Abstract:
:The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and genetically targeted approaches we have confirmed an indispensable role for vasoactive intestinal polypeptide-expressing SCN (SCNVIP) neurons, including their molecular clock, in generating the mammalian locomotor activity (LMA) circadian rhythm. Optogenetic-assisted circuit mapping revealed functional, di-synaptic connectivity between SCNVIP neurons and dorsomedial hypothalamic neurons, providing a circuit substrate by which SCNVIP neurons may regulate LMA rhythms. In vivo photometry revealed that while SCNVIP neurons are acutely responsive to light, their activity is otherwise behavioral state invariant. Single-nuclei RNA-sequencing revealed that SCNVIP neurons comprise two transcriptionally distinct subtypes, including putative pacemaker and non-pacemaker populations. Altogether, our work establishes necessity of SCNVIP neurons for the LMA circadian rhythm, elucidates organization of circadian outflow from and modulatory input to SCNVIP cells, and demonstrates a subpopulation-level molecular heterogeneity that suggests distinct functions for specific SCNVIP subtypes.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Todd WD,Venner A,Anaclet C,Broadhurst RY,De Luca R,Bandaru SS,Issokson L,Hablitz LM,Cravetchi O,Arrigoni E,Campbell JN,Allen CN,Olson DP,Fuller PMdoi
10.1038/s41467-020-17197-2subject
Has Abstractpub_date
2020-09-02 00:00:00pages
4410issue
1issn
2041-1723pii
10.1038/s41467-020-17197-2journal_volume
11pub_type
杂志文章abstract::A key element enabling the microelectronic technology advances of the past decades has been the conceptualization of complex circuits with versatile functionalities as being composed of the proper combination of basic 'lumped' circuit elements (for example, inductors and capacitors). In contrast, modern nanophotonic s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4896
更新日期:2014-05-29 00:00:00
abstract::Because of the potential impact on agriculture and other key human activities, efforts have been dedicated to the local control of precipitation. The most common approach consists of dispersing small particles of dry ice, silver iodide, or other salts in the atmosphere. Here we show, using field experiments conducted ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1462
更新日期:2011-08-30 00:00:00
abstract::Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs. Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8722
更新日期:2015-07-14 00:00:00
abstract::A number of modes of oscillations of particles and fields can exist in space plasmas. Since the early 1970s, space missions have observed noise-like plasma waves near the geomagnetic equator known as 'equatorial noise'. Several theories were suggested, but clear observational evidence supported by realistic modelling ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8703
更新日期:2015-07-14 00:00:00
abstract::Expression of oestrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy, but does not guarantee patient response. The molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here we characterize the DNA methylome of endocr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8758
更新日期:2015-07-14 00:00:00
abstract::Regulation of protein N-glycosylation is essential in human cells. However, large-scale, accurate, and site-specific quantification of glycosylation is still technically challenging. We here introduce SugarQuant, an integrated mass spectrometry-based pipeline comprising protein aggregation capture (PAC)-based sample p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19052-w
更新日期:2020-10-19 00:00:00
abstract::Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin driven by processive hydrolysis of single chitin chain. Here, we analyse the mechanism underlying unidirectional movement of Serratia marcescens chitinase A (SmChiA) using high-precision single-molecule imaging, X-ray cry...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06362-3
更新日期:2018-09-19 00:00:00
abstract::Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions. Through genome-wide miRNA mim...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01954-x
更新日期:2017-11-27 00:00:00
abstract::The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNFα mRNA decay via a 3'UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify ∼ 3,800 mRNA targets with >16,000 binding sites. A large number of sites are distinct from the consensus CDE and revealed a structure-sequence ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8367
更新日期:2015-07-14 00:00:00
abstract::Energy circulation in geospace lies at the heart of space weather research. In the inner magnetosphere, the steep plasmapause boundary separates the cold dense plasmasphere, which corotates with the planet, from the hot ring current/plasma sheet outside. Theoretical studies suggested that plasmapause surface waves rel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15506-3
更新日期:2020-04-03 00:00:00
abstract::Quintulene, a non-graphitic cycloarene with fivefold symmetry, has remained synthetically elusive due to its high molecular strain originating from its curved structure. Here we report the construction of extended quintulene, which was unambiguously characterized by mass and NMR spectroscopy. The extended quintulene r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17691-7
更新日期:2020-08-07 00:00:00
abstract::Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcri...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02395-2
更新日期:2018-01-30 00:00:00
abstract::Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16813-5
更新日期:2020-06-10 00:00:00
abstract::Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02495-z
更新日期:2018-01-04 00:00:00
abstract::Although fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry and RNA-sequencing on breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopulations in metastatic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14134-w
更新日期:2020-01-21 00:00:00
abstract::Platinum nanoparticles (Pt NPs) are one of the most efficient cocatalysts in photocatalysis, and their size determines the activity and the selectivity of the catalytic reaction. Nevertheless, an in-depth understanding of the platinum's size effect in the carbon dioxide photocatalytic reduction is still lacking. Throu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03666-2
更新日期:2018-03-28 00:00:00
abstract::Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3759
更新日期:2013-01-01 00:00:00
abstract::Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2829
更新日期:2013-01-01 00:00:00
abstract::In certain artistic endeavours-such as acting in films and TV, where unemployment rates hover at around 90%-sustained productivity (simply making a living) is probably a better proxy for quantifying success than high impact. Drawing on a worldwide database, here we study the temporal profiles of activity of actors and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10213-0
更新日期:2019-06-04 00:00:00
abstract::Weyl semimetals (WSMs) are topological quantum states wherein the electronic bands disperse linearly around pairs of nodes with fixed chirality, the Weyl points. In WSMs, nonorthogonal electric and magnetic fields induce an exotic phenomenon known as the chiral anomaly, resulting in an unconventional negative longitud...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11615
更新日期:2016-05-17 00:00:00
abstract::Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell surface of immune cells and that TLR7 responses can be inhib...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7119
更新日期:2015-02-04 00:00:00
abstract::Human pressures on the ocean are thought to be increasing globally, yet we know little about their patterns of cumulative change, which pressures are most responsible for change, and which places are experiencing the greatest increases. Managers and policymakers require such information to make strategic decisions and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8615
更新日期:2015-07-14 00:00:00
abstract::Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19527-w
更新日期:2020-11-30 00:00:00
abstract::Ecosystems are composed of complex networks of many species interacting in different ways. While ecologists have long studied food webs of feeding interactions, recent studies increasingly focus on mutualistic networks including plants that exchange food for reproductive services provided by animals such as pollinator...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15688-w
更新日期:2020-05-01 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms15732. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms16183
更新日期:2018-03-12 00:00:00
abstract::All common genome-wide association (GWA) methods rely on population structure correction, to avoid false genotype-to-phenotype associations. However, population structure correction is a stringent penalization, which also impedes identification of real associations. Using recent statistical advances, we developed a ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13299
更新日期:2016-11-10 00:00:00
abstract::The future of coastal wetlands and their ecological value depend on their capacity to adapt to the interacting effects of human impacts and sea-level rise. Even though extensive wetland loss due to submergence is a possible scenario, its magnitude is highly uncertain due to limited understanding of hydrodynamic and bi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16094
更新日期:2017-07-13 00:00:00
abstract::Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3569
更新日期:2013-01-01 00:00:00
abstract::The Johnson-Kendall-Roberts theory is the basis of modern contact mechanics. It describes how two deformable objects adhere together, driven by adhesion energy and opposed by elasticity. Here we characterize the indentation of glass particles into soft, silicone substrates using confocal microscopy. We show that, wher...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3728
更新日期:2013-01-01 00:00:00
abstract::Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble proteins in lysosomes. CMA contributes to cellular quality control and is activated as part of the cellular response to different stressors. Defective CMA has been identified in ageing and different age-related diseases. Until n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1393
更新日期:2011-07-12 00:00:00