Abstract:
:The vimentin network displays remarkable plasticity to support basic cellular functions and reorganizes during cell division. Here, we show that in several cell types vimentin filaments redistribute to the cell cortex during mitosis, forming a robust framework interwoven with cortical actin and affecting its organization. Importantly, the intrinsically disordered tail domain of vimentin is essential for this redistribution, which allows normal mitotic progression. A tailless vimentin mutant forms curly bundles, which remain entangled with dividing chromosomes leading to mitotic catastrophes or asymmetric partitions. Serial deletions of vimentin tail domain gradually impair cortical association and mitosis progression. Disruption of f-actin, but not of microtubules, causes vimentin bundling near the chromosomes. Pathophysiological stimuli, including HIV-protease and lipoxidation, induce similar alterations. Interestingly, full filament formation is dispensable for cortical association, which also occurs in vimentin particles. These results unveil implications of vimentin dynamics in cell division through its interplay with the actin cortex.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Duarte S,Viedma-Poyatos Á,Navarro-Carrasco E,Martínez AE,Pajares MA,Pérez-Sala Ddoi
10.1038/s41467-019-12029-4subject
Has Abstractpub_date
2019-09-13 00:00:00pages
4200issue
1issn
2041-1723pii
10.1038/s41467-019-12029-4journal_volume
10pub_type
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