当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.

Abstract：

:The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNFα mRNA decay via a 3'UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify ∼ 3,800 mRNA targets with >16,000 binding sites. A large number of sites are distinct from the consensus CDE and revealed a structure-sequence motif with U-rich sequences embedded in hairpins. RC3H1 binds preferentially short-lived and DNA damage-induced mRNAs, indicating a role of this RNA-binding protein in the post-transcriptional regulation of the DNA damage response. Intriguingly, RC3H1 affects expression of the NF-κB pathway regulators such as IκBα and A20. RC3H1 uses ROQ and Zn-finger domains to contact a binding site in the A20 3'UTR, demonstrating a not yet recognized mode of RC3H1 binding. Knockdown of RC3H1 resulted in increased A20 protein expression, thereby interfering with IκB kinase and NF-κB activities, demonstrating that RC3H1 can modulate the activity of the IKK/NF-κB pathway.

journal_name

Nat Commun

journal_title

Nature communications

authors

Murakawa Y,Hinz M,Mothes J,Schuetz A,Uhl M,Wyler E,Yasuda T,Mastrobuoni G,Friedel CC,Dölken L,Kempa S,Schmidt-Supprian M,Blüthgen N,Backofen R,Heinemann U,Wolf J,Scheidereit C,Landthaler M

doi

10.1038/ncomms8367

subject

Has Abstract

pub_date

2015-07-14 00:00:00

pages

7367

issn

2041-1723

pii

ncomms8367

journal_volume

6

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Isolation of diborenes and their 90°-twisted diradical congeners.

    abstract：:Molecules containing multiple bonds between atoms-most often in the form of olefins-are ubiquitous in nature, commerce, and science, and as such have a huge impact on everyday life. Given their prominence, over the last few decades, frequent attempts have been made to perturb the structure and reactivity of multiply-b...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-02998-3

    authors： Böhnke J,Dellermann T,Celik MA,Krummenacher I,Dewhurst RD,Demeshko S,Ewing WC,Hammond K,Heß M,Bill E,Welz E,Röhr MIS,Mitrić R,Engels B,Meyer F,Braunschweig H

    更新日期：2018-03-22 00:00:00

  • Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers.

    abstract：:Non-pial neocortical astrocytes have historically been thought to comprise largely a nondiverse population of protoplasmic astrocytes. Here we show that astrocytes of the mouse somatosensory cortex manifest layer-specific morphological and molecular differences. Two- and three-dimensional observations revealed that as...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03940-3

    authors： Lanjakornsiripan D,Pior BJ,Kawaguchi D,Furutachi S,Tahara T,Katsuyama Y,Suzuki Y,Fukazawa Y,Gotoh Y

    更新日期：2018-04-24 00:00:00

  • Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.

    abstract：:The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain their cargo within their po...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4384

    authors： Kaittanis C,Shaffer TM,Ogirala A,Santra S,Perez JM,Chiosis G,Li Y,Josephson L,Grimm J

    更新日期：2014-03-04 00:00:00

  • Ammonia as a case study for the spontaneous ionization of a simple hydrogen-bonded compound.

    abstract：:Modern ab initio calculations predict ionic and superionic states in highly compressed water and ammonia. The prediction apparently contradicts state-of-the-art experimentally established phase diagrams overwhelmingly dominated by molecular phases. Here we present experimental evidence that the threshold pressure of ~...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4460

    authors： Palasyuk T,Troyan I,Eremets M,Drozd V,Medvedev S,Zaleski-Ejgierd P,Magos-Palasyuk E,Wang H,Bonev SA,Dudenko D,Naumov P

    更新日期：2014-03-24 00:00:00

  • Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module.

    abstract：:Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12277

    authors： Yim N,Ryu SW,Choi K,Lee KR,Lee S,Choi H,Kim J,Shaker MR,Sun W,Park JH,Kim D,Heo WD,Choi C

    更新日期：2016-07-22 00:00:00

  • The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans.

    abstract：:Six CO2 fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and meta...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18906-7

    authors： Sánchez-Andrea I,Guedes IA,Hornung B,Boeren S,Lawson CE,Sousa DZ,Bar-Even A,Claassens NJ,Stams AJM

    更新日期：2020-10-09 00:00:00

  • Impacts of irrigated agriculture on food-energy-water-CO2 nexus across metacoupled systems.

    abstract：:Irrigated agriculture has important implications for achieving the United Nations Sustainable Development Goals. However, there is a lack of systematic and quantitative analyses of its impacts on food-energy-water-CO2 nexus. Here we studied impacts of irrigated agriculture on food-energy-water-CO2 nexus across food se...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19520-3

    authors： Xu Z,Chen X,Liu J,Zhang Y,Chau S,Bhattarai N,Wang Y,Li Y,Connor T,Li Y

    更新日期：2020-11-17 00:00:00

  • Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis.

    abstract：:Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol. We present the 3.3 Å resolution single-particle cryo-electron microscopy structure of Mycobacteriu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17202-8

    authors： Tan YZ,Rodrigues J,Keener JE,Zheng RB,Brunton R,Kloss B,Giacometti SI,Rosário AL,Zhang L,Niederweis M,Clarke OB,Lowary TL,Marty MT,Archer M,Potter CS,Carragher B,Mancia F

    更新日期：2020-07-07 00:00:00

  • Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases.

    abstract：:In silico quantification of cell proportions from mixed-cell transcriptomics data (deconvolution) requires a reference expression matrix, called basis matrix. We hypothesize that matrices created using only healthy samples from a single microarray platform would introduce biological and technical biases in deconvoluti...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07242-6

    authors： Vallania F,Tam A,Lofgren S,Schaffert S,Azad TD,Bongen E,Haynes W,Alsup M,Alonso M,Davis M,Engleman E,Khatri P

    更新日期：2018-11-09 00:00:00

  • miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit.

    abstract：:Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue. Here we show that microRNA 155 is enriched in brown adipose tissue and is highly expressed in proliferating brown preadipocytes but declines after induction of ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2742

    authors： Chen Y,Siegel F,Kipschull S,Haas B,Fröhlich H,Meister G,Pfeifer A

    更新日期：2013-01-01 00:00:00

  • Ice sheets as a significant source of highly reactive nanoparticulate iron to the oceans.

    abstract：:The Greenland and Antarctic Ice Sheets cover ~ 10% of global land surface, but are rarely considered as active components of the global iron cycle. The ocean waters around both ice sheets harbour highly productive coastal ecosystems, many of which are iron limited. Measurements of iron concentrations in subglacial run...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4929

    authors： Hawkings JR,Wadham JL,Tranter M,Raiswell R,Benning LG,Statham PJ,Tedstone A,Nienow P,Lee K,Telling J

    更新日期：2014-05-21 00:00:00

  • Relativistic magnetic reconnection driven by a laser interacting with a micro-scale plasma slab.

    abstract：:Magnetic reconnection (MR) is a fundamental plasma process associated with conversion of the magnetic field energy into kinetic plasma energy, which is invoked to explain many non-thermal signatures in astrophysical events. Here we demonstrate that ultrafast relativistic MR in a magnetically dominated regime can be tr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04065-3

    authors： Yi L,Shen B,Pukhov A,Fülöp T

    更新日期：2018-04-23 00:00:00

  • Accurate, scalable and integrative haplotype estimation.

    abstract：:The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing dat...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13225-y

    authors： Delaneau O,Zagury JF,Robinson MR,Marchini JL,Dermitzakis ET

    更新日期：2019-11-28 00:00:00

  • Tuning the interactions between chiral plasmonic films and living cells.

    abstract：:Designing chiral materials to manipulate the biological activities of cells has been an important area not only in chemistry and material science, but also in cell biology and biomedicine. Here, we introduce monolayer plasmonic chiral Au nanoparticle (NP) films modified with L- or D-penicillamine (Pen) to be developed...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02268-8

    authors： Zhao X,Xu L,Sun M,Ma W,Wu X,Xu C,Kuang H

    更新日期：2017-12-08 00:00:00

  • A high-stringency blueprint of the human proteome.

    abstract：:The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...

    journal_title：Nature communications

    pub_type： 杂志文章,评审

    doi：10.1038/s41467-020-19045-9

    authors： Adhikari S,Nice EC,Deutsch EW,Lane L,Omenn GS,Pennington SR,Paik YK,Overall CM,Corrales FJ,Cristea IM,Van Eyk JE,Uhlén M,Lindskog C,Chan DW,Bairoch A,Waddington JC,Justice JL,LaBaer J,Rodriguez H,He F,Kostrzewa M

    更新日期：2020-10-16 00:00:00

  • Biological interpretation of genome-wide association studies using predicted gene functions.

    abstract：:The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enrich...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6890

    authors： Pers TH,Karjalainen JM,Chan Y,Westra HJ,Wood AR,Yang J,Lui JC,Vedantam S,Gustafsson S,Esko T,Frayling T,Speliotes EK,Genetic Investigation of ANthropometric Traits (GIANT) Consortium.,Boehnke M,Raychaudhuri S,Fehrmann RS,

    更新日期：2015-01-19 00:00:00

  • Human and mouse essentiality screens as a resource for disease gene discovery.

    abstract：:The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14284-2

    authors： Cacheiro P,Muñoz-Fuentes V,Murray SA,Dickinson ME,Bucan M,Nutter LMJ,Peterson KA,Haselimashhadi H,Flenniken AM,Morgan H,Westerberg H,Konopka T,Hsu CW,Christiansen A,Lanza DG,Beaudet AL,Heaney JD,Fuchs H,Gailus-Durner

    更新日期：2020-01-31 00:00:00

  • Biotransformation of p-xylene into terephthalic acid by engineered Escherichia coli.

    abstract：:Terephthalic acid (TPA) is an important industrial chemical currently produced by energy intensive and potentially hazardous p-xylene (pX) oxidation process. Here we report the development of metabolically engineered Escherichia coli system for biological transformation of pX into TPA. The engineered E. coli strain ha...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15689

    authors： Luo ZW,Lee SY

    更新日期：2017-05-31 00:00:00

  • Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.

    abstract：:The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are oncogenic scaffolds that nucleate the assembly of specific signalling complexes and regulate tyrosine kinase signalling. Both SgK223 and SgK269 form homo- and hetero-oligomers, a mechanism that underpins a diversity of signalling out...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01279-9

    authors： Patel O,Griffin MDW,Panjikar S,Dai W,Ma X,Chan H,Zheng C,Kropp A,Murphy JM,Daly RJ,Lucet IS

    更新日期：2017-10-27 00:00:00

  • A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.

    abstract：:Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic structure of human FALDH, t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5439

    authors： Keller MA,Zander U,Fuchs JE,Kreutz C,Watschinger K,Mueller T,Golderer G,Liedl KR,Ralser M,Kräutler B,Werner ER,Marquez JA

    更新日期：2014-07-22 00:00:00

  • MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.

    abstract：:Lung cancer is the leading cause of cancer deaths, and effective treatments are urgently needed. Loss-of-function mutations in the DNA damage response kinase ATM are common in lung adenocarcinoma but directly targeting these with drugs remains challenging. Here we report that ATM loss-of-function is synthetic lethal w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13701

    authors： Smida M,Fece de la Cruz F,Kerzendorfer C,Uras IZ,Mair B,Mazouzi A,Suchankova T,Konopka T,Katz AM,Paz K,Nagy-Bojarszky K,Muellner MK,Bago-Horvath Z,Haura EB,Loizou JI,Nijman SM

    更新日期：2016-12-06 00:00:00

  • HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from ALS patients with dif...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00911-y

    authors： Guo W,Naujock M,Fumagalli L,Vandoorne T,Baatsen P,Boon R,Ordovás L,Patel A,Welters M,Vanwelden T,Geens N,Tricot T,Benoy V,Steyaert J,Lefebvre-Omar C,Boesmans W,Jarpe M,Sterneckert J,Wegner F,Petri S,Bohl D,Vande

    更新日期：2017-10-11 00:00:00

  • Crosstalk in concurrent repeated games impedes direct reciprocity and requires stronger levels of forgiveness.

    abstract：:Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02721-8

    authors： Reiter JG,Hilbe C,Rand DG,Chatterjee K,Nowak MA

    更新日期：2018-02-07 00:00:00

  • Two spatiotemporally distinct value systems shape reward-based learning in the human brain.

    abstract：:Avoiding repeated mistakes and learning to reinforce rewarding decisions is critical for human survival and adaptive actions. Yet, the neural underpinnings of the value systems that encode different decision-outcomes remain elusive. Here coupling single-trial electroencephalography with simultaneously acquired functio...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9107

    authors： Fouragnan E,Retzler C,Mullinger K,Philiastides MG

    更新日期：2015-09-08 00:00:00

  • Atom-light interactions in photonic crystals.

    abstract：:The integration of nanophotonics and atomic physics has been a long-sought goal that would open new frontiers for optical physics, including novel quantum transport and many-body phenomena with photon-mediated atomic interactions. Reaching this goal requires surmounting diverse challenges in nanofabrication and atomic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4808

    authors： Goban A,Hung CL,Yu SP,Hood JD,Muniz JA,Lee JH,Martin MJ,McClung AC,Choi KS,Chang DE,Painter O,Kimble HJ

    更新日期：2014-05-08 00:00:00

  • Unconventional slowing down of electronic recovery in photoexcited charge-ordered La1/3Sr2/3FeO3.

    abstract：:The coupling of ordered electronic phases with lattice, spin, and orbital degrees of freedom are of central interest in strongly correlated systems. Their interplay has been intensively studied from femtosecond to picosecond time scales, while their dynamics beyond nanoseconds are usually assumed to follow lattice coo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04199-4

    authors： Zhu Y,Hoffman J,Rowland CE,Park H,Walko DA,Freeland JW,Ryan PJ,Schaller RD,Bhattacharya A,Wen H

    更新日期：2018-05-04 00:00:00

  • Local chiral symmetry breaking in triatic liquid crystals.

    abstract：:Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1803

    authors： Zhao K,Bruinsma R,Mason TG

    更新日期：2012-05-01 00:00:00

  • Spin-orbit interaction of light induced by transverse spin angular momentum engineering.

    abstract：:The investigations on optical angular momenta and their interactions have broadened our knowledge of light's behavior at sub-wavelength scales. Recent studies further unveil the extraordinary characteristics of transverse spin angular momentum in confined light fields and orbital angular momentum in optical vortices. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03237-5

    authors： Shao Z,Zhu J,Chen Y,Zhang Y,Yu S

    更新日期：2018-03-02 00:00:00

  • Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

    abstract：:Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3608

    authors： Zhang Y,Fu L,Qi X,Zhang Z,Xia Y,Jia J,Jiang J,Zhao Y,Wu G

    更新日期：2013-01-01 00:00:00

  • Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.

    abstract：:Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury, or tumor, is key to an appropriately targeted immune response. Pathogen detection is increasingly well defined mechanistically, but the discrimination of endogenous inflammatory triggers remains unclear. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01718-7

    authors： Zuliani-Alvarez L,Marzeda AM,Deligne C,Schwenzer A,McCann FE,Marsden BD,Piccinini AM,Midwood KS

    更新日期：2017-11-17 00:00:00