Abstract:
:Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-α impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-α(+) progenitor cells, as well as in human WAT-PDGFR-α(+) adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,Näslund E,Ylä-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Ydoi
10.1038/ncomms12152subject
Has Abstractpub_date
2016-08-05 00:00:00pages
12152issn
2041-1723pii
ncomms12152journal_volume
7pub_type
杂志文章abstract::The phase diagram of BaPb(1-x)Bi(x)O3 exhibits a superconducting dome in the proximity of a charge density wave phase. For the superconducting compositions, the material coexists as two structural polymorphs. Here we show, via high-resolution transmission electron microscopy, that the structural dimorphism is accommod...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9231
更新日期:2015-09-16 00:00:00
abstract::In genome editing with CRISPR-Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR). CtIP, a key protein in early steps of homologous recombination, is fused to Cas9 and stimulates transgene integrat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03475-7
更新日期:2018-03-19 00:00:00
abstract::Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05068-w
更新日期:2018-07-11 00:00:00
abstract::Cytokinetic abscission, the terminal step of cell division, crucially depends on the local constriction of ESCRT-III helices after cytoskeleton disassembly. While the microtubules of the intercellular bridge are cut by the ESCRT-associated enzyme Spastin, the mechanism that clears F-actin at the abscission site is unk...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14528
更新日期:2017-02-23 00:00:00
abstract::Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4557
更新日期:2014-04-01 00:00:00
abstract::Cyclin-dependent kinases 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry. Most human cancers contain overactive CDK4/6-cyclin D, and CDK4/6-specific inhibitors are promising anti-cancer therapeutics. Here, we investigate the critical functions of CDK4/6-cyclin D kinases, starting from an unbia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6906
更新日期:2015-01-06 00:00:00
abstract::The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a regio...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-018-06649-5
更新日期:2018-11-14 00:00:00
abstract::Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing rel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12264-9
更新日期:2019-09-19 00:00:00
abstract::'Ideal' transparent p-type semiconductors are required for the integration of high-performance thin-film transistors (TFTs) and circuits. Although CuI has recently attracted attention owing to its excellent opto-electrical properties, solution processability, and low-temperature synthesis, the uncontrolled copper vaca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18006-6
更新日期:2020-08-27 00:00:00
abstract::Among the perovskite oxide family, KTaO3 (KTO) has recently attracted considerable interest as a possible system for the realization of the Rashba effect. In this work, we report a novel conducting interface by placing KTO with another insulator, LaVO3 (LVO) and report planar Hall effect (PHE) and anisotropic magnetor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14689-z
更新日期:2020-02-13 00:00:00
abstract::The restricted availability, expense and toxicity of precious metal catalysts such as rhodium and palladium challenge the sustainability of synthetic chemistry. As such, nickel catalysts have garnered increasing attention as replacements for enyne cyclization reactions. On the other hand, bridged tricyclo[5.2.1.01,5]d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15837-1
更新日期:2020-04-20 00:00:00
abstract::Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03874-w
更新日期:2018-05-01 00:00:00
abstract::How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6367
更新日期:2014-11-06 00:00:00
abstract::Past studies of the end-Permian extinction (EPE), the largest biotic crisis of the Phanerozoic, have not resolved the timing of events in southern high-latitudes. Here we use palynology coupled with high-precision CA-ID-TIMS dating of euhedral zircons from continental sequences of the Sydney Basin, Australia, to show ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07934-z
更新日期:2019-01-23 00:00:00
abstract::Hearing is essential for the courtship of one of the major carriers of human disease, the mosquito. Males locate females through flight-tone recognition and both sexes engage in mid-air acoustic communications, which can take place within swarms containing thousands of individuals. Despite the importance of hearing fo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06388-7
更新日期:2018-09-25 00:00:00
abstract::The Hamiltonian of a closed quantum system governs its complete time evolution. While Hamiltonians with time-variation in a single basis can be recovered using a variety of methods, for more general Hamiltonians the presence of non-commuting terms complicates the reconstruction. Here using a single trapped ion, we pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11218
更新日期:2016-04-14 00:00:00
abstract::Isolators, or optical diodes, are devices enabling unidirectional light propagation by using non-reciprocal optical materials, namely materials able to break Lorentz reciprocity. The realization of isolators at terahertz frequencies is a very important open challenge made difficult by the intrinsically lossy propagati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11216
更新日期:2016-04-06 00:00:00
abstract::Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein-protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the biosynthesis of the highly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00862-4
更新日期:2017-10-19 00:00:00
abstract::Hybrid organic-inorganic perovskites have attractive optoelectronic properties including exceptional solar cell performance. The improved properties of perovskites have been attributed to polaronic effects involving stabilization of localized charge character by structural deformations and polarizations. Here we exami...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04946-7
更新日期:2018-06-28 00:00:00
abstract::Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise gene...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08054-4
更新日期:2019-01-25 00:00:00
abstract::The direct response of the tropical mixed layer to near-inertial waves (NIWs) has only rarely been observed. Here, we present upper-ocean turbulence data that provide evidence for a strongly elevated vertical diffusive heat flux across the base of the mixed layer in the presence of a NIW, thereby cooling the mixed lay...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17601-x
更新日期:2020-07-31 00:00:00
abstract::Investigating the susceptibility of oestrogen receptor-positive (ER(pos)) normal human breast epithelial cells (HBECs) for clinical purposes or basic research awaits a proficient cell-based assay. Here we set out to identify markers for isolating ER(pos) cells and to expand what appear to be post-mitotic primary cells...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9786
更新日期:2015-11-13 00:00:00
abstract::Modelling of processes involving deep Earth liquids requires information on their structures and compression mechanisms. However, knowledge of the local structures of silicates and silica (SiO2) melts at deep mantle conditions and of their densification mechanisms is still limited. Here we report the synthesis and cha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07265-z
更新日期:2018-11-15 00:00:00
abstract::Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09494-2
更新日期:2019-04-18 00:00:00
abstract::Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00108-3
更新日期:2017-07-25 00:00:00
abstract::The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interestingly, H1R and H2R ant...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4334
更新日期:2014-02-25 00:00:00
abstract::Understanding human cooperation is of major interest across the natural and social sciences. But it is unclear to what extent cooperation is actually a general concept. Most research on cooperation has implicitly assumed that a person's behaviour in one cooperative context is related to their behaviour in other settin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5939
更新日期:2014-09-16 00:00:00
abstract::G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we describe DC-34, a small molec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06315-w
更新日期:2018-10-12 00:00:00
abstract::Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its efficacy are at present largely unknown. Here we sought to elucidate t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07359-8
更新日期:2018-12-05 00:00:00
abstract::Integrating and manipulating the nano-optoelectronic properties of Van der Waals heterostructures can enable unprecedented platforms for photodetection and sensing. The main challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and efficiently convert it into an electrical sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18544-z
更新日期:2020-09-25 00:00:00