, but not obesity per se, structures the offspring's intestinal microbiome in Macaca fuscata (Japanese macaque). The resultant microbial dysbiosis is only partially corrected by a low-fat, control diet after weaning. Unexpectedly, early exposure to a high-fat diet diminished the abundance of non-pathogenic Campylobacter in the juvenile gut, suggesting a potential role for dietary fat in shaping commensal microbial communities in primates. Our data challenge the concept of an obesity-causing gut microbiome and rather provide evidence for a contribution of the maternal diet in establishing the microbiota, which in turn affects intestinal maintenance of metabolic health.

journal_name

Nat Commun

journal_title

Nature communications

authors

Ma J,Prince AL,Bader D,Hu M,Ganu R,Baquero K,Blundell P,Alan Harris R,Frias AE,Grove KL,Aagaard KM

doi

10.1038/ncomms4889

subject

Has Abstract

pub_date

2014-05-20 00:00:00

pages

3889

issn

2041-1723

pii

ncomms4889

journal_volume

5

pub_type

杂志文章

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