当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia.

A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia.

Abstract：

:Hypoxia occurs when limited oxygen supply impairs physiological functions and is a pathological hallmark of many diseases including cancer and ischemia. Thus, detection of hypoxia can guide treatment planning and serve as a predictor of patient prognosis. Unfortunately, current methods suffer from invasiveness, poor resolution and low specificity. To address these limitations, we present Hypoxia Probe 1 (HyP-1), a hypoxia-responsive agent for photoacoustic imaging. This emerging modality converts safe, non-ionizing light to ultrasound waves, enabling acquisition of high-resolution 3D images in deep tissue. HyP-1 features an N-oxide trigger that is reduced in the absence of oxygen by heme proteins such as CYP450 enzymes. Reduction of HyP-1 produces a spectrally distinct product, facilitating identification via photoacoustic imaging. HyP-1 exhibits selectivity for hypoxic activation in vitro, in living cells, and in multiple disease models in vivo. HyP-1 is also compatible with NIR fluorescence imaging, establishing its versatility as a multimodal imaging agent.

journal_name

Nat Commun

journal_title

Nature communications

authors

Knox HJ,Hedhli J,Kim TW,Khalili K,Dobrucki LW,Chan J

doi

10.1038/s41467-017-01951-0

subject

Has Abstract

pub_date

2017-11-27 00:00:00

pages

1794

issue

1

issn

2041-1723

pii

10.1038/s41467-017-01951-0

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Genetic mapping and evolutionary analysis of human-expanded cognitive networks.

    abstract：:Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical expansion of cognitive networks in the human brain, and most pronounced the DMN, runs parallel with high expre...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12764-8

    authors： Wei Y,de Lange SC,Scholtens LH,Watanabe K,Ardesch DJ,Jansen PR,Savage JE,Li L,Preuss TM,Rilling JK,Posthuma D,van den Heuvel MP

    更新日期：2019-10-24 00:00:00

  • High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy.

    abstract：:Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole's distal appendages. In this study, we use correlative super resolution and electron microscopy to precisely determine where distal appendage proteins localize in relation to the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08216-4

    authors： Bowler M,Kong D,Sun S,Nanjundappa R,Evans L,Farmer V,Holland A,Mahjoub MR,Sui H,Loncarek J

    更新日期：2019-03-01 00:00:00

  • The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.

    abstract：:Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. Here we use gene expression profiles to infer CNAs in 3,108 samples from 45 mouse models, provid...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12160

    authors： Ben-David U,Ha G,Khadka P,Jin X,Wong B,Franke L,Golub TR

    更新日期：2016-07-04 00:00:00

  • Dense GeV electron-positron pairs generated by lasers in near-critical-density plasmas.

    abstract：:Pair production can be triggered by high-intensity lasers via the Breit-Wheeler process. However, the straightforward laser-laser colliding for copious numbers of pair creation requires light intensities several orders of magnitude higher than possible with the ongoing laser facilities. Despite the numerous proposed a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13686

    authors： Zhu XL,Yu TP,Sheng ZM,Yin Y,Turcu IC,Pukhov A

    更新日期：2016-12-14 00:00:00

  • Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL.

    abstract：:Cancer evolution is fueled by epigenetic as well as genetic diversity. In chronic lymphocytic leukemia (CLL), intra-tumoral DNA methylation (DNAme) heterogeneity empowers evolution. Here, to comprehensively study the epigenetic dimension of cancer evolution, we integrate DNAme analysis with histone modification mappin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09645-5

    authors： Pastore A,Gaiti F,Lu SX,Brand RM,Kulm S,Chaligne R,Gu H,Huang KY,Stamenova EK,Béguelin W,Jiang Y,Schulman RC,Kim KT,Alonso A,Allan JN,Furman RR,Gnirke A,Wu CJ,Melnick AM,Meissner A,Bernstein BE,Abdel-Wahab O,L

    更新日期：2019-04-23 00:00:00

  • Sub-microWatt threshold nanoisland lasers.

    abstract：:Ultralow threshold nanolasers have been sought after as power efficient light sources in photonic integrated circuits. Here a single-cell nanobeam laser with a nanoisland quantum well is proposed and demonstrated. Continuous operation at 1.5 μm is achieved at room temperature with an ultralow lasing threshold of 210 n...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9276

    authors： Jang H,Karnadi I,Pramudita P,Song JH,Kim KS,Lee YH

    更新日期：2015-09-22 00:00:00

  • WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.

    abstract：:Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these cellular decisions is achieved remains elusive. The Wilms' tumour suppressor Wt1 is required for progenitor survival, but the molecular cause for renal agenesis in mu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5444

    authors： Motamedi FJ,Badro DA,Clarkson M,Lecca MR,Bradford ST,Buske FA,Saar K,Hübner N,Brändli AW,Schedl A

    更新日期：2014-07-17 00:00:00

  • Herbivorous turtle ants obtain essential nutrients from a conserved nitrogen-recycling gut microbiome.

    abstract：:Nitrogen acquisition is a major challenge for herbivorous animals, and the repeated origins of herbivory across the ants have raised expectations that nutritional symbionts have shaped their diversification. Direct evidence for N provisioning by internally housed symbionts is rare in animals; among the ants, it has be...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03357-y

    authors： Hu Y,Sanders JG,Łukasik P,D'Amelio CL,Millar JS,Vann DR,Lan Y,Newton JA,Schotanus M,Kronauer DJC,Pierce NE,Moreau CS,Wertz JT,Engel P,Russell JA

    更新日期：2018-03-06 00:00:00

  • Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

    abstract：:Laryngeal squamous cell carcinoma is a frequent and significant cause of morbidity and mortality. Here we explore the biological basis of this aggressive tumour, and identify two cell-cell adhesion genes as recurrently mutated in this malignancy. We first perform exome sequencing of four laryngeal carcinomas and their...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3531

    authors： Fanjul-Fernández M,Quesada V,Cabanillas R,Cadiñanos J,Fontanil T,Obaya A,Ramsay AJ,Llorente JL,Astudillo A,Cal S,López-Otín C

    更新日期：2013-01-01 00:00:00

  • Electronic heat flow and thermal shot noise in quantum circuits.

    abstract：:When assembling individual quantum components into a mesoscopic circuit, the interplay between Coulomb interaction and charge granularity breaks down the classical laws of electrical impedance composition. Here we explore experimentally the thermal consequences, and observe an additional quantum mechanism of electroni...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13566-8

    authors： Sivre E,Duprez H,Anthore A,Aassime A,Parmentier FD,Cavanna A,Ouerghi A,Gennser U,Pierre F

    更新日期：2019-12-10 00:00:00

  • High density mechanical energy storage with carbon nanothread bundle.

    abstract：:The excellent mechanical properties of carbon nanofibers bring promise for energy-related applications. Through in silico studies and continuum elasticity theory, here we show that the ultra-thin carbon nanothreads-based bundles exhibit a high mechanical energy storage density. Specifically, the gravimetric energy den...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15807-7

    authors： Zhan H,Zhang G,Bell JM,Tan VBC,Gu Y

    更新日期：2020-04-20 00:00:00

  • An olfactory virtual reality system for mice.

    abstract：:All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behaviora...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03262-4

    authors： Radvansky BA,Dombeck DA

    更新日期：2018-02-26 00:00:00

  • Efficient electrical control of thin-film black phosphorus bandgap.

    abstract：:Recently rediscovered black phosphorus is a layered semiconductor with promising electronic and photonic properties. Dynamic control of its bandgap can allow for the exploration of new physical phenomena. However, theoretical investigations and photoemission spectroscopy experiments indicate that in its few-layer form...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14474

    authors： Deng B,Tran V,Xie Y,Jiang H,Li C,Guo Q,Wang X,Tian H,Koester SJ,Wang H,Cha JJ,Xia Q,Yang L,Xia F

    更新日期：2017-04-19 00:00:00

  • Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.

    abstract：:γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell recepto...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14760

    authors： Davey MS,Willcox CR,Joyce SP,Ladell K,Kasatskaya SA,McLaren JE,Hunter S,Salim M,Mohammed F,Price DA,Chudakov DM,Willcox BE

    更新日期：2017-03-01 00:00:00

  • ATM specifically mediates repair of double-strand breaks with blocked DNA ends.

    abstract：:Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detai...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4347

    authors： Álvarez-Quilón A,Serrano-Benítez A,Lieberman JA,Quintero C,Sánchez-Gutiérrez D,Escudero LM,Cortés-Ledesma F

    更新日期：2014-02-27 00:00:00

  • Genomic adaptations of the halophilic Dead Sea filamentous fungus Eurotium rubrum.

    abstract：:The Dead Sea is one of the most hypersaline habitats on Earth. The fungus Eurotium rubrum (Eurotiomycetes) is among the few species able to survive there. Here we highlight its adaptive strategies, based on genome analysis and transcriptome profiling. The 26.2 Mb genome of E. rubrum shows, for example, gains in gene f...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4745

    authors： Kis-Papo T,Weig AR,Riley R,Peršoh D,Salamov A,Sun H,Lipzen A,Wasser SP,Rambold G,Grigoriev IV,Nevo E

    更新日期：2014-05-09 00:00:00

  • Design of highly efficient deep-blue organic afterglow through guest sensitization and matrices rigidification.

    abstract：:Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecule...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18572-9

    authors： Xu S,Wang W,Li H,Zhang J,Chen R,Wang S,Zheng C,Xing G,Song C,Huang W

    更新日期：2020-09-23 00:00:00

  • DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression.

    abstract：:DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progress...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8821

    authors： Cho MH,Park JH,Choi HJ,Park MK,Won HY,Park YJ,Lee CH,Oh SH,Song YS,Kim HS,Oh YH,Lee JY,Kong G

    更新日期：2015-07-22 00:00:00

  • Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.

    abstract：:Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and a...

    journal_title：Nature communications

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41467-017-01973-8

    authors： Duvallet C,Gibbons SM,Gurry T,Irizarry RA,Alm EJ

    更新日期：2017-12-05 00:00:00

  • Rational strategy for shaped nanomaterial synthesis in reverse micelle reactors.

    abstract：:The shape-controlled synthesis of nanoparticles was established in single-phase solutions by controlling growth directions of crystalline facets on seed nanocrystals kinetically; however, it was difficult to rationally predict and design nanoparticle shapes. Here we introduce a methodology to fabricate nanoparticles i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4870

    authors： Wei Z,Matsui H

    更新日期：2014-05-14 00:00:00

  • High performance tandem organic solar cells via a strongly infrared-absorbing narrow bandgap acceptor.

    abstract：:Tandem organic solar cells are based on the device structure monolithically connecting two solar cells to broaden overall absorption spectrum and utilize the photon energy more efficiently. Herein, we demonstrate a simple strategy of inserting a double bond between the central core and end groups of the small molecule...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20431-6

    authors： Jia Z,Qin S,Meng L,Ma Q,Angunawela I,Zhang J,Li X,He Y,Lai W,Li N,Ade H,Brabec CJ,Li Y

    更新日期：2021-01-08 00:00:00

  • Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome.

    abstract：:Synthetic biology tools, such as modular parts and combinatorial DNA assembly, are routinely used to optimise the productivity of heterologous metabolic pathways for biosynthesis or substrate utilisation, yet it is well established that host strain background is just as important for determining productivity. Here we ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03143-w

    authors： Blount BA,Gowers GF,Ho JCH,Ledesma-Amaro R,Jovicevic D,McKiernan RM,Xie ZX,Li BZ,Yuan YJ,Ellis T

    更新日期：2018-05-22 00:00:00

  • Increasing occurrence of cold and warm extremes during the recent global warming slowdown.

    abstract：:The recent levelling of global mean temperatures after the late 1990s, the so-called global warming hiatus or slowdown, ignited a surge of scientific interest into natural global mean surface temperature variability, observed temperature biases, and climate communication, but many questions remain about how these find...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04040-y

    authors： Johnson NC,Xie SP,Kosaka Y,Li X

    更新日期：2018-04-30 00:00:00

  • Binary tree-inspired digital dendrimer.

    abstract：:Digital polymers with precisely ordered units acting as the coded 0- or 1-bit, are introduced as a promising option for molecular data storage. However, the pursuit of better performance in terms of high storage capacity and useful functions never stops. Herein, we propose a concept of an information-coded 2D digital ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09957-6

    authors： Huang Z,Shi Q,Guo J,Meng F,Zhang Y,Lu Y,Qian Z,Li X,Zhou N,Zhang Z,Zhu X

    更新日期：2019-04-23 00:00:00

  • Proteogenomic landscape of squamous cell lung cancer.

    abstract：:How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of wh...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11452-x

    authors： Stewart PA,Welsh EA,Slebos RJC,Fang B,Izumi V,Chambers M,Zhang G,Cen L,Pettersson F,Zhang Y,Chen Z,Cheng CH,Thapa R,Thompson Z,Fellows KM,Francis JM,Saller JJ,Mesa T,Zhang C,Yoder S,DeNicola GM,Beg AA,Boyle TA

    更新日期：2019-08-08 00:00:00

  • A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation.

    abstract：:Antiretroviral therapy (ART) suppresses viral replication in people living with HIV. Yet, infected cells persist for decades on ART and viremia returns if ART is stopped. Persistence has been attributed to viral replication in an ART sanctuary and long-lived and/or proliferating latently infected cells. Using ecologic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06843-5

    authors： Reeves DB,Duke ER,Wagner TA,Palmer SE,Spivak AM,Schiffer JT

    更新日期：2018-11-16 00:00:00

  • Exploiting the speckle-correlation scattering matrix for a compact reference-free holographic image sensor.

    abstract：:The word 'holography' means a drawing that contains all of the information for light-both amplitude and wavefront. However, because of the insufficient bandwidth of current electronics, the direct measurement of the wavefront of light has not yet been achieved. Though reference-field-assisted interferometric methods h...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13359

    authors： Lee K,Park Y

    更新日期：2016-10-31 00:00:00

  • Author Correction: Molecular vibrations reduce the maximum achievable photovoltage in organic solar cells.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-15790-z

    authors： Panhans M,Hutsch S,Benduhn J,Schellhammer KS,Nikolis VC,Vangerven T,Vandewal K,Ortmann F

    更新日期：2020-04-22 00:00:00

  • Post-drought decline of the Amazon carbon sink.

    abstract：:Amazon forests have experienced frequent and severe droughts in the past two decades. However, little is known about the large-scale legacy of droughts on carbon stocks and dynamics of forests. Using systematic sampling of forest structure measured by LiDAR waveforms from 2003 to 2008, here we show a significant loss ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05668-6

    authors： Yang Y,Saatchi SS,Xu L,Yu Y,Choi S,Phillips N,Kennedy R,Keller M,Knyazikhin Y,Myneni RB

    更新日期：2018-08-09 00:00:00

  • CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

    abstract：:Chromatin remodeling is of crucial importance during brain development. Pathogenic alterations of several chromatin remodeling ATPases have been implicated in neurodevelopmental disorders. We describe an index case with a de novo missense mutation in CHD3, identified during whole genome sequencing of a cohort of child...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06014-6

    authors： Snijders Blok L,Rousseau J,Twist J,Ehresmann S,Takaku M,Venselaar H,Rodan LH,Nowak CB,Douglas J,Swoboda KJ,Steeves MA,Sahai I,Stumpel CTRM,Stegmann APA,Wheeler P,Willing M,Fiala E,Kochhar A,Gibson WT,Cohen ASA,Agb

    更新日期：2018-11-05 00:00:00