Abstract：
:Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing normal cellular growth, differentiation and proliferation, with aberrant signalling implicated in cancer. Insulin-like growth factor binding is understood to relax conformational restraints within the homodimer, initiating transphosphorylation of the tyrosine kinase domains. However, no three-dimensional structures exist for the receptor ectodomain to inform atomic-level understanding of these events. Here, we present crystal structures of the ectodomain in apo form and in complex with insulin-like growth factor I, the latter obtained by crystal soaking. These structures not only provide a wealth of detail of the growth factor interaction with the receptor's primary ligand-binding site but also indicate that ligand binding separates receptor domains by a mechanism of induced fit. Our findings are of importance to the design of agents targeting IGF-1R and its partner protein, the human insulin receptor.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Xu Y,Kong GK,Menting JG,Margetts MB,Delaine CA,Jenkin LM,Kiselyov VV,De Meyts P,Forbes BE,Lawrence MCdoi
10.1038/s41467-018-03219-7subject
Has Abstractpub_date
2018-02-26 00:00:00pages
821issue
1issn
2041-1723pii
10.1038/s41467-018-03219-7journal_volume
9pub_type
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