Abstract:
:Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to study disease pathophysiology, we generated Mgme1 knockout mice and report that homozygous knockouts develop depletion and multiple deletions of mtDNA. The mtDNA replication stalling phenotypes vary dramatically in different tissues of Mgme1 knockout mice. Mice with MGME1 deficiency accumulate a long linear subgenomic mtDNA species, similar to the one found in mtDNA mutator mice, but do not develop progeria. This finding resolves a long-standing debate by showing that point mutations of mtDNA are the main cause of progeria in mtDNA mutator mice. We also propose a role for MGME1 in the regulation of replication and transcription termination at the end of the control region of mtDNA.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Matic S,Jiang M,Nicholls TJ,Uhler JP,Dirksen-Schwanenland C,Polosa PL,Simard ML,Li X,Atanassov I,Rackham O,Filipovska A,Stewart JB,Falkenberg M,Larsson NG,Milenkovic Ddoi
10.1038/s41467-018-03552-xsubject
Has Abstractpub_date
2018-03-23 00:00:00pages
1202issue
1issn
2041-1723pii
10.1038/s41467-018-03552-xjournal_volume
9pub_type
杂志文章abstract::Neuroimaging evidence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and salience (SN) networks. Here we use human intracranial electroencephalography to investigate the behavioral relevance of fine-grained dynamics within and between these networks. The three n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14166-2
更新日期:2020-01-16 00:00:00
abstract::Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11460
更新日期:2016-05-10 00:00:00
abstract::As influenza A viruses remain a major threat to human health worldwide, the discovery of broadly neutralizing monoclonal antibodies that recognize conserved epitopes would facilitate the development of antibody-based therapeutic strategies. Here we report that a VH4-4-encoded human mAb named 3E1 could neutralize H1 an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13577
更新日期:2016-12-02 00:00:00
abstract::Amongst the many spectacular properties of hybrid lead halide perovskites, their defect tolerance is regarded as the key enabler for a spectrum of high-performance optoelectronic devices that propel perovskites to prominence. However, the plateauing efficiency enhancement of perovskite devices calls into question the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16463-7
更新日期:2020-06-01 00:00:00
abstract::Future energy demand is likely to increase due to climate change, but the magnitude depends on many interacting sources of uncertainty. We combine econometrically estimated responses of energy use to income, hot and cold days with future projections of spatial population and national income under five socioeconomic sc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10399-3
更新日期:2019-06-24 00:00:00
abstract::MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13964
更新日期:2017-01-03 00:00:00
abstract::The host-guest recognition between two macrocycles to form hierarchical non-intertwined ring-in-ring assemblies remains an interesting and challenging target in noncovalent synthesis. Herein, we report the design and characterization of a box-in-box assembly on the basis of host-guest radical-pairing interactions betw...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07673-1
更新日期:2018-12-10 00:00:00
abstract::The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI. We find that microglia are highly dynamic and proliferate extensively ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08446-0
更新日期:2019-01-31 00:00:00
abstract::Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2595
更新日期:2013-01-01 00:00:00
abstract::Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hy...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/ncomms5211
更新日期:2014-06-26 00:00:00
abstract::For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10474
更新日期:2016-01-25 00:00:00
abstract::The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3342
更新日期:2013-01-01 00:00:00
abstract::BKM120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer, but it interferes as an off-target effect with microtubule polymerization. Here, we developed two chemical derivatives that differ from BKM120 by only one atom. We show that these minute changes sep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14683
更新日期:2017-03-09 00:00:00
abstract::The respiratory chain in mitochondria is composed of membrane-bound proteins that couple electron transfer to proton translocation across the inner membrane. These charge-transfer reactions are regulated by the proton electrochemical gradient that is generated and maintained by the transmembrane charge transfer. Here,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05615-5
更新日期:2018-08-09 00:00:00
abstract::Microbial communities mediating anaerobic ammonium oxidation (anammox) represent one of the most energy-efficient environmental biotechnologies for nitrogen removal from wastewater. However, little is known about the functional role heterotrophic bacteria play in anammox granules. Here, we use genome-centric metagenom...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15416
更新日期:2017-05-31 00:00:00
abstract::The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alterna...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14763
更新日期:2017-03-27 00:00:00
abstract::The mechanisms underlying how cells subjected to genotoxic stress reestablish reduction-oxidation (redox) homeostasis to scavenge genotoxic stress-induced reactive oxygen species (ROS), which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we report that, via a TCF...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11696-7
更新日期:2019-08-21 00:00:00
abstract::Palaeo data suggest that Greenland must have been largely ice free during Marine Isotope Stage 11 (MIS-11). However, regional summer insolation anomalies were modest during this time compared to MIS-5e, when the Greenland ice sheet likely lost less volume. Thus it remains unclear how such conditions led to an almost c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16008
更新日期:2017-07-06 00:00:00
abstract::Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00608-2
更新日期:2017-09-19 00:00:00
abstract::Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2041
更新日期:2012-01-01 00:00:00
abstract::Emerging quantum technologies require mastering thermal management, especially at the nanoscale. It is now accepted that thermal metamaterial-based phonon manipulation is possible, especially at sub-kelvin temperatures. In these extreme limits of low temperatures and dimensions, heat conduction enters a quantum regime...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06791-0
更新日期:2018-10-16 00:00:00
abstract::The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or from pre-existing cardiomyocytes that re-enter the cell cycle. Here, we...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02891-z
更新日期:2018-02-21 00:00:00
abstract::Rechargeable magnesium batteries are one of the most promising candidates for next-generation battery technologies. Despite recent significant progress in the development of efficient electrolytes, an on-going challenge for realization of rechargeable magnesium batteries remains to overcome the sluggish kinetics cause...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07484-4
更新日期:2018-11-30 00:00:00
abstract::Primitive carbonaceous chondrites contain a large array of organic compounds dominated by insoluble organic matter (IOM). A striking feature of this IOM is the systematic enrichment in deuterium compared with the solar hydrogen reservoir. This enrichment has been taken as a sign of low-temperature ion-molecule or gas-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9567
更新日期:2015-10-13 00:00:00
abstract::Single-photon counters are single-pixel binary devices that click upon the absorption of a photon but obscure its spectral information, whereas resolving the color of detected photons has been in critical demand for frontier astronomical observation, spectroscopic imaging and wavelength division multiplexed quantum co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12149-x
更新日期:2019-09-10 00:00:00
abstract::Transmission through disordered samples can be controlled by illuminating a sample with waveforms corresponding to the eigenchannels of the transmission matrix (TM). But can the TM be exploited to selectively excite quasi-normal modes and so control the spatial profile and dwell time inside the medium? We show in micr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07180-3
更新日期:2018-11-09 00:00:00
abstract::Two-dimensional hybrid organic-inorganic perovskites with strongly bound excitons and tunable structures are desirable for optoelectronic applications. Exciton transport and annihilation are two key processes in determining device efficiencies; however, a thorough understanding of these processes is hindered by that a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14403-z
更新日期:2020-01-31 00:00:00
abstract::In the evolutionary arms race between microbes, their parasites, and their neighbours, the capacity for rapid protein diversification is a potent weapon. Diversity-generating retroelements (DGRs) use mutagenic reverse transcription and retrohoming to generate myriad variants of a target gene. Originally discovered in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7585
更新日期:2015-03-23 00:00:00
abstract::The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01389-4
更新日期:2017-11-03 00:00:00
abstract::Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform various physiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain. Despite progress in structure-function analysis, the conformational rearrangements underlying the gating of these channel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12789
更新日期:2016-09-20 00:00:00