DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation.

abstract：:The integration of nanophotonics and atomic physics has been a long-sought goal that would open new frontiers for optical physics, including novel quantum transport and many-body phenomena with photon-mediated atomic interactions. Reaching this goal requires surmounting diverse challenges in nanofabrication and atomic...

journal_title：Nature communications

authors： Goban A,Hung CL,Yu SP,Hood JD,Muniz JA,Lee JH,Martin MJ,McClung AC,Choi KS,Chang DE,Painter O,Kimble HJ

更新日期：2014-05-08 00:00:00

abstract：:Temporal cloaks have aroused tremendous research interest in both optical physics and optical communications, unfolding a distinct approach to conceal temporal events from an interrogating optical field. The state-of-the-art temporal cloaks exhibit picosecond-scale and static cloaking window, owing to significantly li...

journal_title：Nature communications

authors： Zhou F,Yan S,Zhou H,Wang X,Qiu H,Dong J,Zhou L,Ding Y,Qiu CW,Zhang X

更新日期：2019-06-20 00:00:00

abstract：:Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...

journal_title：Nature communications

authors： Qi H,Zhang H,Zhao Y,Chen C,Long JJ,Chung WK,Guan Y,Shen Y

更新日期：2021-01-21 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive analytical technique with molecular specificity, making it an ideal candidate for therapeutic drug monitoring (TDM). However, in critical diagnostic media including blood, nonspecific protein adsorption coupled with weak surface affinities and small Raman...

journal_title：Nature communications

authors： Sun F,Hung HC,Sinclair A,Zhang P,Bai T,Galvan DD,Jain P,Li B,Jiang S,Yu Q

更新日期：2016-11-11 00:00:00

abstract：:Large single-crystal graphene is highly desired and important for the applications of graphene in electronics, as grain boundaries between graphene grains markedly degrade its quality and properties. Here we report the growth of millimetre-sized hexagonal single-crystal graphene and graphene films joined from such gra...

journal_title：Nature communications

authors： Gao L,Ren W,Xu H,Jin L,Wang Z,Ma T,Ma LP,Zhang Z,Fu Q,Peng LM,Bao X,Cheng HM

更新日期：2012-02-28 00:00:00

abstract：:Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary s...

journal_title：Nature communications

authors： Pazoki R,Evangelou E,Mosen-Ansorena D,Pinto RC,Karaman I,Blakeley P,Gill D,Zuber V,Elliott P,Tzoulaki I,Dehghan A

更新日期：2019-08-13 00:00:00

abstract：:Several of the steps in protein synthesis on the ribosome utilize hydrolysis of guanosine triphosphate (GTP) as the driving force. This reaction is catalyzed by translation factors that become activated upon binding to the ribosome. The recently determined crystal structure of an elongation factor-Tu ternary complex b...

journal_title：Nature communications

authors： Wallin G,Kamerlin SC,Aqvist J

更新日期：2013-01-01 00:00:00

abstract：:Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design principles for bio...

journal_title：Nature communications

authors： D'Alessandro M,Beesley S,Kim JK,Chen R,Abich E,Cheng W,Yi P,Takahashi JS,Lee C

更新日期：2015-11-30 00:00:00

abstract：:Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators. Here, we apply unsupervised machine learning to a diverse compendium of over 250 ...

journal_title：Nature communications

authors： Sastry AV,Gao Y,Szubin R,Hefner Y,Xu S,Kim D,Choudhary KS,Yang L,King ZA,Palsson BO

更新日期：2019-12-04 00:00:00

abstract：:Neuroimaging evidence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and salience (SN) networks. Here we use human intracranial electroencephalography to investigate the behavioral relevance of fine-grained dynamics within and between these networks. The three n...

journal_title：Nature communications

authors： Kucyi A,Daitch A,Raccah O,Zhao B,Zhang C,Esterman M,Zeineh M,Halpern CH,Zhang K,Zhang J,Parvizi J

更新日期：2020-01-16 00:00:00

abstract：:Starting from the gas phase, small clusters can be produced and deposited with huge flexibility with regard to composition, materials choice and cluster size. Despite many advances in experimental characterization, a detailed morphology of such clusters is still lacking. Here we present an atomic scale observation as ...

journal_title：Nature communications

authors： Bals S,Van Aert S,Romero CP,Lauwaet K,Van Bael MJ,Schoeters B,Partoens B,Yücelen E,Lievens P,Van Tendeloo G

更新日期：2012-06-12 00:00:00

abstract：:The mesopelagic (200-1000 m) separates the productive upper ocean from the deep ocean, yet little is known of its long-term dynamics despite recent research that suggests fishes of this zone likely dominate global fish biomass and contribute to the downward flux of carbon. Here we show that mesopelagic fishes dominate...

journal_title：Nature communications

authors： Jones WA,Checkley DM Jr

更新日期：2019-10-08 00:00:00

abstract：:Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could benefit greatly from patient-specific targeted therapies that maximize treatment efficacy. Here we report a platform termed SynergySeq to identi...

journal_title：Nature communications

authors： Stathias V,Jermakowicz AM,Maloof ME,Forlin M,Walters W,Suter RK,Durante MA,Williams SL,Harbour JW,Volmar CH,Lyons NJ,Wahlestedt C,Graham RM,Ivan ME,Komotar RJ,Sarkaria JN,Subramanian A,Golub TR,Schürer SC,Ayad NG

更新日期：2018-12-14 00:00:00

abstract：:Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (ApcMin), or by Apc1322T encoding a partially-functional Apc truncation c...

journal_title：Nature communications

authors： Mieszczanek J,van Tienen LM,Ibrahim AEK,Winton DJ,Bienz M

更新日期：2019-02-13 00:00:00

abstract：:Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...

journal_title：Nature communications

authors： Tamura T,Williams GD,Fraser AD,Ohshima KI

更新日期：2012-05-08 00:00:00

abstract：:Understanding marine environmental change and associated biological turnover across the Palaeocene-Eocene Thermal Maximum (PETM; ~56 Ma)-the most pronounced Cenozoic short-term global warming event-is important because of the potential role of the ocean in atmospheric CO2 drawdown, yet proxies for tracing marine produ...

journal_title：Nature communications

authors： Chang L,Harrison RJ,Zeng F,Berndt TA,Roberts AP,Heslop D,Zhao X

更新日期：2018-10-01 00:00:00

abstract：:Single spins in the solid state offer a unique opportunity to store and manipulate quantum information, and to perform quantum-enhanced sensing of local fields and charges. Optical control of these systems using techniques developed in atomic physics has yet to exploit all the advantages of the solid state. Here we de...

journal_title：Nature communications

authors： Bennett AJ,Pooley MA,Cao Y,Sköld N,Farrer I,Ritchie DA,Shields AJ

更新日期：2013-01-01 00:00:00

abstract：:The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit criti...

journal_title：Nature communications

authors： Maturana MI,Meisel C,Dell K,Karoly PJ,D'Souza W,Grayden DB,Burkitt AN,Jiruska P,Kudlacek J,Hlinka J,Cook MJ,Kuhlmann L,Freestone DR

更新日期：2020-05-01 00:00:00

abstract：:Chemical synthesis of amino acids from renewable sources is an alternative route to the current processes based on fermentation. Here, we report visible-light-driven amination of biomass-derived α-hydroxyl acids and glucose into amino acids using NH3 at 50 °C. Ultrathin CdS nanosheets are identified as an efficient an...

journal_title：Nature communications

authors： Song S,Qu J,Han P,Hülsey MJ,Zhang G,Wang Y,Wang S,Chen D,Lu J,Yan N

更新日期：2020-09-29 00:00:00

abstract：:Biodiversity-ecosystem functioning (BEF) experiments have shown that local species richness promotes ecosystem functioning and stability. Whether this also applies under real-world conditions is still debated. Here, we focus on larger scales of space, time and ecological organization. We develop a quasi-experimental d...

journal_title：Nature communications

authors： Oehri J,Schmid B,Schaepman-Strub G,Niklaus PA

更新日期：2020-01-09 00:00:00

abstract：:The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important components of the metastatic tumor microenvironment and exhibit heterogeneity. However, the specific phenotypes, funct...

journal_title：Nature communications

authors： Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG

更新日期：2021-01-08 00:00:00

abstract：:For COVID-19, it is vital to understand if quarantines shorter than 14 days can be equally effective with judiciously deployed testing. Here, we develop a mathematical model that quantifies the probability of post-quarantine transmission incorporating testing into travel quarantine, quarantine of traced contacts with ...

journal_title：Nature communications

authors： Wells CR,Townsend JP,Pandey A,Moghadas SM,Krieger G,Singer B,McDonald RH,Fitzpatrick MC,Galvani AP

更新日期：2021-01-07 00:00:00

abstract：:PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a novel PETase from the PET-consuming microbe Ideonella sakaiensis in complex with substrate and product analogs. Th...

journal_title：Nature communications

authors： Han X,Liu W,Huang JW,Ma J,Zheng Y,Ko TP,Xu L,Cheng YS,Chen CC,Guo RT

更新日期：2017-12-13 00:00:00

abstract：:The isolation of the two-dimensional semiconductor molybdenum disulphide introduced a new optically active material possessing a band gap that can be facilely tuned via elastic strain. As an atomically thin membrane with exceptional strength, monolayer molybdenum disulphide subjected to biaxial strain can embed wide b...

journal_title：Nature communications

authors： Li H,Contryman AW,Qian X,Ardakani SM,Gong Y,Wang X,Weisse JM,Lee CH,Zhao J,Ajayan PM,Li J,Manoharan HC,Zheng X

更新日期：2015-06-19 00:00:00

abstract：:The presence of a di-unsaturated highly branched isoprenoid (HBI) lipid biomarker (diene II) in Southern Ocean sediments has previously been proposed as a proxy measure of palaeo Antarctic sea ice. Here we show that a source of diene II is the sympagic diatom Berkeleya adeliensis Medlin. Furthermore, the propensity fo...

journal_title：Nature communications

authors： Belt ST,Smik L,Brown TA,Kim JH,Rowland SJ,Allen CS,Gal JK,Shin KH,Lee JI,Taylor KW

更新日期：2016-08-30 00:00:00

abstract：:Accurately predicting chromatin loops from genome-wide interaction matrices such as Hi-C data is critical to deepening our understanding of proper gene regulation. Current approaches are mainly focused on searching for statistically enriched dots on a genome-wide map. However, given the availability of orthogonal data...

journal_title：Nature communications

authors： Salameh TJ,Wang X,Song F,Zhang B,Wright SM,Khunsriraksakul C,Ruan Y,Yue F

更新日期：2020-07-09 00:00:00

abstract：:Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...

journal_title：Nature communications

authors： Kehayias P,Jarmola A,Mosavian N,Fescenko I,Benito FM,Laraoui A,Smits J,Bougas L,Budker D,Neumann A,Brueck SRJ,Acosta VM

更新日期：2017-08-04 00:00:00

abstract：:Astrocytes migrate from the optic nerve into the inner retina, forming a template upon which retinal vessels develop. In the Nuc1 rat, mutation in the gene encoding βA3/A1-crystallin disrupts both Notch signalling in astrocytes and formation of the astrocyte template. Here we show that loss of βA3/A1-crystallin in ast...

journal_title：Nature communications

authors： Valapala M,Hose S,Gongora C,Dong L,Wawrousek EF,Samuel Zigler J Jr,Sinha D

更新日期：2013-01-01 00:00:00

abstract：:Large igneous province subduction is a rare process on Earth. A modern example is the subduction of the oceanic Hikurangi Plateau beneath the southern Kermadec arc, offshore New Zealand. This segment of the arc has the largest total lava volume erupted and the highest volcano density of the entire Kermadec arc. Here w...

journal_title：Nature communications

authors： Timm C,Davy B,Haase K,Hoernle KA,Graham IJ,de Ronde CE,Woodhead J,Bassett D,Hauff F,Mortimer N,Seebeck HC,Wysoczanski RJ,Caratori-Tontini F,Gamble JA

更新日期：2014-09-17 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity-a measure ...

journal_title：Nature communications

authors： Keshelava A,Solis GP,Hersch M,Koval A,Kryuchkov M,Bergmann S,Katanaev VL

更新日期：2018-02-28 00:00:00