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Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.

Abstract：

:γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1+ T cells have therefore evolved a distinct biology from the Vδ2+ subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance.

journal_name

Nat Commun

journal_title

Nature communications

authors

Davey MS,Willcox CR,Joyce SP,Ladell K,Kasatskaya SA,McLaren JE,Hunter S,Salim M,Mohammed F,Price DA,Chudakov DM,Willcox BE

doi

10.1038/ncomms14760

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

14760

issn

2041-1723

pii

ncomms14760

journal_volume

8

pub_type

杂志文章

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