Abstract:
:Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain unclear. Here we demonstrate 6mA dynamics in the mouse brain in response to environmental stress. We find that overall 6mA levels are significantly elevated upon stress. Genome-wide 6mA and transcriptome profiling reveal an inverse association between 6mA dynamic changes and a set of upregulated neuronal genes or downregulated LINE transposon expression. Genes bearing stress-induced 6mA changes significantly overlap with loci associated with neuropsychiatric disorders. These results suggest an epigenetic role for 6mA in the mammalian brain as well as its potential involvement in neuropsychiatric disorders.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yao B,Cheng Y,Wang Z,Li Y,Chen L,Huang L,Zhang W,Chen D,Wu H,Tang B,Jin Pdoi
10.1038/s41467-017-01195-ysubject
Has Abstractpub_date
2017-10-24 00:00:00pages
1122issue
1issn
2041-1723pii
10.1038/s41467-017-01195-yjournal_volume
8pub_type
杂志文章abstract:: ...
journal_title:Nature communications
pub_type: 社论
doi:10.1038/s41467-018-07733-6
更新日期:2018-12-10 00:00:00
abstract::Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10241
更新日期:2016-01-08 00:00:00
abstract::Quintulene, a non-graphitic cycloarene with fivefold symmetry, has remained synthetically elusive due to its high molecular strain originating from its curved structure. Here we report the construction of extended quintulene, which was unambiguously characterized by mass and NMR spectroscopy. The extended quintulene r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17691-7
更新日期:2020-08-07 00:00:00
abstract::The 2018 summit and flank eruption of Kīlauea Volcano was one of the largest volcanic events in Hawai'i in 200 years. Data suggest that a backup in the magma plumbing system at the long-lived Pu'u 'Ō'ō eruption site caused widespread pressurization in the volcano, driving magma into the lower flank. The eruption evolv...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-19190-1
更新日期:2020-11-06 00:00:00
abstract::Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14200-3
更新日期:2020-01-23 00:00:00
abstract::Hybrid quantum systems are essential for the realization of distributed quantum networks. In particular, piezo-mechanics operating at typical superconducting qubit frequencies features low thermal excitations, and offers an appealing platform to bridge superconducting quantum processors and optical telecommunication c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17053-3
更新日期:2020-06-26 00:00:00
abstract::A diversity of self-propelled chemical motors, based on Marangoni propulsive forces, has been developed in recent years. However, most motors are non-functional due to poor performance, a lack of control, and the use of toxic materials. To overcome these limitations, we have developed multifunctional and biodegradable...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11141-9
更新日期:2019-07-18 00:00:00
abstract::Chains of quantum dots coupled to superconductors are promising for the realization of the Kitaev model of a topological superconductor. While individual superconducting quantum dots have been explored, control of longer chains requires understanding of interdot coupling. Here, double quantum dots are defined by gate ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00665-7
更新日期:2017-09-19 00:00:00
abstract::Chirality and liquid crystals are both widely expressed in nature and biology. Helical assembly of mesophasic molecules and colloids may produce intriguing chiral liquid crystals. To date, chiral liquid crystals of 2D colloids have not been explored. As a typical 2D colloid, graphene is now receiving unprecedented att...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1583
更新日期:2011-12-06 00:00:00
abstract::The dominant dipolar component of the Earth's magnetic field has been steadily weakening for at least the last 170 years. Prior to these direct measurements, archaeomagnetic records show short periods of significantly elevated geomagnetic intensity. These striking phenomena are not captured by current field models and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3727
更新日期:2013-01-01 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms15317. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms16128
更新日期:2017-06-30 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11151-7
更新日期:2019-07-22 00:00:00
abstract::Bipolaron states, in which two electrons or two holes occupy a single molecule or conjugated polymer segment, are typically considered to be negligible in organic semiconductor devices due to Coulomb repulsion between the two charges. Here we use charge modulation spectroscopy to reveal a bipolaron sheet density >1010...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02459-3
更新日期:2017-12-21 00:00:00
abstract::The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N's function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of MavC in complex wi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16587-w
更新日期:2020-06-02 00:00:00
abstract::Grain boundaries have a major effect on the physical properties of two-dimensional layered materials. Therefore, it is important to develop simple, fast and sensitive characterization methods to visualize grain boundaries. Conventional Raman and photoluminescence methods have been used for detecting grain boundaries; ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15714
更新日期:2017-06-05 00:00:00
abstract::Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Despite the initial efficacy of taxanes in treating CRPC, all patients ultimately fail due to the development of drug resistance. In this study, we show that ERG overexpression in in vitro and in viv...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6548
更新日期:2014-11-25 00:00:00
abstract::The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with ABCC4 in AML, is associated with worse overall su...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01678-y
更新日期:2017-11-16 00:00:00
abstract::In all known examples of metal-ligand (M-L) δ and φ bonds, the metal orbitals are aligned to the ligand orbitals in a "head-to-head" or "side-to-head" fashion. Here, we report two fundamentally new types of M-L δ and φ interactions; "head-to-side" δ and "side-to-side" φ back-bonding, found in complexes of metallacyclo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15197-w
更新日期:2020-03-25 00:00:00
abstract::Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk. We explore the relationship between lipid and glucose control by con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20750-8
更新日期:2021-01-22 00:00:00
abstract::Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4224
更新日期:2014-01-01 00:00:00
abstract::Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent prop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1612
更新日期:2012-01-03 00:00:00
abstract::Soil bacterial diversity varies across biomes with potential impacts on soil ecological functioning. Here, we incorporate key factors that affect soil bacterial abundance and diversity across spatial scales into a mechanistic modeling framework considering soil type, carbon inputs and climate towards predicting soil b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13966-w
更新日期:2020-01-08 00:00:00
abstract::The dynamics of many natural and artificial systems are well described as random walks on a network: the stochastic behaviour of molecules, traffic patterns on the internet, fluctuations in stock prices and so on. The vast literature on random walks provides many tools for computing properties such as steady-state pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6121
更新日期:2014-10-14 00:00:00
abstract::We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15363-0
更新日期:2020-03-27 00:00:00
abstract::Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08620-4
更新日期:2019-05-21 00:00:00
abstract::Quantum computers promise to solve certain problems more efficiently than their digital counterparts. A major challenge towards practically useful quantum computing is characterizing and reducing the various errors that accumulate during an algorithm running on large-scale processors. Current characterization techniqu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13068-7
更新日期:2019-11-25 00:00:00
abstract::Methanol is a biotechnologically promising substitute for food and feed substrates since it can be produced renewably from electricity, water and CO2. Although progress has been made towards establishing Escherichia coli as a platform organism for methanol conversion via the energy efficient ribulose monophosphate (Ru...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19235-5
更新日期:2020-10-26 00:00:00
abstract::Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12667
更新日期:2016-10-11 00:00:00
abstract::The electronic properties of graphene are described by a Dirac Hamiltonian with a four-fold symmetry of spin and valley. This symmetry may yield novel fractional quantum Hall (FQH) states at high magnetic field depending on the relative strength of symmetry-breaking interactions. However, observing such states in tran...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6838
更新日期:2015-01-06 00:00:00
abstract::Oxygen vacancies in proximity to surfaces and heterointerfaces in oxide thin film heterostructures have major effects on properties, resulting, for example, in emergent conduction behaviour, large changes in metal-insulator transition temperatures or enhanced catalytic activity. Here we report the discovery of a means...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11892
更新日期:2016-06-10 00:00:00