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Protein-targeted corona phase molecular recognition.

Abstract：

:Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated by the quenching kinetics. The fibrinogen recognition also occurs in serum environment, at the clinically relevant fibrinogen concentrations in the human blood. These results open new avenues for synthetic, non-biological antibody analogues that recognize biological macromolecules, and hold great promise for medical and clinical applications.

journal_name

Nat Commun

journal_title

Nature communications

authors

Bisker G,Dong J,Park HD,Iverson NM,Ahn J,Nelson JT,Landry MP,Kruss S,Strano MS

doi

10.1038/ncomms10241

subject

Has Abstract

pub_date

2016-01-08 00:00:00

pages

10241

issn

2041-1723

pii

ncomms10241

journal_volume

7

pub_type

杂志文章

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