Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays.

abstract：:Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time...

journal_title：Nature communications

authors： Galenkamp NS,Soskine M,Hermans J,Wloka C,Maglia G

更新日期：2018-10-05 00:00:00

abstract：:Seismic tomography provides unique constraints on the morphology, the deformation, and (indirectly) the rheology of subducting slabs. We use teleseismic double-difference P-wave tomography to image with unprecedented clarity the structural complexity of the Izu-Bonin slab. We resolve a tear in the slab in the mantle t...

journal_title：Nature communications

authors： Zhang H,Wang F,Myhill R,Guo H

更新日期：2019-03-21 00:00:00

abstract：:Modern geophysics highlights that the slip behaviour response of faults is variable in space and time and can result in slow or fast ruptures. However, the origin of this variation of the rupture velocity in nature as well as the physics behind it is still debated. Here, we first highlight how the different types of f...

journal_title：Nature communications

authors： Passelègue FX,Almakari M,Dublanchet P,Barras F,Fortin J,Violay M

更新日期：2020-10-12 00:00:00

abstract：:Recent discovery of the half quantized thermal Hall conductivity in [Formula: see text]-RuCl[Formula: see text], a candidate material for the Kitaev spin liquid, suggests the presence of a highly entangled quantum state in external magnetic fields. This field induced phase appears between the low field zig-zag magneti...

journal_title：Nature communications

authors： Lee HY,Kaneko R,Chern LE,Okubo T,Yamaji Y,Kawashima N,Kim YB

更新日期：2020-04-02 00:00:00

abstract：:All-inorganic perovskites have a special place in halide perovskite family because of their potential for better stability. However, the representative cesium lead iodide (CsPbI3) is metastable and spontaneously converts to the non-perovskite structure at room temperature. Here, we demonstrate that what appears to be ...

journal_title：Nature communications

authors： Ke W,Spanopoulos I,Stoumpos CC,Kanatzidis MG

更新日期：2018-11-14 00:00:00

abstract：:Quantum magnets provide the simplest example of strongly interacting quantum matter, yet they continue to resist a comprehensive understanding above one spatial dimension. We explore a promising framework in two dimensions, the Dirac spin liquid (DSL) - quantum electrodynamics (QED3) with 4 Dirac fermions coupled to p...

journal_title：Nature communications

authors： Song XY,Wang C,Vishwanath A,He YC

更新日期：2019-09-18 00:00:00

abstract：:Current knowledge on chromosomal mosaicism in human cell cultures is mostly based on cytogenetic banding methods. The recent development of high-resolution full-genome analysis methods applicable to single cells is providing new insights into genetic and cellular diversity. Here we study the genetic content of 92 indi...

journal_title：Nature communications

authors： Jacobs K,Mertzanidou A,Geens M,Nguyen HT,Staessen C,Spits C

更新日期：2014-06-27 00:00:00

abstract：:The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the ant...

journal_title：Nature communications

authors： Zhang S,Kostyuchenko VA,Ng TS,Lim XN,Ooi JSG,Lambert S,Tan TY,Widman DG,Shi J,Baric RS,Lok SM

更新日期：2016-11-24 00:00:00

abstract：:The plasma membrane is uniquely enriched in phosphatidylserine (PtdSer). This anionic phospholipid is restricted almost exclusively to the inner leaflet of the plasmalemma. Because of their high density, the headgroups of anionic lipids experience electrostatic repulsion that, being exerted asymmetrically, is predicte...

journal_title：Nature communications

authors： Hirama T,Lu SM,Kay JG,Maekawa M,Kozlov MM,Grinstein S,Fairn GD

更新日期：2017-11-09 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...

journal_title：Nature communications

authors： Dallari S,Macal M,Loureiro ME,Jo Y,Swanson L,Hesser C,Ghosh P,Zuniga EI

更新日期：2017-04-03 00:00:00

abstract：:Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...

journal_title：Nature communications

authors： Kang J,He S,Zhou W,Shen Z,Li Y,Chen M,Zhang Q,Wang Y

更新日期：2020-02-11 00:00:00

abstract：:The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...

journal_title：Nature communications

authors： Cacheiro P,Muñoz-Fuentes V,Murray SA,Dickinson ME,Bucan M,Nutter LMJ,Peterson KA,Haselimashhadi H,Flenniken AM,Morgan H,Westerberg H,Konopka T,Hsu CW,Christiansen A,Lanza DG,Beaudet AL,Heaney JD,Fuchs H,Gailus-Durner

更新日期：2020-01-31 00:00:00

abstract：:The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis that negatively regulates cell growth and survival. Here we report that Yes-associated protein (YAP), the terminal effector of the Hippo pathway, interacts with FoxO1 in the nucleus of cardiomyocytes, thereby promoting survival....

journal_title：Nature communications

authors： Shao D,Zhai P,Del Re DP,Sciarretta S,Yabuta N,Nojima H,Lim DS,Pan D,Sadoshima J

更新日期：2014-01-01 00:00:00

abstract：:In eukaryotic cells, organellar proteome biogenesis is pivotal for cellular function. Chloroplasts contain a complex proteome, the biogenesis of which includes post-translational import of nuclear-encoded proteins. However, the mechanisms determining when and how nascent chloroplast-targeted proteins are sorted in the...

journal_title：Nature communications

authors： Kim DH,Lee JE,Xu ZY,Geem KR,Kwon Y,Park JW,Hwang I

更新日期：2015-04-16 00:00:00

abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

journal_title：Nature communications

authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

更新日期：2018-09-13 00:00:00

abstract：:Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage. Molecular mechanism(s) underlying such homology-dependent pairing phenomena remain(s) unknown. Using Neurospora crassa repeat-induced point mutation (RIP) as a model ...

journal_title：Nature communications

authors： Gladyshev E,Kleckner N

更新日期：2014-04-03 00:00:00

abstract：:The lack of microbial genomes and isolates from the deep seabed means that very little is known about the ecology of this vast habitat. Here, we investigate energy and carbon acquisition strategies of microbial communities from three deep seabed petroleum seeps (3 km water depth) in the Eastern Gulf of Mexico. Shotgun...

journal_title：Nature communications

authors： Dong X,Greening C,Rattray JE,Chakraborty A,Chuvochina M,Mayumi D,Dolfing J,Li C,Brooks JM,Bernard BB,Groves RA,Lewis IA,Hubert CRJ

更新日期：2019-04-18 00:00:00

abstract：:Holocene summer temperature reconstructions from northern Europe based on sedimentary pollen records suggest an onset of peak summer warmth around 9,000 years ago. However, pollen-based temperature reconstructions are largely driven by changes in the proportions of tree taxa, and thus the early-Holocene warming signal...

journal_title：Nature communications

authors： Väliranta M,Salonen JS,Heikkilä M,Amon L,Helmens K,Klimaschewski A,Kuhry P,Kultti S,Poska A,Shala S,Veski S,Birks HH

更新日期：2015-04-10 00:00:00

abstract：:The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tum...

journal_title：Nature communications

authors： Woodcock DJ,Riabchenko E,Taavitsainen S,Kankainen M,Gundem G,Brewer DS,Ellonen P,Lepistö M,Golubeva YA,Warner AC,Tolonen T,Jasu J,Isaacs WB,Emmert-Buck MR,Nykter M,Visakorpi T,Bova GS,Wedge DC

更新日期：2020-10-08 00:00:00

abstract：:Phospholipids are elemental building-block molecules for biological membranes. Biosynthesis of phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthetase (Cds) is an integral membrane enzym...

journal_title：Nature communications

authors： Liu X,Yin Y,Wu J,Liu Z

更新日期：2014-06-27 00:00:00

abstract：:Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...

journal_title：Nature communications

authors： Yan K,Wu D,Peng H,Jin L,Fu Q,Bao X,Liu Z

更新日期：2012-01-01 00:00:00

abstract：:Chemical synthesis of amino acids from renewable sources is an alternative route to the current processes based on fermentation. Here, we report visible-light-driven amination of biomass-derived α-hydroxyl acids and glucose into amino acids using NH3 at 50 °C. Ultrathin CdS nanosheets are identified as an efficient an...

journal_title：Nature communications

authors： Song S,Qu J,Han P,Hülsey MJ,Zhang G,Wang Y,Wang S,Chen D,Lu J,Yan N

更新日期：2020-09-29 00:00:00

abstract：:Much of the world's Li deposits occurs as basinal brines in magmatic orogens, particularly in continental volcanic arcs. However, the exact origin of Li enrichment in arc magmatic systems is not clear. Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios similar to mid-ocean ridge basalt...

journal_title：Nature communications

authors： Chen C,Lee CA,Tang M,Biddle K,Sun W

更新日期：2020-10-20 00:00:00

abstract：:The actin-like protein MreB has been proposed to coordinate the synthesis of the cell wall to determine cell shape in bacteria. MreB is preferentially localized to areas of the cell with specific curved geometries, avoiding the cell poles. It remains unclear whether MreB's curvature preference is regulated by addition...

journal_title：Nature communications

authors： Bratton BP,Shaevitz JW,Gitai Z,Morgenstein RM

更新日期：2018-07-18 00:00:00

abstract：:No method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in ...

journal_title：Nature communications

authors： Fremin BJ,Sberro H,Bhatt AS

更新日期：2020-06-29 00:00:00

abstract：:Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of the kidney remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic and structural heterogeneity of the kidney vasculature are unknown. Here, we employ high-throughput bulk and...

journal_title：Nature communications

authors： Barry DM,McMillan EA,Kunar B,Lis R,Zhang T,Lu T,Daniel E,Yokoyama M,Gomez-Salinero JM,Sureshbabu A,Cleaver O,Di Lorenzo A,Choi ME,Xiang J,Redmond D,Rabbany SY,Muthukumar T,Rafii S

更新日期：2019-12-13 00:00:00

abstract：:Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by integrating genomics, transcriptomics and protein profiling including modifications by mass spectrometry (MS). A critical limitation is sample input requirements that exceed many sources of clinically important material. Here we ...

journal_title：Nature communications

authors： Satpathy S,Jaehnig EJ,Krug K,Kim BJ,Saltzman AB,Chan DW,Holloway KR,Anurag M,Huang C,Singh P,Gao A,Namai N,Dou Y,Wen B,Vasaikar SV,Mutch D,Watson MA,Ma C,Ademuyiwa FO,Rimawi MF,Schiff R,Hoog J,Jacobs S,Malov

更新日期：2020-01-27 00:00:00

abstract：:Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...

journal_title：Nature communications

authors： Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

更新日期：2015-07-28 00:00:00

abstract：:Strategies to harness photosynthesis from living organisms to generate electrical power have long been considered, yet efficiency remains low. Here, we aimed to reroute photosynthetic electron flow in photosynthetic organisms without compromising their phototrophic properties. We show that 2,6-dimethyl-p-benzoquinone ...

journal_title：Nature communications

authors： Fu HY,Picot D,Choquet Y,Longatte G,Sayegh A,Delacotte J,Guille-Collignon M,Lemaître F,Rappaport F,Wollman FA

更新日期：2017-05-03 00:00:00

abstract：:Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically relevant, high-affinity version of the receptor ectodomain, th...

journal_title：Nature communications

authors： Weis F,Menting JG,Margetts MB,Chan SJ,Xu Y,Tennagels N,Wohlfart P,Langer T,Müller CW,Dreyer MK,Lawrence MC

更新日期：2018-10-24 00:00:00