Abstract:
:This corrects the article DOI: 10.1038/ncomms15317.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lovrak M,Hendriksen WEJ,Maity C,Mytnyk S,van Steijn V,Eelkema R,van Esch JHdoi
10.1038/ncomms16128subject
Has Abstractpub_date
2017-06-30 00:00:00pages
16128issn
2041-1723pii
ncomms16128journal_volume
8pub_type
杂志文章,已发布勘误abstract::DNA methylation plays important roles in prokaryotes, and their genomic landscapes-prokaryotic epigenomes-have recently begun to be disclosed. However, our knowledge of prokaryotic methylation systems is focused on those of culturable microbes, which are rare in nature. Here, we used single-molecule real-time and circ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08103-y
更新日期:2019-01-11 00:00:00
abstract::Cotton is an important natural fiber crop, however, its comprehensive and high-resolution gene map is lacking. Here we integrate four complementary high-throughput techniques, including Pacbio long read Iso-seq, strand-specific RNA-seq, CAGE-seq, and PolyA-seq, to systematically explore the transcription landscape acr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12575-x
更新日期:2019-10-17 00:00:00
abstract::The Schrödinger equation is a fundamental equation to describe the wave function of a quantum-mechanical system. The similar forms between the Schrödinger equation and the paraxial wave equation allow a paradigm shift from the quantum mechanics to classical fields, opening up a plethora of interesting phenomena includ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11430-3
更新日期:2019-07-30 00:00:00
abstract::A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15868
更新日期:2017-06-19 00:00:00
abstract::A key element enabling the microelectronic technology advances of the past decades has been the conceptualization of complex circuits with versatile functionalities as being composed of the proper combination of basic 'lumped' circuit elements (for example, inductors and capacitors). In contrast, modern nanophotonic s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4896
更新日期:2014-05-29 00:00:00
abstract::Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05795-0
更新日期:2018-08-22 00:00:00
abstract::The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution fea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11306
更新日期:2016-06-27 00:00:00
abstract::Microorganisms form biofilms containing differentiated cell populations. To determine factors driving differentiation, we herein visualize protein and metal distributions within Pseudomonas aeruginosa biofilms using imaging mass spectrometry. These in vitro experiments reveal correlations between differential protein ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11951
更新日期:2016-06-15 00:00:00
abstract::Turgor pressure plays pivotal roles in the growth and movement of walled cells that make up plants and fungi. However, the molecular mechanisms regulating turgor pressure and the coordination between turgor pressure and cell wall remodelling for cell growth remain poorly understood. Here, we report the characterizatio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7030
更新日期:2015-01-16 00:00:00
abstract::The application of electron microscopy to hydrated biological samples has been limited by high-vacuum operating conditions. Traditional methods utilize harsh and laborious sample dehydration procedures, often leading to structural artefacts and creating difficulties for correlating results with high-resolution fluores...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8384
更新日期:2015-06-11 00:00:00
abstract::To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12394
更新日期:2016-08-03 00:00:00
abstract::Pulses of tree mortality caused by drought have been reported recently in forests around the globe, but large-scale quantitative evidence is lacking for Europe. Analyzing high-resolution annual satellite-based canopy mortality maps from 1987 to 2016 we here show that excess forest mortality (i.e., canopy mortality exc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19924-1
更新日期:2020-12-03 00:00:00
abstract::Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12554
更新日期:2016-09-13 00:00:00
abstract::Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (APLN) is robustly expressed in vascular ECs. In adult mice, however, APLN expression in the vasculature is significantly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7020
更新日期:2015-01-19 00:00:00
abstract::Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16805-5
更新日期:2020-06-12 00:00:00
abstract::In weakly spin-orbit coupled materials, the spin-selective nature of recombination can give rise to large magnetic-field effects, e.g. on the electro-luminescence of molecular semiconductors. Although silicon has weak spin-orbit coupling, observing spin-dependent recombination through magneto-electroluminescence is ch...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02804-6
更新日期:2018-01-26 00:00:00
abstract::Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must recognize multiple ch...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15455-x
更新日期:2020-04-07 00:00:00
abstract::The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materials. In view of its limitations, we report here a rapid in vitro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09673-1
更新日期:2019-05-02 00:00:00
abstract::2,3-Dihydrobenzofurans and indolines are common substructures in medicines and natural products. Herein, we describe a method that enables direct access to these core structures from non-conjugated alkenyl amides and ortho-iodoanilines/phenols. Under palladium(II) catalysis this [3 + 2] heteroannulation proceeds in an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20182-4
更新日期:2020-12-22 00:00:00
abstract::The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array. Here, we report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organiza...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19628-6
更新日期:2020-11-13 00:00:00
abstract::Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC loss. Suppression of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16858-6
更新日期:2020-06-19 00:00:00
abstract::Noble metal nanoparticles stabilized by organic ligands are important for applications in assembly, site-specific bioconjugate labelling and sensing, drug delivery and medical therapy, molecular recognition and molecular electronics, and catalysis. Here we report crystal structures and theoretical analysis of three Ag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3422
更新日期:2013-01-01 00:00:00
abstract::The allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are currently available. Here we report high-quality draft genomes for three main tobacco varieties. These genomes show both the low divergence of tobacco from its ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4833
更新日期:2014-05-08 00:00:00
abstract::Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carry...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04238-0
更新日期:2018-05-04 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms15587. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms16220
更新日期:2018-07-13 00:00:00
abstract::Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06354-3
更新日期:2018-10-01 00:00:00
abstract::Genomic imprinting is a phenomenon that restricts transcription to predominantly one parental allele. How this transcriptional duality is regulated is poorly understood. Here we perform an RNA interference screen for epigenetic factors involved in paternal allelic silencing at the Kcnq1ot1 imprinted domain in mouse ex...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05208-2
更新日期:2018-07-18 00:00:00
abstract::Simultaneous deep brain stimulation (DBS) and functional magnetic resonance imaging (fMRI) constitutes a powerful tool for elucidating brain functional connectivity, and exploring neuromodulatory mechanisms of DBS therapies. Previous DBS-fMRI studies could not provide full activation pattern maps due to poor MRI compa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15570-9
更新日期:2020-04-14 00:00:00
abstract::Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56A...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12400-5
更新日期:2019-09-26 00:00:00
abstract::The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscill...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03574-5
更新日期:2018-03-23 00:00:00