Abstract:
:Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for future experience within neocortical-medial temporal lobe circuits. When subsequent experiences violate these expectations, we find a 80-120 Hz prediction error signal that emerges in both visual association areas and the medial temporal lobe. Critically, this error signal emerges in visual association areas first and then propagates to the medial temporal lobe. This error signal is accompanied by alpha coherence between the two regions. Our data therefore suggest that internal models formed from episodic memories are generated throughout the visual hierarchy after just a single exposure, and that these internal models are then used for comparison with future experiences.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Haque RU,Inati SK,Levey AI,Zaghloul KAdoi
10.1038/s41467-020-19828-0subject
Has Abstractpub_date
2020-11-27 00:00:00pages
6075issue
1issn
2041-1723pii
10.1038/s41467-020-19828-0journal_volume
11pub_type
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