The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors.

abstract：:In nature, plant tendrils can produce two fundamental motion modes, bending and chiral twisting (helical curling) distortions, under the stimuli of sunlight, humidity, wetting or other atmospheric conditions. To date, many artificial plant-like mechanical machines have been developed. Although some previously reported...

journal_title：Nature communications

authors： Wang M,Lin BP,Yang H

更新日期：2016-12-22 00:00:00

abstract：:Enantioselective approaches to synthesize six-membered oxacycles with multiple stereogenic centres are in high demand to enable the discovery of new therapeutic agents. Here we present a concise organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans involving s...

journal_title：Nature communications

authors： Yoneda N,Fujii Y,Matsumoto A,Asano K,Matsubara S

更新日期：2017-11-09 00:00:00

abstract：:HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investi...

journal_title：Nature communications

authors： Huang KH,Bonsall D,Katzourakis A,Thomson EC,Fidler SJ,Main J,Muir D,Weber JN,Frater AJ,Phillips RE,Pybus OG,Goulder PJ,McClure MO,Cooke GS,Klenerman P

更新日期：2010-10-19 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Kuijk E,Jager M,van der Roest B,Locati MD,Van Hoeck A,Korzelius J,Janssen R,Besselink N,Boymans S,van Boxtel R,Cuppen E

更新日期：2020-08-04 00:00:00

abstract：:Incorporating oxophilic metals into noble metal-based catalysts represents an emerging strategy to improve the catalytic performance of electrocatalysts in fuel cells. However, effects of the distance between the noble metal and oxophilic metal active sites on the catalytic performance have rarely been investigated. H...

journal_title：Nature communications

authors： Chen L,Lu L,Zhu H,Chen Y,Huang Y,Li Y,Wang L

更新日期：2017-01-10 00:00:00

abstract：:The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major component...

journal_title：Nature communications

authors： Haller F,Bieg M,Will R,Körner C,Weichenhan D,Bott A,Ishaque N,Lutsik P,Moskalev EA,Mueller SK,Bähr M,Woerner A,Kaiser B,Scherl C,Haderlein M,Kleinheinz K,Fietkau R,Iro H,Eils R,Hartmann A,Plass C,Wiemann S,Aga

更新日期：2019-01-21 00:00:00

abstract：:Engineering strong metal-support interactions (SMSI) is an effective strategy for tuning structures and performances of supported metal catalysts but induces poor exposure of active sites. Here, we demonstrate a strong metal-support interaction via a reverse route (SMSIR) by starting from the final morphology of SMSI ...

journal_title：Nature communications

authors： Wu P,Tan S,Moon J,Yan Z,Fung V,Li N,Yang SZ,Cheng Y,Abney CW,Wu Z,Savara A,Momen AM,Jiang DE,Su D,Li H,Zhu W,Dai S,Zhu H

更新日期：2020-06-16 00:00:00

abstract：:Epithelial barrier function is maintained by coordination of cell proliferation and cell loss, whereas barrier dysfunction can lead to disease and organismal death. JNK signalling is a conserved stress signalling pathway activated by bacterial infection and tissue damage, often leading to apoptotic cell death and comp...

journal_title：Nature communications

authors： Zhou J,Edgar BA,Boutros M

更新日期：2017-03-08 00:00:00

abstract：:Two voltage-gated calcium channel subtypes-CaV1.2 and CaV1.3-underlie the major L-type Ca(2+) currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties, and at high doses classic calcium channel blockers, such as dihydropy...

journal_title：Nature communications

authors： Huang H,Ng CY,Yu D,Zhai J,Lam Y,Soong TW

更新日期：2014-07-24 00:00:00

abstract：:The photon-like behavior of electrons in graphene causes unusual confinement properties that depend strongly on the geometry and strength of the surrounding potential. We report bottom-up synthesis of atomically-precise one-dimensional (1D) arrays of point charges on graphene that allow exploration of a new type of su...

journal_title：Nature communications

authors： Lu J,Tsai HZ,Tatan AN,Wickenburg S,Omrani AA,Wong D,Riss A,Piatti E,Watanabe K,Taniguchi T,Zettl A,Pereira VM,Crommie MF

更新日期：2019-01-29 00:00:00

abstract：:Understanding the impact of rare variants is essential to understanding human health. We analyze rare (MAF < 0.1%) variants against 4264 phenotypes in 49,960 exome-sequenced individuals from the UK Biobank and 1934 phenotypes (1821 overlapping with UK Biobank) in 21,866 members of the Healthy Nevada Project (HNP) coho...

journal_title：Nature communications

authors： Cirulli ET,White S,Read RW,Elhanan G,Metcalf WJ,Tanudjaja F,Fath DM,Sandoval E,Isaksson M,Schlauch KA,Grzymski JJ,Lu JT,Washington NL

更新日期：2020-01-28 00:00:00

abstract：:In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel comp...

journal_title：Nature communications

authors： Sekitani T,Yokota T,Kuribara K,Kaltenbrunner M,Fukushima T,Inoue Y,Sekino M,Isoyama T,Abe Y,Onodera H,Someya T

更新日期：2016-04-29 00:00:00

abstract：:Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstruction of Ebp1 boun...

journal_title：Nature communications

authors： Wild K,Aleksić M,Lapouge K,Juaire KD,Flemming D,Pfeffer S,Sinning I

更新日期：2020-02-07 00:00:00

abstract：:In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch--two central cell fate events--take place in the G1 phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G1/S transition, whose major regulatory feature is multisite ...

journal_title：Nature communications

authors： Palumbo P,Vanoni M,Cusimano V,Busti S,Marano F,Manes C,Alberghina L

更新日期：2016-04-20 00:00:00

abstract：:The insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) are highly related receptor tyrosine kinases with a disulfide-linked homodimeric architecture. Ligand binding to the receptor ectodomain triggers tyrosine autophosphorylation of the cytoplasmic domains, which stimulates catalytic activity and ...

journal_title：Nature communications

authors： Cabail MZ,Li S,Lemmon E,Bowen ME,Hubbard SR,Miller WT

更新日期：2015-03-11 00:00:00

abstract：:The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI. We find that microglia are highly dynamic and proliferate extensively ...

journal_title：Nature communications

authors： Bellver-Landete V,Bretheau F,Mailhot B,Vallières N,Lessard M,Janelle ME,Vernoux N,Tremblay MÈ,Fuehrmann T,Shoichet MS,Lacroix S

更新日期：2019-01-31 00:00:00

abstract：:The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data. We identify a total of 201 transc...

journal_title：Nature communications

authors： Whisnant AW,Jürges CS,Hennig T,Wyler E,Prusty B,Rutkowski AJ,L'hernault A,Djakovic L,Göbel M,Döring K,Menegatti J,Antrobus R,Matheson NJ,Künzig FWH,Mastrobuoni G,Bielow C,Kempa S,Liang C,Dandekar T,Zimmer R,Landth

更新日期：2020-04-27 00:00:00

abstract：:Cholinergic neurons in the basal forebrain project heavily to the main olfactory bulb, the first processing station in the olfactory pathway. The projections innervate multiple layers of the main olfactory bulb and strongly influence odor discrimination, detection, and learning. The precise underlying circuitry of thi...

journal_title：Nature communications

authors： Case DT,Burton SD,Gedeon JY,Williams SG,Urban NN,Seal RP

更新日期：2017-09-21 00:00:00

abstract：:Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...

journal_title：Nature communications

authors： Zakhary MJ,Gibaud T,Kaplan CN,Barry E,Oldenbourg R,Meyer RB,Dogic Z

更新日期：2014-01-01 00:00:00

abstract：:The spatial scaling of stability is key to understanding ecological sustainability across scales and the sensitivity of ecosystems to habitat destruction. Here we propose the invariability-area relationship (IAR) as a novel approach to investigate the spatial scaling of stability. The shape and slope of IAR are largel...

journal_title：Nature communications

authors： Wang S,Loreau M,Arnoldi JF,Fang J,Rahman KA,Tao S,de Mazancourt C

更新日期：2017-05-19 00:00:00

abstract：:Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural history of antibiotics and resistance. In a previous study, we discovered that multi-drug resistance is common in bacteria isolated from Lechuguilla Cave, an un...

journal_title：Nature communications

authors： Pawlowski AC,Wang W,Koteva K,Barton HA,McArthur AG,Wright GD

更新日期：2016-12-08 00:00:00

abstract：:The fracture toughness of glassy materials remains poorly understood. In large part, this is due to the disordered, intrinsically non-equilibrium nature of the glass structure, which challenges its theoretical description and experimental determination. We show that the notch fracture toughness of metallic glasses exh...

journal_title：Nature communications

authors： Ketkaew J,Chen W,Wang H,Datye A,Fan M,Pereira G,Schwarz UD,Liu Z,Yamada R,Dmowski W,Shattuck MD,O'Hern CS,Egami T,Bouchbinder E,Schroers J

更新日期：2018-08-16 00:00:00

abstract：:Haploinsufficiency of the SLC2A1 gene and paucity of its translated product, the glucose transporter-1 (Glut1) protein, disrupt brain function and cause the neurodevelopmental disorder, Glut1 deficiency syndrome (Glut1 DS). There is little to suggest how reduced Glut1 causes cognitive dysfunction and no optimal treatm...

journal_title：Nature communications

authors： Tang M,Gao G,Rueda CB,Yu H,Thibodeaux DN,Awano T,Engelstad KM,Sanchez-Quintero MJ,Yang H,Li F,Li H,Su Q,Shetler KE,Jones L,Seo R,McConathy J,Hillman EM,Noebels JL,De Vivo DC,Monani UR

更新日期：2017-01-20 00:00:00

abstract：:The Hamiltonian of a closed quantum system governs its complete time evolution. While Hamiltonians with time-variation in a single basis can be recovered using a variety of methods, for more general Hamiltonians the presence of non-commuting terms complicates the reconstruction. Here using a single trapped ion, we pro...

journal_title：Nature communications

authors： de Clercq LE,Oswald R,Flühmann C,Keitch B,Kienzler D,Lo HY,Marinelli M,Nadlinger D,Negnevitsky V,Home JP

更新日期：2016-04-14 00:00:00

abstract：:Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system is de...

journal_title：Nature communications

authors： Lin H,Tan J,Zhu J,Lin S,Zhao Y,Yu W,Hojaiji H,Wang B,Yang S,Cheng X,Wang Z,Tang E,Yeung C,Emaminejad S

更新日期：2020-09-02 00:00:00

abstract：:Adaptive optics by direct imaging of the wavefront distortions of a laser-induced guide star has long been used in astronomy, and more recently in microscopy to compensate for aberrations in transparent specimens. Here we extend this approach to tissues that strongly scatter visible light by exploiting the reduced sca...

journal_title：Nature communications

authors： Wang K,Sun W,Richie CT,Harvey BK,Betzig E,Ji N

更新日期：2015-06-15 00:00:00

abstract：:In just 20 years of history, the field of optomechanics has achieved impressive progress, stepping into the quantum regime just 5 years ago. Such remarkable advance relies on the technological revolution of nano-optomechanical systems, whose sensitivity towards thermal decoherence is strongly limited due to their ultr...

journal_title：Nature communications

authors： Tavernarakis A,Stavrinadis A,Nowak A,Tsioutsios I,Bachtold A,Verlot P

更新日期：2018-02-14 00:00:00

abstract：:Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a...

journal_title：Nature communications

authors： Dadaev T,Saunders EJ,Newcombe PJ,Anokian E,Leongamornlert DA,Brook MN,Cieza-Borrella C,Mijuskovic M,Wakerell S,Olama AAA,Schumacher FR,Berndt SI,Benlloch S,Ahmed M,Goh C,Sheng X,Zhang Z,Muir K,Govindasami K,Lophatan

更新日期：2018-06-11 00:00:00

abstract：:It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct ske...

journal_title：Nature communications

authors： Li M,Wu H,Luo Z,Xia Y,Guan J,Wang T,Gu Y,Chen L,Zhang K,Ma J,Liu Y,Zhong Z,Nie J,Zhou S,Mu Z,Wang X,Qu J,Jing L,Wang H,Huang S,Yi N,Wang Z,Xi D,Wang J,Yin G,Wang L,Li N,Jiang Z,Lang Q,Xiao H,Ji

更新日期：2012-05-22 00:00:00

abstract：:Land-atmosphere exchanges influence atmospheric CO2. Emphasis has been on describing photosynthetic CO2 uptake, but less on respiration losses. New global datasets describe upper canopy dark respiration (R d) and temperature dependencies. This allows characterisation of baseline R d, instantaneous temperature response...

journal_title：Nature communications

authors： Huntingford C,Atkin OK,Martinez-de la Torre A,Mercado LM,Heskel MA,Harper AB,Bloomfield KJ,O'Sullivan OS,Reich PB,Wythers KR,Butler EE,Chen M,Griffin KL,Meir P,Tjoelker MG,Turnbull MH,Sitch S,Wiltshire A,Malhi Y

更新日期：2017-11-17 00:00:00