Metabolic network analysis reveals microbial community interactions in anammox granules.

abstract：:Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, and introduce allele...

journal_title：Nature communications

authors： Bratic A,Kauppila TE,Macao B,Grönke S,Siibak T,Stewart JB,Baggio F,Dols J,Partridge L,Falkenberg M,Wredenberg A,Larsson NG

更新日期：2015-11-10 00:00:00

abstract：:Research results on the effects of land cover change on water resources vary greatly and the topic remains controversial. Here we use published data worldwide to examine the validity of Fuh's equation, which relates annual water yield (R) to a wetness index (precipitation/potential evapotranspiration; P/PET) and water...

journal_title：Nature communications

authors： Zhou G,Wei X,Chen X,Zhou P,Liu X,Xiao Y,Sun G,Scott DF,Zhou S,Han L,Su Y

更新日期：2015-01-09 00:00:00

abstract：:Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers on its basal plane, thus the best performing device currently relies on e...

journal_title：Nature communications

authors： Leng K,Wang L,Shao Y,Abdelwahab I,Grinblat G,Verzhbitskiy I,Li R,Cai Y,Chi X,Fu W,Song P,Rusydi A,Eda G,Maier SA,Loh KP

更新日期：2020-10-30 00:00:00

abstract：:The growth of large-domain single crystalline graphene with the controllable number of layers is of central importance for large-scale integration of graphene devices. Here we report a new pathway to greatly reduce the graphene nucleation density from ~10(6) to 4 nuclei cm(-2), enabling the growth of giant single crys...

journal_title：Nature communications

authors： Zhou H,Yu WJ,Liu L,Cheng R,Chen Y,Huang X,Liu Y,Wang Y,Huang Y,Duan X

更新日期：2013-01-01 00:00:00

abstract：:To balance immunity and tolerance, the endogenous pool of Foxp3+ regulatory T (Treg) cells is tightly controlled, but the underlying mechanisms of this control remain poorly understood. Here we show that the number of Treg cells is negatively regulated by the kinase Lkb1 in dendritic cells (DCs). Conditional knockout ...

journal_title：Nature communications

authors： Chen S,Fang L,Guo W,Zhou Y,Yu G,Li W,Dong K,Liu J,Luo Y,Wang B,Li Z,Zhao C,Sun Z,Shen Y,Leng Q,Zhou D,Han Z,Huang H,Ren H,Xu G,Feng X

更新日期：2018-12-13 00:00:00

abstract：:ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of mutant ASXL1 (ASXL1-MT) and BAP1 in promotin...

journal_title：Nature communications

authors： Asada S,Goyama S,Inoue D,Shikata S,Takeda R,Fukushima T,Yonezawa T,Fujino T,Hayashi Y,Kawabata KC,Fukuyama T,Tanaka Y,Yokoyama A,Yamazaki S,Kozuka-Hata H,Oyama M,Kojima S,Kawazu M,Mano H,Kitamura T

更新日期：2018-07-16 00:00:00

abstract：:Fusion proteins containing blue-light-activable protein domains possess great potential as molecular switches in cell signalling. This has recently been impressively demonstrated by connecting the light oxygen voltage LOV2-Jα-protein domain of A. sativa (AsLOV2-Jα) with the Rac1-GTPase, responsible for regulating the ...

journal_title：Nature communications

authors： Peter E,Dick B,Baeurle SA

更新日期：2010-11-16 00:00:00

abstract：:Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism ...

journal_title：Nature communications

authors： Liu W,Filimonov SN,Carrasco J,Tkatchenko A

更新日期：2013-01-01 00:00:00

abstract：:Recent studies suggest that attention samples space rhythmically through oscillatory interactions in the frontoparietal network. How these attentional fluctuations coincide with spatial exploration/displacement and exploitation/selection by a dynamic attentional spotlight under top-down control is unclear. Here, we sh...

journal_title：Nature communications

authors： Gaillard C,Ben Hadj Hassen S,Di Bello F,Bihan-Poudec Y,VanRullen R,Ben Hamed S

更新日期：2020-02-17 00:00:00

abstract：:Materials genomics represents a research mode for materials development, for which reliable methods for efficient materials construction are essential. Here we present a methodology for high-throughput construction of covalent organic frameworks (COFs) based on materials genomics strategy, in which a gene partition me...

journal_title：Nature communications

authors： Lan Y,Han X,Tong M,Huang H,Yang Q,Liu D,Zhao X,Zhong C

更新日期：2018-12-10 00:00:00

abstract：:The extraction of a clear and simple footprint of the structure of large, weighted and directed networks is a general problem that has relevance for many applications. An important example is seen in origin-destination matrices, which contain the complete information on commuting flows, but are difficult to analyze an...

journal_title：Nature communications

authors： Louail T,Lenormand M,Picornell M,García Cantú O,Herranz R,Frias-Martinez E,Ramasco JJ,Barthelemy M

更新日期：2015-01-21 00:00:00

abstract：:With damage tolerance rivalling advanced engineering alloys and thermoplastic forming capabilities analogous to conventional plastics, metallic glasses are emerging as a modern engineering material. Here, we take advantage of their unique electrical and rheological properties along with the classic Lorentz force conce...

journal_title：Nature communications

authors： Kaltenboeck G,Demetriou MD,Roberts S,Johnson WL

更新日期：2016-02-08 00:00:00

abstract：:Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of substrate compliance in live tissues has not been accomplished to date. Here we propose that stem cells can be regulated solely through in situ modulation of tissue biomechanics. By first establishing, via high-resolution Brillou...

journal_title：Nature communications

authors： Gouveia RM,Lepert G,Gupta S,Mohan RR,Paterson C,Connon CJ

更新日期：2019-04-03 00:00:00

abstract：:The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...

journal_title：Nature communications

authors： Adhikari S,Nice EC,Deutsch EW,Lane L,Omenn GS,Pennington SR,Paik YK,Overall CM,Corrales FJ,Cristea IM,Van Eyk JE,Uhlén M,Lindskog C,Chan DW,Bairoch A,Waddington JC,Justice JL,LaBaer J,Rodriguez H,He F,Kostrzewa M

更新日期：2020-10-16 00:00:00

abstract：:Cullin-RING ubiquitin ligases (CRLs) are critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL. The mechanistic link between Cullin neddylation and Myc ubiquitination/degradation is unclear. Here we show that Myc is a target of the CSN subunit 6 (CSN6)-Cullin signalling axi...

journal_title：Nature communications

authors： Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H

更新日期：2014-11-14 00:00:00

abstract：:Global fish production (capture and aquaculture) has increased quickly, which has altered global flows of phosphorus (P). Here we show that in 2016, [Formula: see text] Tg P yr-1 (mean and interquartile range) was applied in aquaculture to increase fish production; while [Formula: see text] Tg P yr-1 was removed from ...

journal_title：Nature communications

authors： Huang Y,Ciais P,Goll DS,Sardans J,Peñuelas J,Cresto-Aleina F,Zhang H

更新日期：2020-01-17 00:00:00

abstract：:Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cell...

journal_title：Nature communications

authors： Cerro-Herreros E,Sabater-Arcis M,Fernandez-Costa JM,Moreno N,Perez-Alonso M,Llamusi B,Artero R

更新日期：2018-06-26 00:00:00

abstract：:Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions. Through genome-wide miRNA mim...

journal_title：Nature communications

authors： Li Q,Lowey B,Sodroski C,Krishnamurthy S,Alao H,Cha H,Chiu S,El-Diwany R,Ghany MG,Liang TJ

更新日期：2017-11-27 00:00:00

abstract：:Pterosaurs, the first vertebrates to evolve active flight, lived between 210 and 66 million years ago. They were important components of Mesozoic ecosystems, and reconstructing pterosaur diets is vital for understanding their origins, their roles within Mesozoic food webs and the impact of other flying vertebrates (i....

journal_title：Nature communications

authors： Bestwick J,Unwin DM,Butler RJ,Purnell MA

更新日期：2020-10-28 00:00:00

abstract：:Ionic liquids (ILs) are emerging as superior solvents for numerous industrial applications, including the pretreatment of biomass for the microbial production of biofuels. However, some of the most effective ILs used to solubilize cellulose inhibit microbial growth, decreasing efficiency in the overall process. Here w...

journal_title：Nature communications

authors： Ruegg TL,Kim EM,Simmons BA,Keasling JD,Singer SW,Lee TS,Thelen MP

更新日期：2014-03-26 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00

abstract：:Increased aerobic glycolysis in endothelial cells of atheroprone areas of blood vessels has been hypothesized to drive increased inflammation and lesion burden but direct links remain to be established. Here we show that endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of prote...

journal_title：Nature communications

authors： Yang Q,Xu J,Ma Q,Liu Z,Sudhahar V,Cao Y,Wang L,Zeng X,Zhou Y,Zhang M,Xu Y,Wang Y,Weintraub NL,Zhang C,Fukai T,Wu C,Huang L,Han Z,Wang T,Fulton DJ,Hong M,Huo Y

更新日期：2018-11-07 00:00:00

abstract：:Knowledge of cell type composition in disease relevant tissues is an important step towards the identification of cellular targets of disease. We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type compositions from bulk RNA-...

journal_title：Nature communications

authors： Wang X,Park J,Susztak K,Zhang NR,Li M

更新日期：2019-01-22 00:00:00

abstract：:Tuning the thermodynamic state of a material has a tremendous impact on its performance. In the case of polymers placed in proximity of a solid wall, this is possible by annealing above the glass transition temperature, Tg, which induces the formation of an adsorbed layer. Whether heating to higher temperatures would ...

journal_title：Nature communications

authors： Monnier X,Napolitano S,Cangialosi D

更新日期：2020-08-28 00:00:00

abstract：:Light-phase-sensitive techniques, such as coherent multidimensional spectroscopy, are well-established in a broad spectral range, already spanning from radio-frequencies in nuclear magnetic resonance spectroscopy to visible and ultraviolet wavelengths in nonlinear optics with table-top lasers. In these cases, the abil...

journal_title：Nature communications

authors： Usenko S,Przystawik A,Jakob MA,Lazzarino LL,Brenner G,Toleikis S,Haunhorst C,Kip D,Laarmann T

更新日期：2017-05-30 00:00:00

abstract：:Research on surface plasmon resonance coupling of metallic nanostructures is an important area in the field of plasmonics because distinctive collective optical properties can be realized that are different from the individual constituents. Here we report the localized surface plasmon resonance of hybrid metal-organic...

journal_title：Nature communications

authors： Jung I,Kim M,Kwak M,Kim G,Jang M,Kim SM,Park DJ,Park S

更新日期：2018-03-08 00:00:00

abstract：:One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...

journal_title：Nature communications

authors： Valenza JM,Edmonds DA,Hwang T,Roy S

更新日期：2020-04-30 00:00:00

abstract：:Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of circulating tumor cell (CTC)-based liquid biopsy assays that provide accurate molecular data in guiding clinical decisions. Here we describe a method to preserve whol...

journal_title：Nature communications

authors： Wong KHK,Tessier SN,Miyamoto DT,Miller KL,Bookstaver LD,Carey TR,Stannard CJ,Thapar V,Tai EC,Vo KD,Emmons ES,Pleskow HM,Sandlin RD,Sequist LV,Ting DT,Haber DA,Maheswaran S,Stott SL,Toner M

更新日期：2017-11-23 00:00:00

abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

journal_title：Nature communications

authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

更新日期：2018-09-13 00:00:00

abstract：:Little is known about how our brains dynamically adapt for efficient functioning. Most previous work has focused on analyzing changes in co-fluctuations between a set of brain regions over several temporal segments of the data. We argue that by collapsing data in space or time, we stand to lose useful information abou...

journal_title：Nature communications

authors： Saggar M,Sporns O,Gonzalez-Castillo J,Bandettini PA,Carlsson G,Glover G,Reiss AL

更新日期：2018-04-11 00:00:00