Abstract:
:The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC) investment. Here, we show using Myh11-CreERT2 lineage-tracing with inducible SMC and pericyte (SMC-P) knockout of Oct4 that Oct4 regulates perivascular cell migration and recruitment during angiogenesis. Knockout of Oct4 in perivascular cells significantly impairs perivascular cell migration, increases perivascular cell death, delays endothelial cell migration, and promotes vascular leakage following corneal angiogenic stimulus. Knockout of Oct4 in perivascular cells also impairs perfusion recovery and decreases angiogenesis following hindlimb ischemia. Transcriptomic analyses demonstrate that expression of the migratory gene Slit3 is reduced following loss of Oct4 in cultured SMCs, and in Oct4-deficient perivascular cells in ischemic hindlimb muscle. Together, these results provide evidence that Oct4 plays an essential role within perivascular cells in injury- and hypoxia-induced angiogenesis.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hess DL,Kelly-Goss MR,Cherepanova OA,Nguyen AT,Baylis RA,Tkachenko S,Annex BH,Peirce SM,Owens GKdoi
10.1038/s41467-019-08811-zsubject
Has Abstractpub_date
2019-02-27 00:00:00pages
967issue
1issn
2041-1723pii
10.1038/s41467-019-08811-zjournal_volume
10pub_type
杂志文章abstract::Australopithecus sediba has been hypothesized to be a close relative of the genus Homo. Here we show that MH1, the type specimen of A. sediba, was not optimized to produce high molar bite force and appears to have been limited in its ability to consume foods that were mechanically challenging to eat. Dental microwear ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10596
更新日期:2016-02-08 00:00:00
abstract::Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12646
更新日期:2016-08-26 00:00:00
abstract::The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and cancer. Multiplex genome engineering using targeted nucleases can be used to increase the efficacy and broaden the application of such therapies but carries safety risks associated with uninten...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13007-6
更新日期:2019-11-19 00:00:00
abstract::Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB via Ca2+-dependent PKC-β activation. In addition, PKC-β also phosphorylates p38 to inactivate N...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10889-4
更新日期:2019-07-02 00:00:00
abstract::Diagnosis of disease outside of sophisticated laboratories urgently requires low-cost, user-friendly devices. Disposable, instrument-free testing devices are used for home and physician office testing, but are limited in applicability to a small class of highly abundant analytes. Direct, unambiguous visual read-out is...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7978
更新日期:2015-04-22 00:00:00
abstract::Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ(18)O for Last Glacial Maximum and deglacial corals...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5102
更新日期:2014-06-17 00:00:00
abstract::In eukaryotes, telomeres cap chromosome ends to maintain genomic stability. Failure to maintain telomeres leads to their progressive erosion and eventually triggers replicative senescence, a pathway that protects against unrestricted cell proliferation. However, the mechanisms underlying the variability and dynamics o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8680
更新日期:2015-07-09 00:00:00
abstract::The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and genetically targeted approaches we have confirmed an indispensable role for vasoactive intestinal polypeptide-expressing SCN (SCNVIP) neurons, i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17197-2
更新日期:2020-09-02 00:00:00
abstract::Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with nanocarrier surfaces. Albumin is initially one of the dominant proteins ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20886-7
更新日期:2021-01-28 00:00:00
abstract::Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16546-5
更新日期:2020-06-18 00:00:00
abstract::Organolead halide perovskites have attracted substantial attention because of their excellent physical properties, which enable them to serve as the active material in emerging hybrid solid-state solar cells. Here we investigate the phototransistors based on hybrid perovskite films and provide direct evidence for thei...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9238
更新日期:2015-09-08 00:00:00
abstract::In the lead-up to the Cretaceous/Paleogene mass extinction, dinosaur diversity is argued to have been either in long-term decline, or thriving until their sudden demise. The latest Cretaceous (Campanian-Maastrichtian [83-66 Ma]) of North America provides the best record to address this debate, but even here diversity ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08997-2
更新日期:2019-03-06 00:00:00
abstract::A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14416-8
更新日期:2020-02-04 00:00:00
abstract::High-angle grain boundaries are always the preferential fatigue cracking sites, while the intrinsic fatigue cracking mechanism of coherent twin boundary remains elusive. Here we systematically investigate the fatigue cracking behaviours of copper bicrystals with a coherent twin boundary as their sole internal boundary...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4536
更新日期:2014-03-26 00:00:00
abstract::The polypterids (bichirs and ropefish) are extant basal actinopterygian (ray-finned) fishes that breathe air and share similarities with extant lobe-finned sarcopterygians (lungfishes and tetrapods) in lung structure. They are also similar to some fossil sarcopterygians, including stem tetrapods, in having large paire...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4022
更新日期:2014-01-01 00:00:00
abstract::The original version of this Article omitted the Received and Accepted dates; they should have been 22nd January 2018 and 19th April 2018, respectively. This has been corrected in the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04902-5
更新日期:2018-06-13 00:00:00
abstract::The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca2+ dissipates the H+ gradient generated by ATP hydrolysis. Afte...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12331-1
更新日期:2019-09-25 00:00:00
abstract::Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aimi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9111
更新日期:2015-09-14 00:00:00
abstract::The cycling of iron and organic matter (OM) is thought to have been a major biogeochemical cycle in the early ferruginous oceans which contributed to the deposition of banded iron formations (BIF). However, BIF are deficient in OM, which is postulated to be the result of near-complete oxidation of OM during iron reduc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12975-z
更新日期:2019-11-04 00:00:00
abstract::Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12152
更新日期:2016-08-05 00:00:00
abstract::A crumpled sheet of paper displays an intricate pattern of creases and point-like singular structures, termed d-cones. It is typically assumed that elongated creases form when ridges connecting two d-cones fold beyond the material yielding threshold, and scarring is thus a by-product of the folding dynamics that seek ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8232
更新日期:2015-06-11 00:00:00
abstract::Manipulating symmetry environments of metal ions to control functional properties is a fundamental concept of chemistry. For example, lattice strain enables control of symmetry in solids through a change in the nuclear positions surrounding a metal centre. Light-matter interactions can also induce strain but providing...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18869-9
更新日期:2020-10-14 00:00:00
abstract::Quantum point contacts exhibit mysterious conductance anomalies in addition to well-known conductance plateaus at multiples of 2e(2)/h. These 0.7 and zero-bias anomalies have been intensively studied, but their microscopic origin in terms of many-body effects is still highly debated. Here we use the charged tip of a s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5290
更新日期:2014-06-30 00:00:00
abstract::Simultaneous deep brain stimulation (DBS) and functional magnetic resonance imaging (fMRI) constitutes a powerful tool for elucidating brain functional connectivity, and exploring neuromodulatory mechanisms of DBS therapies. Previous DBS-fMRI studies could not provide full activation pattern maps due to poor MRI compa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15570-9
更新日期:2020-04-14 00:00:00
abstract::The principles governing the recruitment of interneurons during acceleration in vertebrate locomotion are unknown. In the mouse, the V2a spinal interneurons are dispensable for left-right coordination at low locomotor frequencies, but their function is essential for maintaining left-right coordination at high frequenc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1276
更新日期:2011-01-01 00:00:00
abstract::Boron has become the principle proxy for the release of seawater-derived fluids into arc volcanics, linked to cross-arc variations in boron content and isotopic ratio. Because all ocean floor serpentinites so far analysed are strongly enriched in boron, it is generally assumed that if the uppermost slab mantle is hydr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07064-6
更新日期:2018-11-02 00:00:00
abstract::Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction with scar ECM promotes pro-fibrotic features. However, the pathological intracellular mechanism in liver myofibroblasts is not completely u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12502
更新日期:2016-08-18 00:00:00
abstract::Chromatin remodeling is of crucial importance during brain development. Pathogenic alterations of several chromatin remodeling ATPases have been implicated in neurodevelopmental disorders. We describe an index case with a de novo missense mutation in CHD3, identified during whole genome sequencing of a cohort of child...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06014-6
更新日期:2018-11-05 00:00:00
abstract::The energy-level alignment of molecular transistors can be controlled by external gating to move molecular orbitals with respect to the Fermi levels of the source and drain electrodes. Two-terminal molecular tunnelling junctions, however, lack a gate electrode and suffer from Fermi-level pinning, making it difficult t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12066
更新日期:2016-07-26 00:00:00
abstract::Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03874-w
更新日期:2018-05-01 00:00:00