Rectified directional sensing in long-range cell migration.

abstract：:In the original version of this Article, the Acknowledgement section omitted financial support from the Deutsche Forschungsgemeinschaft grant SFB 958/A4. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Paul F,Wehmeyer C,Abualrous ET,Wu H,Crabtree MD,Schöneberg J,Clarke J,Freund C,Weikl TR,Noé F

更新日期：2018-03-09 00:00:00

abstract：:Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-de...

journal_title：Nature communications

authors： Chesi A,Wagley Y,Johnson ME,Manduchi E,Su C,Lu S,Leonard ME,Hodge KM,Pippin JA,Hankenson KD,Wells AD,Grant SFA

更新日期：2019-03-19 00:00:00

abstract：:Social dilemmas force players to balance between personal and collective gain. In many dilemmas, such as elected governments negotiating climate-change mitigation measures, the decisions are made not by individual players but by their representatives. However, the behaviour of representatives in social dilemmas has no...

journal_title：Nature communications

authors： Milinski M,Hilbe C,Semmann D,Sommerfeld R,Marotzke J

更新日期：2016-03-07 00:00:00

abstract：:The Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces telomere relocalization to nuclear pores early after telomerase inactivation. This Nup1 modification also impairs the reloc...

journal_title：Nature communications

authors： Aguilera P,Whalen J,Minguet C,Churikov D,Freudenreich C,Simon MN,Géli V

更新日期：2020-01-09 00:00:00

abstract：:Lithium- and sodium-rich layered transition-metal oxides have recently been attracting significant interest because of their large capacity achieved by additional oxygen-redox reactions. However, layered transition-metal oxides exhibit structural degradation such as cation migration, layer exfoliation or cracks upon d...

journal_title：Nature communications

authors： Mortemard de Boisse B,Reynaud M,Ma J,Kikkawa J,Nishimura SI,Casas-Cabanas M,Delmas C,Okubo M,Yamada A

更新日期：2019-05-16 00:00:00

abstract：:An essential issue in the development of materials presenting an accurately functionalized surface is to achieve control of layer structuring. Whereas the very popular method based on the spontaneous adsorption of alkanethiols on metal faces stability problems, the reductive electrografting of aryldiazonium salts yiel...

journal_title：Nature communications

authors： Mattiuzzi A,Jabin I,Mangeney C,Roux C,Reinaud O,Santos L,Bergamini JF,Hapiot P,Lagrost C

更新日期：2012-01-01 00:00:00

abstract：:The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental overexpression of TRF2 ...

journal_title：Nature communications

authors： Nera B,Huang HS,Lai T,Xu L

更新日期：2015-12-07 00:00:00

abstract：:Black phosphorus, a fast emerging two-dimensional material, has been configured as field effect transistors, showing a hole-transport-dominated ambipolar characteristic. Here we report an effective modulation on ambipolar characteristics of few-layer black phosphorus transistors through in situ surface functionalizati...

journal_title：Nature communications

authors： Xiang D,Han C,Wu J,Zhong S,Liu Y,Lin J,Zhang XA,Ping Hu W,Özyilmaz B,Neto AH,Wee AT,Chen W

更新日期：2015-03-12 00:00:00

abstract：:Although research on human-mediated exchanges of species has substantially intensified during the last centuries, we know surprisingly little about temporal dynamics of alien species accumulations across regions and taxa. Using a novel database of 45,813 first records of 16,926 established alien species, we show that ...

journal_title：Nature communications

authors： Seebens H,Blackburn TM,Dyer EE,Genovesi P,Hulme PE,Jeschke JM,Pagad S,Pyšek P,Winter M,Arianoutsou M,Bacher S,Blasius B,Brundu G,Capinha C,Celesti-Grapow L,Dawson W,Dullinger S,Fuentes N,Jäger H,Kartesz J,Kenis M

更新日期：2017-02-15 00:00:00

abstract：:Interactions between absorbers and plasmonic metasurfaces can give rise to unique optical properties not present for either of the individual materials and can influence the performance of a host of optical sensing and thin-film optoelectronic applications. Here we identify three distinct mode types of absorber-coated...

journal_title：Nature communications

authors： Petoukhoff CE,O'Carroll DM

更新日期：2015-08-14 00:00:00

abstract：:Symmetry and topology are two fundamental aspects of many quantum states of matter. Recently new topological materials, higher-order topological insulators, were discovered, featuring bulk-edge-corner correspondence that goes beyond the conventional topological paradigms. Here we discover experimentally that the nonsy...

journal_title：Nature communications

authors： Zhang X,Lin ZK,Wang HX,Xiong Z,Tian Y,Lu MH,Chen YF,Jiang JH

更新日期：2020-01-03 00:00:00

abstract：:The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E ...

journal_title：Nature communications

authors： Kawamura A,Münzel M,Kojima T,Yapp C,Bhushan B,Goto Y,Tumber A,Katoh T,King ON,Passioura T,Walport LJ,Hatch SB,Madden S,Müller S,Brennan PE,Chowdhury R,Hopkinson RJ,Suga H,Schofield CJ

更新日期：2017-04-06 00:00:00

abstract：:We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutat...

journal_title：Nature communications

authors： Walker BA,Wardell CP,Murison A,Boyle EM,Begum DB,Dahir NM,Proszek PZ,Melchor L,Pawlyn C,Kaiser MF,Johnson DC,Qiang YW,Jones JR,Cairns DA,Gregory WM,Owen RG,Cook G,Drayson MT,Jackson GH,Davies FE,Morgan GJ

更新日期：2015-04-23 00:00:00

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:One of the hallmark experiments of quantum transport is the observation of the quantized resistance in a point contact in GaAs/AlGaAs heterostructures. Being formed with split gate technology, these structures represent in an ideal manner equilibrium reservoirs which are connected only through a few electron mode chan...

journal_title：Nature communications

authors： Thierschmann H,Mulazimoglu E,Manca N,Goswami S,Klapwijk TM,Caviglia AD

更新日期：2018-06-11 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00

abstract：:Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simplest. Its greatest limitation is that the results are qualitative....

journal_title：Nature communications

authors： Luo Z,Zhao Y,Darwish T,Wang Y,Hou J,Stellacci F

更新日期：2018-10-26 00:00:00

abstract：:Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxa...

journal_title：Nature communications

authors： Rodrigues DC,Harvey EM,Suraj R,Erickson SL,Mohammad L,Ren M,Liu H,He G,Kaplan DR,Ellis J,Yang G

更新日期：2020-04-24 00:00:00

abstract：:Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understandin...

journal_title：Nature communications

authors： Zhu Z,Zhang S,Liu H,Shen H,Lin X,Yang F,Zhou YJ,Jin G,Ye M,Zou H,Zhao ZK

更新日期：2012-01-01 00:00:00

abstract：:The coastal sea levels along the Northeast Coast of North America show significant year-to-year fluctuations in a general upward trend. The analysis of long-term tide gauge records identified an extreme sea-level rise (SLR) event during 2009-10. Within this 2-year period, the coastal sea level north of New York City j...

journal_title：Nature communications

authors： Goddard PB,Yin J,Griffies SM,Zhang S

更新日期：2015-02-24 00:00:00

abstract：:Quantifying chemical compositions around nanovoids is a fundamental task for research and development of various materials. Atom probe tomography (APT) and scanning transmission electron microscopy (STEM) are currently the most suitable tools because of their ability to probe materials at the nanoscale. Both technique...

journal_title：Nature communications

authors： Wang X,Hatzoglou C,Sneed B,Fan Z,Guo W,Jin K,Chen D,Bei H,Wang Y,Weber WJ,Zhang Y,Gault B,More KL,Vurpillot F,Poplawsky JD

更新日期：2020-02-24 00:00:00

abstract：:Symbiotic associations occur in every habitat on earth, but we know very little about their evolutionary histories. Current models of trait evolution cannot adequately reconstruct the deep history of symbiotic innovation, because they assume homogenous evolutionary processes across millions of years. Here we use a rec...

journal_title：Nature communications

authors： Werner GD,Cornwell WK,Sprent JI,Kattge J,Kiers ET

更新日期：2014-06-10 00:00:00

abstract：:The original version of this Article contained errors in the units of concentration of three reagents listed in the Methods. These errors have all been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Stepanauskas R,Fergusson EA,Brown J,Poulton NJ,Tupper B,Labonté JM,Becraft ED,Brown JM,Pachiadaki MG,Povilaitis T,Thompson BP,Mascena CJ,Bellows WK,Lubys A

更新日期：2017-12-12 00:00:00

abstract：:The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution fea...

journal_title：Nature communications

authors： Libertini E,Heath SC,Hamoudi RA,Gut M,Ziller MJ,Czyz A,Ruotti V,Stunnenberg HG,Frontini M,Ouwehand WH,Meissner A,Gut IG,Beck S

更新日期：2016-06-27 00:00:00

abstract：:Elemental phosphorus is attracting growing interest across fundamental and applied fields of research. However, atomistic simulations of phosphorus have remained an outstanding challenge. Here, we show that a universally applicable force field for phosphorus can be created by machine learning (ML) from a suitably chos...

journal_title：Nature communications

authors： Deringer VL,Caro MA,Csányi G

更新日期：2020-10-29 00:00:00

abstract：:Leaves lose approximately 400 H2O molecules for every 1 CO2 gained during photosynthesis. Most long-distance water transport in plants, or xylem sap flow, serves to replace this water to prevent desiccation. Theory predicts that the largest vessels contribute disproportionately to overall sap flow because flow in pipe...

journal_title：Nature communications

authors： Bouda M,Windt CW,McElrone AJ,Brodersen CR

更新日期：2019-12-10 00:00:00

abstract：:The ability to quickly spread a liquid across a surface and form a film is fundamental for a diverse range of technological processes, including printing, painting and spraying. Here we show that liquid dielectrophoresis or electrowetting can produce wetting on normally non-wetting surfaces, without needing modificati...

journal_title：Nature communications

authors： McHale G,Brown CV,Sampara N

更新日期：2013-01-01 00:00:00

abstract：:Pulsars are rotating neutron stars emitting lighthouse-like beams. Owing to their unique properties, pulsars are a unique astrophysical tool to test general relativity, inform on matter in extreme conditions, and probe galactic magnetic fields. Understanding pulsar physics and emission mechanisms is critical to these ...

journal_title：Nature communications

authors： Gueroult R,Shi Y,Rax JM,Fisch NJ

更新日期：2019-07-19 00:00:00

abstract：:Bacteria release membrane vesicles (MVs) that play important roles in various biological processes. However, the mechanisms of MV formation in Gram-positive bacteria are unclear, as these cells possess a single cytoplasmic membrane that is surrounded by a thick cell wall. Here we use live cell imaging and electron cry...

journal_title：Nature communications

authors： Toyofuku M,Cárcamo-Oyarce G,Yamamoto T,Eisenstein F,Hsiao CC,Kurosawa M,Gademann K,Pilhofer M,Nomura N,Eberl L

更新日期：2017-09-07 00:00:00

abstract：:Pools of carbon dioxide are found in natural geological accumulations and in engineered storage in saline aquifers. It has been thought that once this CO2 dissolves in the formation water, making it denser, convection streams will transport it efficiently to depth, but this may not be so. Here, we assess theoretically...

journal_title：Nature communications

authors： Cardoso SS,Andres JT

更新日期：2014-12-11 00:00:00