Mineral phosphorus drives glacier algal blooms on the Greenland Ice Sheet.

abstract：:Rapid and, in many cases, unprecedented Arctic climate changes are having far-reaching impacts on natural and human systems. Despite state-of-the-art climate models capturing the rapid nature of Arctic climate change, termed Arctic amplification, they significantly disagree on its magnitude. Using a regional, process-...

journal_title：Nature communications

authors： Boeke RC,Taylor PC

更新日期：2018-11-27 00:00:00

abstract：:xrRNAs from flaviviruses survive in host cells because of their exceptional dichotomic response to the unfolding action of different enzymes. They can be unwound, and hence copied, by replicases, and yet can resist degradation by exonucleases. How the same stretch of xrRNA can encode such diverse responses is an open ...

journal_title：Nature communications

authors： Suma A,Coronel L,Bussi G,Micheletti C

更新日期：2020-07-27 00:00:00

abstract：:Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation effici...

journal_title：Nature communications

authors： Liu Z,Chen M,Chen S,Deng J,Song Y,Lai L,Li Z

更新日期：2018-07-13 00:00:00

abstract：:The ability to modulate light at high speeds is of paramount importance for telecommunications, information processing and medical imaging technologies. This has stimulated intense efforts to master optoelectronic switching at visible and near-infrared frequencies, although coping with current computer speeds in integ...

journal_title：Nature communications

authors： Manjavacas A,García de Abajo FJ

更新日期：2014-03-27 00:00:00

abstract：:The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the ant...

journal_title：Nature communications

authors： Zhang S,Kostyuchenko VA,Ng TS,Lim XN,Ooi JSG,Lambert S,Tan TY,Widman DG,Shi J,Baric RS,Lok SM

更新日期：2016-11-24 00:00:00

abstract：:According to quantum theory, measurements generate random outcomes, in stark contrast with classical mechanics. This raises the question of whether there could exist an extension of the theory that removes this indeterminism, as suspected by Einstein, Podolsky and Rosen. Although this has been shown to be impossible, ...

journal_title：Nature communications

authors： Colbeck R,Renner R

更新日期：2011-08-02 00:00:00

abstract：:Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activat...

journal_title：Nature communications

authors： Natsuizaka M,Whelan KA,Kagawa S,Tanaka K,Giroux V,Chandramouleeswaran PM,Long A,Sahu V,Darling DS,Que J,Yang Y,Katz JP,Wileyto EP,Basu D,Kita Y,Natsugoe S,Naganuma S,Klein-Szanto AJ,Diehl JA,Bass AJ,Wong KK,Rust

更新日期：2017-11-24 00:00:00

abstract：:Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elong...

journal_title：Nature communications

authors： Xu S,Zhan M,Jiang C,He M,Yang L,Shen H,Huang S,Huang X,Lin R,Shi Y,Liu Q,Chen W,Mohan M,Wang J

更新日期：2019-12-02 00:00:00

abstract：:The ter region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in Escherichia coli. Delayed segregation is controlled by the MatP protein, which binds to specific sites (matS) within ter, and interacts with other proteins such as ZapB. Here, we investigate t...

journal_title：Nature communications

authors： Crozat E,Tardin C,Salhi M,Rousseau P,Lablaine A,Bertoni T,Holcman D,Sclavi B,Cicuta P,Cornet F

更新日期：2020-07-30 00:00:00

abstract：:Controlled macrophage differentiation and activation in the initiation and resolution of inflammation is crucial for averting progression to chronic inflammatory and autoimmune diseases. Here we show a negative feedback mechanism for proinflammatory IFN-γ activation of macrophages driven by macrophage-associated matri...

journal_title：Nature communications

authors： Dufour A,Bellac CL,Eckhard U,Solis N,Klein T,Kappelhoff R,Fortelny N,Jobin P,Rozmus J,Mark J,Pavlidis P,Dive V,Barbour SJ,Overall CM

更新日期：2018-06-20 00:00:00

abstract：:VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may explain why they are not elicited by HIV-1 Env-immunization. Here we show that an optimized Env immu...

journal_title：Nature communications

authors： McGuire AT,Gray MD,Dosenovic P,Gitlin AD,Freund NT,Petersen J,Correnti C,Johnsen W,Kegel R,Stuart AB,Glenn J,Seaman MS,Schief WR,Strong RK,Nussenzweig MC,Stamatatos L

更新日期：2016-02-24 00:00:00

abstract：:The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Babakhanova G,Turiv T,Guo Y,Hendrikx M,Wei QH,Schenning APHJ,Broer DJ,Lavrentovich OD

更新日期：2018-03-14 00:00:00

abstract：:One of the fundamental design paradigms in organic photovoltaic device engineering is based on the idea that charge separation is an extrinsically driven process requiring an interface for exciton fission. This idea has driven an enormous materials science engineering effort focused on construction of domain sizes com...

journal_title：Nature communications

authors： Labastide JA,Thompson HB,Marques SR,Colella NS,Briseno AL,Barnes MD

更新日期：2016-02-25 00:00:00

abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...

journal_title：Nature communications

authors： Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

更新日期：2015-09-30 00:00:00

abstract：:Hearing relies on mechanical stimulation of stereocilia bundles on the sensory cells of the inner ear. When sound hits the ear, each stereocilium pivots about a neck-like taper near their base. More than three decades of research have established that sideways deflection of stereocilia is essential for converting mech...

journal_title：Nature communications

authors： Hakizimana P,Brownell WE,Jacob S,Fridberger A

更新日期：2012-01-01 00:00:00

abstract：:Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a po...

journal_title：Nature communications

authors： Sant'Anna R,Gallego P,Robinson LZ,Pereira-Henriques A,Ferreira N,Pinheiro F,Esperante S,Pallares I,Huertas O,Almeida MR,Reixach N,Insa R,Velazquez-Campoy A,Reverter D,Reig N,Ventura S

更新日期：2016-02-23 00:00:00

abstract：:Protein tyrosine O-sulfation (PTS) plays a crucial role in extracellular biomolecular interactions that dictate various cellular processes. It also involves in the development of many human diseases. Regardless of recent progress, our current understanding of PTS is still in its infancy. To promote and facilitate rele...

journal_title：Nature communications

authors： He X,Chen Y,Beltran DG,Kelly M,Ma B,Lawrie J,Wang F,Dodds E,Zhang L,Guo J,Niu W

更新日期：2020-09-24 00:00:00

abstract：:DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...

journal_title：Nature communications

authors： Adam S,Anteneh H,Hornisch M,Wagner V,Lu J,Radde NE,Bashtrykov P,Song J,Jeltsch A

更新日期：2020-07-24 00:00:00

abstract：:The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu-ZnO-ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in sit...

journal_title：Nature communications

authors： Wang Y,Kattel S,Gao W,Li K,Liu P,Chen JG,Wang H

更新日期：2019-03-11 00:00:00

abstract：:Samarium hexaboride is a classic three-dimensional mixed valence system with a high-temperature metallic phase that evolves into a paramagnetic charge insulator below 40 K. A number of recent experiments have suggested the possibility that the low-temperature insulating bulk hosts electrically neutral gapless fermioni...

journal_title：Nature communications

authors： Chowdhury D,Sodemann I,Senthil T

更新日期：2018-05-02 00:00:00

abstract：:Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...

journal_title：Nature communications

authors： Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ

更新日期：2018-08-22 00:00:00

abstract：:The future of coastal wetlands and their ecological value depend on their capacity to adapt to the interacting effects of human impacts and sea-level rise. Even though extensive wetland loss due to submergence is a possible scenario, its magnitude is highly uncertain due to limited understanding of hydrodynamic and bi...

journal_title：Nature communications

authors： Rodríguez JF,Saco PM,Sandi S,Saintilan N,Riccardi G

更新日期：2017-07-13 00:00:00

abstract：:Iron sequestration by host proteins contributes to the defence against bacterial pathogens, which need iron for their metabolism and virulence. A Pseudomonas aeruginosa mutant lacking all three known iron acquisition systems retains the ability to grow in media containing iron chelators, suggesting the presence of add...

journal_title：Nature communications

authors： Lin J,Zhang W,Cheng J,Yang X,Zhu K,Wang Y,Wei G,Qian PY,Luo ZQ,Shen X

更新日期：2017-03-28 00:00:00

abstract：:Activation of innate immunity by membrane-localized receptors is conserved across eukaryotes. Plant genomes contain hundreds of such receptor-like genes and those encoding proteins with an extracellular leucine-rich repeat (LRR) domain represent the largest family. Here, we develop a high-throughput approach to study ...

journal_title：Nature communications

authors： Wang Y,Xu Y,Sun Y,Wang H,Qi J,Wan B,Ye W,Lin Y,Shao Y,Dong S,Tyler BM,Wang Y

更新日期：2018-02-09 00:00:00

abstract：:Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit ...

journal_title：Nature communications

authors： Wang JY,Haider I,Jamil M,Fiorilli V,Saito Y,Mi J,Baz L,Kountche BA,Jia KP,Guo X,Balakrishna A,Ntui VO,Reinke B,Volpe V,Gojobori T,Blilou I,Lanfranco L,Bonfante P,Al-Babili S

更新日期：2019-02-18 00:00:00

abstract：:The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however the developmental stage at which CDX2 exerts its effect is unknown. We developed a conditionally inducible Cdx2 mouse model to deter...

journal_title：Nature communications

authors： Vu T,Straube J,Porter AH,Bywater M,Song A,Ling V,Cooper L,Pali G,Bruedigam C,Jacquelin S,Green J,Magor G,Perkins A,Chalk AM,Walkley CR,Heidel FH,Mukhopadhyay P,Cloonan N,Gröschel S,Mallm JP,Fröhling S,Scholl C,

更新日期：2020-06-15 00:00:00

abstract：:The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: 'A patent has been applied for by Emory University with F.E.L, I.S. and D.C. N. as named inventors. The patent application number is PCT/US2016/036650'. This has now been correct...

journal_title：Nature communications

authors： Nguyen DC,Garimalla S,Xiao H,Kyu S,Albizua I,Galipeau J,Chiang KY,Waller EK,Wu R,Gibson G,Roberson J,Lund FE,Randall TD,Sanz I,Lee FE

更新日期：2019-01-17 00:00:00

abstract：:Sepsis is a life-threatening condition triggered by a dysregulated host response to microbial infection resulting in vascular dysfunction, organ failure and death. Here we provide a semi-quantitative atlas of the murine vascular cell-surface proteome at the organ level, and how it changes during sepsis. Using in vivo ...

journal_title：Nature communications

authors： Toledo AG,Golden G,Campos AR,Cuello H,Sorrentino J,Lewis N,Varki N,Nizet V,Smith JW,Esko JD

更新日期：2019-10-11 00:00:00

abstract：:Dynamic changes in histone modifications under various physiological cues play important roles in gene transcription and cancer. Identification of new histone marks critical for cancer development is of particular importance. Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates his...

journal_title：Nature communications

authors： Zhang X,Li B,Rezaeian AH,Xu X,Chou PC,Jin G,Han F,Pan BS,Wang CY,Long J,Zhang A,Huang CY,Tsai FJ,Tsai CH,Logothetis C,Lin HK

更新日期：2017-03-16 00:00:00

abstract：:The direct transformation of cellulose, which is the main component of lignocellulosic biomass, into building-block chemicals is the key to establishing biomass-based sustainable chemical processes. Only limited successes have been achieved for such transformations under mild conditions. Here we report the simple and ...

journal_title：Nature communications

authors： Wang Y,Deng W,Wang B,Zhang Q,Wan X,Tang Z,Wang Y,Zhu C,Cao Z,Wang G,Wan H

更新日期：2013-01-01 00:00:00