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Control of transmembrane charge transfer in cytochrome c oxidase by the membrane potential.

Abstract：

:The respiratory chain in mitochondria is composed of membrane-bound proteins that couple electron transfer to proton translocation across the inner membrane. These charge-transfer reactions are regulated by the proton electrochemical gradient that is generated and maintained by the transmembrane charge transfer. Here, we investigate this feedback mechanism in cytochrome c oxidase in intact inner mitochondrial membranes upon generation of an electrochemical potential by hydrolysis of ATP. The data indicate that a reaction step that involves proton uptake to the catalytic site and presumably proton translocation is impaired by the potential, but electron transfer is not affected. These results define the order of electron and proton-transfer reactions and suggest that the proton pump is regulated by the transmembrane electrochemical gradient through control of internal proton transfer rather than by control of electron transfer.

journal_name

Nat Commun

journal_title

Nature communications

authors

Björck ML,Brzezinski P

doi

10.1038/s41467-018-05615-5

subject

Has Abstract

pub_date

2018-08-09 00:00:00

pages

3187

issue

1

issn

2041-1723

pii

10.1038/s41467-018-05615-5

journal_volume

9

pub_type

杂志文章

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