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Targeted diversity generation by intraterrestrial archaea and archaeal viruses.

Abstract：

:In the evolutionary arms race between microbes, their parasites, and their neighbours, the capacity for rapid protein diversification is a potent weapon. Diversity-generating retroelements (DGRs) use mutagenic reverse transcription and retrohoming to generate myriad variants of a target gene. Originally discovered in pathogens, these retroelements have been identified in bacteria and their viruses, but never in archaea. Here we report the discovery of intact DGRs in two distinct intraterrestrial archaeal systems: a novel virus that appears to infect archaea in the marine subsurface, and, separately, two uncultivated nanoarchaea from the terrestrial subsurface. The viral DGR system targets putative tail fibre ligand-binding domains, potentially generating >10(18) protein variants. The two single-cell nanoarchaeal genomes each possess ≥4 distinct DGRs. Against an expected background of low genome-wide mutation rates, these results demonstrate a previously unsuspected potential for rapid, targeted sequence diversification in intraterrestrial archaea and their viruses.

journal_name

Nat Commun

journal_title

Nature communications

authors

Paul BG,Bagby SC,Czornyj E,Arambula D,Handa S,Sczyrba A,Ghosh P,Miller JF,Valentine DL

doi

10.1038/ncomms7585

subject

Has Abstract

pub_date

2015-03-23 00:00:00

pages

6585

issn

2041-1723

pii

ncomms7585

journal_volume

6

pub_type

杂志文章

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