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TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster.

Abstract：

:Translationally controlled tumour protein (TCTP) is implicated in growth regulation and cancer. Recently, human TCTP has been suggested to play a role in the DNA damage response by forming a complex with ataxia telangiectasia-mutated (ATM) kinase . However, the exact nature of this interaction and its roles in vivo remained unclear. Here, we utilize Drosophila as an animal model to study the nuclear function of Drosophila TCTP (dTCTP). dTCTP mutants show increased radiation sensitivity during development as well as strong genetic interaction with dATM mutations, resulting in severe defects in developmental timing, organ size and chromosome stability. We identify Drosophila ATM (dATM) as a direct binding partner of dTCTP and describe a mechanistic basis for dATM activation by dTCTP. Altogether, this study provides the first in vivo evidence for direct modulation of dATM activity by dTCTP in the control of genome stability and organ development.

journal_name

Nat Commun

journal_title

Nature communications

authors

Hong ST,Choi KW

doi

10.1038/ncomms3986

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2986

issn

2041-1723

pii

ncomms3986

journal_volume

4

pub_type

杂志文章

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