Feedforward prediction error signals during episodic memory retrieval.

Abstract:

:Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for future experience within neocortical-medial temporal lobe circuits. When subsequent experiences violate these expectations, we find a 80-120 Hz prediction error signal that emerges in both visual association areas and the medial temporal lobe. Critically, this error signal emerges in visual association areas first and then propagates to the medial temporal lobe. This error signal is accompanied by alpha coherence between the two regions. Our data therefore suggest that internal models formed from episodic memories are generated throughout the visual hierarchy after just a single exposure, and that these internal models are then used for comparison with future experiences.

journal_name

Nat Commun

journal_title

Nature communications

authors

Haque RU,Inati SK,Levey AI,Zaghloul KA

doi

10.1038/s41467-020-19828-0

subject

Has Abstract

pub_date

2020-11-27 00:00:00

pages

6075

issue

1

issn

2041-1723

pii

10.1038/s41467-020-19828-0

journal_volume

11

pub_type

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