Genomic adaptations of the halophilic Dead Sea filamentous fungus Eurotium rubrum.

abstract：:Emerging evidence supports roles of enhancer RNAs (eRNAs) in regulating target gene. Here, we study eRNA regulation and function during skeletal myoblast differentiation. We provide a panoramic view of enhancer transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA pr...

journal_title：Nature communications

authors： Zhao Y,Zhou J,He L,Li Y,Yuan J,Sun K,Chen X,Bao X,Esteban MA,Sun H,Wang H

更新日期：2019-12-19 00:00:00

abstract：:The mammalian neocortex is subdivided into cytoarchitectural areas with distinct connectivity, gene expression and neural functions. Areal identity is initially specified by rostrocaudal and mediolateral gene expression gradients in neuroepithelial and radial glial progenitors (the 'protomap'). On further differentiat...

journal_title：Nature communications

authors： Alfano C,Magrinelli E,Harb K,Hevner RF,Studer M

更新日期：2014-12-05 00:00:00

abstract：:Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDE...

journal_title：Nature communications

authors： Deng Z,Mu J,Tseng M,Wattenberg B,Zhuang X,Egilmez NK,Wang Q,Zhang L,Norris J,Guo H,Yan J,Haribabu B,Miller D,Zhang HG

更新日期：2015-04-24 00:00:00

abstract：:Comparisons of climate model hindcasts with independent proxy data are essential for assessing model performance in non-analogue situations. However, standardized palaeoclimate data sets for assessing the spatial pattern of past climatic change across continents are lacking for some of the most dynamic episodes of Ear...

journal_title：Nature communications

authors： Heiri O,Brooks SJ,Renssen H,Bedford A,Hazekamp M,Ilyashuk B,Jeffers ES,Lang B,Kirilova E,Kuiper S,Millet L,Samartin S,Toth M,Verbruggen F,Watson JE,van Asch N,Lammertsma E,Amon L,Birks HH,Birks HJ,Mortensen MF,H

更新日期：2014-09-11 00:00:00

abstract：:Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidate mechanisms of adaptive resistance, we analyse the tumour immune mic...

journal_title：Nature communications

authors： Koyama S,Akbay EA,Li YY,Herter-Sprie GS,Buczkowski KA,Richards WG,Gandhi L,Redig AJ,Rodig SJ,Asahina H,Jones RE,Kulkarni MM,Kuraguchi M,Palakurthi S,Fecci PE,Johnson BE,Janne PA,Engelman JA,Gangadharan SP,Costa DB,

更新日期：2016-02-17 00:00:00

abstract：:Tropical carbon emissions are largely derived from direct forest clearing processes. Yet, emissions from drought-induced forest fires are, usually, not included in national-level carbon emission inventories. Here we examine Brazilian Amazon drought impacts on fire incidence and associated forest fire carbon emissions ...

journal_title：Nature communications

authors： Aragão LEOC,Anderson LO,Fonseca MG,Rosan TM,Vedovato LB,Wagner FH,Silva CVJ,Silva Junior CHL,Arai E,Aguiar AP,Barlow J,Berenguer E,Deeter MN,Domingues LG,Gatti L,Gloor M,Malhi Y,Marengo JA,Miller JB,Phillips OL,Sa

更新日期：2018-02-13 00:00:00

abstract：:Expression of oestrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy, but does not guarantee patient response. The molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here we characterize the DNA methylome of endocr...

journal_title：Nature communications

authors： Stone A,Zotenko E,Locke WJ,Korbie D,Millar EK,Pidsley R,Stirzaker C,Graham P,Trau M,Musgrove EA,Nicholson RI,Gee JM,Clark SJ

更新日期：2015-07-14 00:00:00

abstract：:The study of carrier multiplication has become an essential part of many-body physics and materials science as this multiplication directly affects nonlinear transport phenomena, and has a key role in designing efficient solar cells and electroluminescent emitters and highly sensitive photon detectors. Here we show th...

journal_title：Nature communications

authors： Hirori H,Shinokita K,Shirai M,Tani S,Kadoya Y,Tanaka K

更新日期：2011-12-20 00:00:00

abstract：:The costs for solar photovoltaics, wind, and battery storage have dropped markedly since 2010, however, many recent studies and reports around the world have not adequately captured such dramatic decrease. Those costs are projected to decline further in the near future, bringing new prospects for the widespread penetr...

journal_title：Nature communications

authors： He G,Lin J,Sifuentes F,Liu X,Abhyankar N,Phadke A

更新日期：2020-05-19 00:00:00

abstract：:The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the v...

journal_title：Nature communications

authors： Lamprecht DA,Finin PM,Rahman MA,Cumming BM,Russell SL,Jonnala SR,Adamson JH,Steyn AJ

更新日期：2016-08-10 00:00:00

abstract：:Bacterial CRISPR-Cas systems comprise diverse effector endonucleases with different targeting ranges, specificities and enzymatic properties, but many of them are inactive in mammalian cells and are thus precluded from genome-editing applications. Here we show that the type II-B FnCas9 from Francisella novicida posses...

journal_title：Nature communications

authors： Chen F,Ding X,Feng Y,Seebeck T,Jiang Y,Davis GD

更新日期：2017-04-07 00:00:00

abstract：:Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid) can induce strong production of IFNα/β and rejection of transplanted primary tumors. In the present study, we address whether targeting...

journal_title：Nature communications

authors： Guerin MV,Regnier F,Feuillet V,Vimeux L,Weiss JM,Bismuth G,Altan-Bonnet G,Guilbert T,Thoreau M,Finisguerra V,Donnadieu E,Trautmann A,Bercovici N

更新日期：2019-09-11 00:00:00

abstract：:Despite over a century of interest, the function of zebra stripes has never been examined systematically. Here we match variation in striping of equid species and subspecies to geographic range overlap of environmental variables in multifactor models controlling for phylogeny to simultaneously test the five major expl...

journal_title：Nature communications

authors： Caro T,Izzo A,Reiner RC Jr,Walker H,Stankowich T

更新日期：2014-04-01 00:00:00

abstract：:Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/r...

journal_title：Nature communications

authors： Siddiqi FH,Menzies FM,Lopez A,Stamatakou E,Karabiyik C,Ureshino R,Ricketts T,Jimenez-Sanchez M,Esteban MA,Lai L,Tortorella MD,Luo Z,Liu H,Metzakopian E,Fernandes HJR,Bassett A,Karran E,Miller BL,Fleming A,Rubinsztei

更新日期：2019-04-18 00:00:00

abstract：:Topological defects in nematic liquid crystals are ubiquitous. The defects are important in understanding the fundamental properties of the systems, as well as in practical applications, such as colloidal self-assembly, optical vortex generation and templates for molecular self-assembly. Usually, spatially and tempora...

journal_title：Nature communications

authors： Sasaki Y,Jampani VSR,Tanaka C,Sakurai N,Sakane S,Le KV,Araoka F,Orihara H

更新日期：2016-11-07 00:00:00

abstract：:As in human speech acquisition, songbird vocal learning depends on early auditory experience. During development, juvenile songbirds listen to and form auditory memories of adult tutor songs, which they use to shape their own vocalizations in later sensorimotor learning. The higher-level auditory cortex, called the ca...

journal_title：Nature communications

authors： Yanagihara S,Yazaki-Sugiyama Y

更新日期：2016-06-21 00:00:00

abstract：:Chloroplast function requires the coordinated action of nuclear- and chloroplast-derived proteins, including several hundred nuclear-encoded pentatricopeptide repeat (PPR) proteins that regulate plastid mRNA metabolism. Despite their large number and importance, regulatory mechanisms controlling PPR expression are poo...

journal_title：Nature communications

authors： Bailey M,Ivanauskaite A,Grimmer J,Akintewe O,Payne AC,Osborne R,Labandera AM,Etherington RD,Rantala M,Baginsky S,Mulo P,Gibbs DJ

更新日期：2021-01-11 00:00:00

abstract：:Express delivery services are booming in both developed and emerging economies due to their low cost, convenience, and the fast growth in online shopping. The increasing environmental impacts of express delivery services and mitigation potentials, however, remain largely unexplored. Here we addressed such a gap for Ch...

journal_title：Nature communications

authors： Kang P,Song G,Xu M,Miller TR,Wang H,Zhang H,Liu G,Zhou Y,Ren J,Zhong R,Duan H

更新日期：2021-01-19 00:00:00

abstract：:Coelacanths are known for their evolutionary conservatism, and the body plan seen in Latimeria can be traced to late Middle Devonian Diplocercides, Holopterygius and presumably Euporosteus. However, the group's early history is unclear because of an incomplete fossil record. Until now, the only Early Devonian coelacan...

journal_title：Nature communications

authors： Zhu M,Yu X,Lu J,Qiao T,Zhao W,Jia L

更新日期：2012-04-10 00:00:00

abstract：:Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. ...

journal_title：Nature communications

authors： Liu W,Li Y,Shaw KS,Learn GH,Plenderleith LJ,Malenke JA,Sundararaman SA,Ramirez MA,Crystal PA,Smith AG,Bibollet-Ruche F,Ayouba A,Locatelli S,Esteban A,Mouacha F,Guichet E,Butel C,Ahuka-Mundeke S,Inogwabini BI,Ndjango

更新日期：2014-01-01 00:00:00

abstract：:The negative-capacitance field-effect transistor(NC-FET) has attracted tremendous research efforts. However, the lack of a clear physical picture and design rule for this device has led to numerous invalid fabrications. In this work, we address this issue based on an unexpectedly concise and insightful analytical form...

journal_title：Nature communications

authors： Cao W,Banerjee K

更新日期：2020-01-10 00:00:00

abstract：:Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the choles...

journal_title：Nature communications

authors： Mahoney CE,Pirman D,Chubukov V,Sleger T,Hayes S,Fan ZP,Allen EL,Chen Y,Huang L,Liu M,Zhang Y,McDonald G,Narayanaswamy R,Choe S,Chen Y,Gross S,Cianchetta G,Padyana AK,Murray S,Liu W,Marks KM,Murtie J,Dorsch M,

更新日期：2019-01-09 00:00:00

abstract：:Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N2O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by micr...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-03-20 00:00:00

abstract：:The continuum hypothesis states that both deterministic and stochastic processes contribute to the assembly of ecological communities. However, the contextual dependency of these processes remains an open question that imposes strong limitations on predictions of community responses to environmental change. Here we me...

journal_title：Nature communications

authors： Powell JR,Karunaratne S,Campbell CD,Yao H,Robinson L,Singh BK

更新日期：2015-10-05 00:00:00

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:The growing realization of a looming biodiversity crisis has inspired considerable progress in the quest to link biodiversity, structure and ecosystem function. Here we construct a method that bridges low- and high-diversity approaches to food web theory by elucidating the connection between the stability of the basic...

journal_title：Nature communications

authors： Gellner G,McCann KS

更新日期：2016-04-12 00:00:00

abstract：:Surface and subsurface are commonly considered as separate entities because of the difference in the bonding environment and are often investigated separately due to the experimental challenges in differentiating the surface and subsurface effects. Using in-situ atomic-scale transmission electron microscopy to resolve...

journal_title：Nature communications

authors： Sun X,Zhu W,Wu D,Li C,Wang J,Zhu Y,Chen X,Boscoboinik JA,Sharma R,Zhou G

更新日期：2020-01-16 00:00:00

abstract：:The flexibility in structural design of organic semiconductors endows organic solar cells (OSCs) not only great function-tunabilities, but also high potential toward practical application. In this work, simple non-fused-ring electron acceptors are developed through two-step synthesis from single aromatic units for con...

journal_title：Nature communications

authors： Yu ZP,Liu ZX,Chen FX,Qin R,Lau TK,Yin JL,Kong X,Lu X,Shi M,Li CZ,Chen H

更新日期：2019-05-14 00:00:00

abstract：:It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This 'reverse transduction' force production has never been demonstrated experimentally, however, in the living...

journal_title：Nature communications

authors： Ren T,He W,Barr-Gillespie PG

更新日期：2016-01-06 00:00:00

abstract：:Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, here we identify PWW...

journal_title：Nature communications

authors： Zhang T,Wei G,Millard CJ,Fischer R,Konietzny R,Kessler BM,Schwabe JWR,Brockdorff N

更新日期：2018-09-18 00:00:00