WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.

abstract：:The El Niño-Southern Oscillation is the dominant mode of interannual climate variability across the Pacific Ocean basin, with influence on the global climate. The two end members of the cycle, El Niño and La Niña, force anomalous oceanographic conditions and coastal response along the Pacific margin, exposing many hea...

journal_title：Nature communications

authors： Barnard PL,Hoover D,Hubbard DM,Snyder A,Ludka BC,Allan J,Kaminsky GM,Ruggiero P,Gallien TW,Gabel L,McCandless D,Weiner HM,Cohn N,Anderson DL,Serafin KA

更新日期：2017-02-14 00:00:00

abstract：:Centromeres are specified epigenetically through the deposition of the centromere-specific histone H3 variant CENP-A. However, how additional epigenetic features are involved in centromere specification is unknown. Here, we find that histone H4 Lys5 and Lys12 acetylation (H4K5ac and H4K12ac) primarily occur within the...

journal_title：Nature communications

authors： Shang WH,Hori T,Westhorpe FG,Godek KM,Toyoda A,Misu S,Monma N,Ikeo K,Carroll CW,Takami Y,Fujiyama A,Kimura H,Straight AF,Fukagawa T

更新日期：2016-11-04 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. We have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one o...

journal_title：Nature communications

authors： Mondal T,Subhash S,Vaid R,Enroth S,Uday S,Reinius B,Mitra S,Mohammed A,James AR,Hoberg E,Moustakas A,Gyllensten U,Jones SJ,Gustafsson CM,Sims AH,Westerlund F,Gorab E,Kanduri C

更新日期：2015-07-24 00:00:00

abstract：:Melanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation. Here we show that ADAR1 silencing enhances melanoma cell in...

journal_title：Nature communications

authors： Nemlich Y,Baruch EN,Besser MJ,Shoshan E,Bar-Eli M,Anafi L,Barshack I,Schachter J,Ortenberg R,Markel G

更新日期：2018-05-31 00:00:00

abstract：:Steels belong to one of the best established materials, however, the mechanisms of various phase transformations down to the nano length scale are still not fully clear. In this work, high-resolution transmission electron microscopy is combined with atomistic simulations to study the nanoscale carbide precipitation in...

journal_title：Nature communications

authors： Wang H,Zhang X,Yan D,Somsen C,Eggeler G

更新日期：2018-10-01 00:00:00

abstract：:Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely ap...

journal_title：Nature communications

authors： Schäfer P,Palacin T,Sidera M,Fletcher SP

更新日期：2017-06-13 00:00:00

abstract：:Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of ...

journal_title：Nature communications

authors： Adhireksan Z,Palermo G,Riedel T,Ma Z,Muhammad R,Rothlisberger U,Dyson PJ,Davey CA

更新日期：2017-03-30 00:00:00

abstract：:Acid sphingomyelinase (ASMase, ASM, SMPD1) converts sphingomyelin into ceramide, modulating membrane properties and signal transduction. Inactivating mutations in ASMase cause Niemann-Pick disease, and its inhibition is also beneficial in models of depression and cancer. To gain a better understanding of this critical...

journal_title：Nature communications

authors： Gorelik A,Illes K,Heinz LX,Superti-Furga G,Nagar B

更新日期：2016-07-20 00:00:00

abstract：:A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation of nucleoids are thought to be passively determined by mitochondrial fusion and division. Here we provide evidence, using live-cell super-resolution imaging, that nucleoids can be...

journal_title：Nature communications

authors： Qin J,Guo Y,Xue B,Shi P,Chen Y,Su QP,Hao H,Zhao S,Wu C,Yu L,Li D,Sun Y

更新日期：2020-09-08 00:00:00

abstract：:Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate...

journal_title：Nature communications

authors： Mika-Gospodorz B,Giengkam S,Westermann AJ,Wongsantichon J,Kion-Crosby W,Chuenklin S,Wang LC,Sunyakumthorn P,Sobota RM,Subbian S,Vogel J,Barquist L,Salje J

更新日期：2020-07-03 00:00:00

abstract：:Modern ultrafast metrology relies on the postulate that the pulse to be measured is fully coherent, that is, that it can be completely described by its spectrum and spectral phase. However, synthesizing fully coherent pulses is not always possible in practice, especially in the domain of emerging ultrashort X-ray sour...

journal_title：Nature communications

authors： Bourassin-Bouchet C,Couprie ME

更新日期：2015-03-06 00:00:00

abstract：:Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (...

journal_title：Nature communications

authors： Blomme A,Ford CA,Mui E,Patel R,Ntala C,Jamieson LE,Planque M,McGregor GH,Peixoto P,Hervouet E,Nixon C,Salji M,Gaughan L,Markert E,Repiscak P,Sumpton D,Blanco GR,Lilla S,Kamphorst JJ,Graham D,Faulds K,MacKay GM,

更新日期：2020-05-19 00:00:00

abstract：:Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas. Understanding mechanisms of piperaquine (PPQ) resistance is crucial for tracking its emergence and spread, and to develop effective strategies for overcoming it. He...

journal_title：Nature communications

authors： Bopp S,Magistrado P,Wong W,Schaffner SF,Mukherjee A,Lim P,Dhorda M,Amaratunga C,Woodrow CJ,Ashley EA,White NJ,Dondorp AM,Fairhurst RM,Ariey F,Menard D,Wirth DF,Volkman SK

更新日期：2018-05-02 00:00:00

abstract：:CRISPR/Cas9 has demonstrated a high-efficiency in site-specific gene targeting. However, potential off-target effects of the Cas9 nuclease represent a major safety concern for any therapeutic application. Here, we knock out the Tafazzin gene by CRISPR/Cas9 in human-induced pluripotent stem cells with 54% efficiency. W...

journal_title：Nature communications

authors： Yang L,Grishin D,Wang G,Aach J,Zhang CZ,Chari R,Homsy J,Cai X,Zhao Y,Fan JB,Seidman C,Seidman J,Pu W,Church G

更新日期：2014-11-26 00:00:00

abstract：:The Nrf2 transcription factor controls the expression of genes involved in the antioxidant defense system. Here, we identified Nrf2 as a novel regulator of desmosomes in the epidermis through the regulation of microRNAs. On Nrf2 activation, expression of miR-29a and miR-29b increases in cultured human keratinocytes an...

journal_title：Nature communications

authors： Kurinna S,Schäfer M,Ostano P,Karouzakis E,Chiorino G,Bloch W,Bachmann A,Gay S,Garrod D,Lefort K,Dotto GP,Beer HD,Werner S

更新日期：2014-10-06 00:00:00

abstract：:Many low-thermal-conductivity (κL) crystals show intriguing temperature (T) dependence of κL: κL ∝ T-1 (crystal-like) at intermediate temperatures whereas weak T-dependence (glass-like) at high temperatures. It has been in debate whether thermal transport can still be described by phonons at the Ioffe-Regel limit. In ...

journal_title：Nature communications

authors： Luo Y,Yang X,Feng T,Wang J,Ruan X

更新日期：2020-05-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Hirata M,Asano N,Katayama K,Yoshida A,Tsuda Y,Sekimizu M,Mitani S,Kobayashi E,Komiyama M,Fujimoto H,Goto T,Iwamoto Y,Naka N,Iwata S,Nishida Y,Hiruma T,Hiraga H,Kawano H,Motoi T,Oda Y,Matsubara D,Fujita M,Shiba

更新日期：2020-02-19 00:00:00

abstract：:The ever-increasing demand for flexible electronics calls for the development of low-voltage and high-mobility organic thin-film transistors (OTFTs) that can be integrated into emerging display and labeling technologies. Polymer dielectrics with comprehensive and balanced dielectric properties (i.e., a good balance be...

journal_title：Nature communications

authors： Ji D,Li T,Zou Y,Chu M,Zhou K,Liu J,Tian G,Zhang Z,Zhang X,Li L,Wu D,Dong H,Miao Q,Fuchs H,Hu W

更新日期：2018-06-14 00:00:00

abstract：:Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...

journal_title：Nature communications

authors： Grivas C,Li C,Andreakou P,Wang P,Ding M,Brambilla G,Manna L,Lagoudakis P

更新日期：2013-01-01 00:00:00

abstract：:The Arctic marine biome, shrinking with increasing temperature and receding sea-ice cover, is tightly connected to lower latitudes through the North Atlantic. By flowing northward through the European Arctic Corridor (the main Arctic gateway where 80% of in- and outflow takes place), the North Atlantic Waters transpor...

journal_title：Nature communications

authors： Oziel L,Baudena A,Ardyna M,Massicotte P,Randelhoff A,Sallée JB,Ingvaldsen RB,Devred E,Babin M

更新日期：2020-04-06 00:00:00

abstract：:The use of graphene in electronic devices requires a band gap, which can be achieved by creating nanostructures such as graphene nanoribbons. A wide variety of atomically precise graphene nanoribbons can be prepared through on-surface synthesis, bringing the concept of graphene nanoribbon electronics closer to reality...

journal_title：Nature communications

authors： Jacobse PH,Kimouche A,Gebraad T,Ervasti MM,Thijssen JM,Liljeroth P,Swart I

更新日期：2017-07-25 00:00:00

abstract：:Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cell...

journal_title：Nature communications

authors： Yasumizu Y,Rajabi H,Jin C,Hata T,Pitroda S,Long MD,Hagiwara M,Li W,Hu Q,Liu S,Yamashita N,Fushimi A,Kui L,Samur M,Yamamoto M,Zhang Y,Zhang N,Hong D,Maeda T,Kosaka T,Wong KK,Oya M,Kufe D

更新日期：2020-01-17 00:00:00

abstract：:The realization that mitigation efforts to reduce carbon dioxide emissions have, until now, been relatively ineffective has led to an increasing interest in climate engineering as a possible means of preventing the potentially catastrophic consequences of climate change. While many studies have addressed the potential...

journal_title：Nature communications

authors： Keller DP,Feng EY,Oschlies A

更新日期：2014-02-25 00:00:00

abstract：:Topological insulators interacting with magnetic impurities have been reported to host several unconventional effects. These phenomena are described within the framework of gapping Dirac quasiparticles due to broken time-reversal symmetry. However, the overwhelming majority of studies demonstrate the presence of a fin...

journal_title：Nature communications

authors： Sessi P,Biswas RR,Bathon T,Storz O,Wilfert S,Barla A,Kokh KA,Tereshchenko OE,Fauth K,Bode M,Balatsky AV

更新日期：2016-06-27 00:00:00

abstract：:Pulsars are rotating neutron stars emitting lighthouse-like beams. Owing to their unique properties, pulsars are a unique astrophysical tool to test general relativity, inform on matter in extreme conditions, and probe galactic magnetic fields. Understanding pulsar physics and emission mechanisms is critical to these ...

journal_title：Nature communications

authors： Gueroult R,Shi Y,Rax JM,Fisch NJ

更新日期：2019-07-19 00:00:00

abstract：:The T helper 9 (Th9) cell transcriptional network is formed by an equilibrium of signals induced by cytokines and antigen presentation. Here we show that, within this network, two interferon regulatory factors (IRF), IRF1 and IRF4, display opposing effects on Th9 differentiation. IRF4 dose-dependently promotes, wherea...

journal_title：Nature communications

authors： Campos Carrascosa L,Klein M,Kitagawa Y,Lückel C,Marini F,König A,Guralnik A,Raifer H,Hagner-Benes S,Rädler D,Böck A,Kang C,Lohoff M,Garn H,Schaub B,Berberich-Siebelt F,Sakaguchi S,Bopp T,Huber M

更新日期：2017-05-12 00:00:00

abstract：:The gyrotropic rotation around the equilibrium position constitutes the fundamental excitation of magnetic vortices in nanostructures. The frequency of this mode varies with material and sample geometry, but is independent of the vortex handedness and its core direction. Here, we demonstrate that this degeneracy is li...

journal_title：Nature communications

authors： Sluka V,Kákay A,Deac AM,Bürgler DE,Schneider CM,Hertel R

更新日期：2015-03-03 00:00:00

abstract：:Understanding the formation chemistry of metal halide perovskites is key to optimizing processing conditions and realizing enhanced optoelectronic properties. Here, we reveal the structure of the crystalline precursor in the formation of methylammonium lead iodide (MAPbI3) from the single-step deposition of lead chlor...

journal_title：Nature communications

authors： Stone KH,Gold-Parker A,Pool VL,Unger EL,Bowring AR,McGehee MD,Toney MF,Tassone CJ

更新日期：2018-08-27 00:00:00

abstract：:Atherosclerosis is characterized by the accumulation of lipids within the arterial wall. Although activation of TRPV1 cation channels by capsaicin may reduce lipid storage and the formation of atherosclerotic lesions, a clinical use for capsaicin has been limited by its chronic toxicity. Here we show that coupling of ...

journal_title：Nature communications

authors： Gao W,Sun Y,Cai M,Zhao Y,Cao W,Liu Z,Cui G,Tang B

更新日期：2018-01-15 00:00:00

abstract：:The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...

journal_title：Nature communications

authors： Di Renzo M,Urzay J

更新日期：2018-05-21 00:00:00