Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Abstract:

:Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find that intratumoral therapy with Newcastle disease virus (NDV), in addition to the activation of innate immunity, upregulates the expression of T-cell co-stimulatory receptors, with the inducible co-stimulator (ICOS) being most notable. To explore ICOS as a direct target in the tumour, we engineered a recombinant NDV-expressing ICOS ligand (NDV-ICOSL). In the bilateral flank tumour models, intratumoral administration of NDV-ICOSL results in enhanced infiltration with activated T cells in both virus-injected and distant tumours, and leads to effective rejection of both tumours when used in combination with systemic CTLA-4 blockade. These findings highlight that intratumoral immunomodulation with an oncolytic virus expressing a rationally selected ligand can be an effective strategy to drive systemic efficacy of immune checkpoint blockade.

journal_name

Nat Commun

journal_title

Nature communications

authors

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

doi

10.1038/ncomms14340

subject

Has Abstract

pub_date

2017-02-13 00:00:00

pages

14340

issn

2041-1723

pii

ncomms14340

journal_volume

8

pub_type

杂志文章
  • The unlikely Carnot efficiency.

    abstract::The efficiency of an heat engine is traditionally defined as the ratio of its average output work over its average input heat. Its highest possible value was discovered by Carnot in 1824 and is a cornerstone concept in thermodynamics. It led to the discovery of the second law and to the definition of the Kelvin temper...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5721

    authors: Verley G,Esposito M,Willaert T,Van den Broeck C

    更新日期:2014-09-15 00:00:00

  • STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.

    abstract::A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while impacting only on cycling cell subsets. Here, we show that a proapoptotic secretory phenotype is induced by activation of cGAS/STING in can...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13689-y

    authors: Lohard S,Bourgeois N,Maillet L,Gautier F,Fétiveau A,Lasla H,Nguyen F,Vuillier C,Dumont A,Moreau-Aubry A,Frapin M,David L,Loussouarn D,Kerdraon O,Campone M,Jézéquel P,Juin PP,Barillé-Nion S

    更新日期:2020-01-14 00:00:00

  • Origin of the unusually strong and selective binding of vanadium by polyamidoximes in seawater.

    abstract::Amidoxime-functionalized polymeric adsorbents are the current state-of-the-art materials for collecting uranium (U) from seawater. However, marine tests show that vanadium (V) is preferentially extracted over U and many other cations. Herein, we report a complementary and comprehensive investigation integrating ab ini...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-01443-1

    authors: Ivanov AS,Leggett CJ,Parker BF,Zhang Z,Arnold J,Dai S,Abney CW,Bryantsev VS,Rao L

    更新日期:2017-11-16 00:00:00

  • Licensing MLH1 sites for crossover during meiosis.

    abstract::During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related homoeologues. Here we report that--in wheat-rye hybrids where homologue...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5580

    authors: Martín AC,Shaw P,Phillips D,Reader S,Moore G

    更新日期:2014-08-06 00:00:00

  • A metallic molybdenum dioxide with high stability for surface enhanced Raman spectroscopy.

    abstract::Compared with noble metals, semiconductors with surface plasmon resonance effect are another type of SERS substrate materials. The main obstacles so far are that the semiconducting materials are often unstable and easy to be further oxidized or decomposed by laser irradiating or contacting with corrosive substances. H...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14903

    authors: Zhang Q,Li X,Ma Q,Zhang Q,Bai H,Yi W,Liu J,Han J,Xi G

    更新日期:2017-04-24 00:00:00

  • Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation.

    abstract::CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6909

    authors: Wang L,Liu R,Ye P,Wong C,Chen GY,Zhou P,Sakabe K,Zheng X,Wu W,Zhang P,Jiang T,Bassetti MF,Jube S,Sun Y,Zhang Y,Zheng P,Liu Y

    更新日期:2015-01-20 00:00:00

  • Sequence-regulated vinyl copolymers by metal-catalysed step-growth radical polymerization.

    abstract::Proteins and nucleic acids are sequence-regulated macromolecules with various properties originating from their perfectly sequenced primary structures. However, the sequence regulation of synthetic polymers, particularly vinyl polymers, has not been achieved and is one of the ultimate goals in polymer chemistry. In th...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1004

    authors: Satoh K,Ozawa S,Mizutani M,Nagai K,Kamigaito M

    更新日期:2010-04-12 00:00:00

  • Ribosome profiling reveals features of normal and disease-associated mitochondrial translation.

    abstract::Mitochondria are essential cellular organelles for generation of energy and their dysfunction may cause diabetes, Parkinson's disease and multi-systemic failure marked by failure to thrive, gastrointestinal problems, lactic acidosis and early lethality. Disease-associated mitochondrial mutations often affect component...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3886

    authors: Rooijers K,Loayza-Puch F,Nijtmans LG,Agami R

    更新日期:2013-01-01 00:00:00

  • Demographic routes to variability and regulation in bird populations.

    abstract::There is large interspecific variation in the magnitude of population fluctuations, even among closely related species. The factors generating this variation are not well understood, primarily because of the challenges of separating the relative impact of variation in population size from fluctuations in the environme...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12001

    authors: Sæther BE,Grøtan V,Engen S,Coulson T,Grant PR,Visser ME,Brommer JE,Rosemary Grant B,Gustafsson L,Hatchwell BJ,Jerstad K,Karell P,Pietiäinen H,Roulin A,Røstad OW,Weimerskirch H

    更新日期:2016-06-22 00:00:00

  • Author Correction: Response outcomes gate the impact of expectations on perceptual decisions.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41467-020-17071-1

    authors: Hermoso-Mendizabal A,Hyafil A,Rueda-Orozco PE,Jaramillo S,Robbe D,de la Rocha J

    更新日期:2020-07-07 00:00:00

  • Controlling spin current polarization through non-collinear antiferromagnetism.

    abstract::The interconversion of charge and spin currents via spin-Hall effect is essential for spintronics. Energy-efficient and deterministic switching of magnetization can be achieved when spin polarizations of these spin currents are collinear with the magnetization. However, symmetry conditions generally restrict spin pola...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-17999-4

    authors: Nan T,Quintela CX,Irwin J,Gurung G,Shao DF,Gibbons J,Campbell N,Song K,Choi S-,Guo L,Johnson RD,Manuel P,Chopdekar RV,Hallsteinsen I,Tybell T,Ryan PJ,Kim J-,Choi Y,Radaelli PG,Ralph DC,Tsymbal EY,Rzchowski MS,

    更新日期:2020-09-16 00:00:00

  • The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.

    abstract::Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3112

    authors: Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K

    更新日期:2013-01-01 00:00:00

  • Extraordinary momentum and spin in evanescent waves.

    abstract::Momentum and spin represent fundamental dynamic properties of quantum particles and fields. In particular, propagating optical waves (photons) carry momentum and longitudinal spin determined by the wave vector and circular polarization, respectively. Here we show that exactly the opposite can be the case for evanescen...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4300

    authors: Bliokh KY,Bekshaev AY,Nori F

    更新日期:2014-03-06 00:00:00

  • Reversing the charge transfer between platinum and sulfur-doped carbon support for electrocatalytic hydrogen evolution.

    abstract::Metal-support interaction is of great significance for catalysis as it can induce charge transfer between metal and support, tame electronic structure of supported metals, impact adsorption energy of reaction intermediates, and eventually change the catalytic performance. Here, we report the metal size-dependent charg...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-12851-w

    authors: Yan QQ,Wu DX,Chu SQ,Chen ZQ,Lin Y,Chen MX,Zhang J,Wu XJ,Liang HW

    更新日期:2019-10-31 00:00:00

  • Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

    abstract::Ubiquitin-specific protease 14 (USP14) is one of the major proteasome-associated deubiquitinating enzymes critical for proteome homeostasis. However, substrates of USP14 remain largely unknown, hindering the understanding of its functional roles. Here we conduct a comprehensive proteome, ubiquitinome and interactome a...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07185-y

    authors: Liu B,Jiang S,Li M,Xiong X,Zhu M,Li D,Zhao L,Qian L,Zhai L,Li J,Lu H,Sun S,Lin J,Lu Y,Li X,Tan M

    更新日期:2018-11-13 00:00:00

  • Energy-loss return gate via liquid dielectric polarization.

    abstract::There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03893-7

    authors: Kim T,Yong H,Kim B,Kim D,Choi D,Park YT,Lee S

    更新日期:2018-04-12 00:00:00

  • Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.

    abstract::Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylatio...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms8679

    authors: Zhou Y,Yamada N,Tanaka T,Hori T,Yokoyama S,Hayakawa Y,Yano S,Fukuoka J,Koizumi K,Saiki I,Sakurai H

    更新日期:2015-07-09 00:00:00

  • Observations of pressure anisotropy effects within semi-collisional magnetized plasma bubbles.

    abstract::Magnetized plasma interactions are ubiquitous in astrophysical and laboratory plasmas. Various physical effects have been shown to be important within colliding plasma flows influenced by opposing magnetic fields, however, experimental verification of the mechanisms within the interaction region has remained elusive. ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20387-7

    authors: Tubman ER,Joglekar AS,Bott AFA,Borghesi M,Coleman B,Cooper G,Danson CN,Durey P,Foster JM,Graham P,Gregori G,Gumbrell ET,Hill MP,Hodge T,Kar S,Kingham RJ,Read M,Ridgers CP,Skidmore J,Spindloe C,Thomas AGR,Treadwe

    更新日期:2021-01-12 00:00:00

  • Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics.

    abstract::Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18718-9

    authors: Kato A,Adachi S,Kawano S,Takeshima K,Watanabe M,Kitazume S,Sato R,Kusano H,Koyanagi N,Maruzuru Y,Arii J,Hatta T,Natsume T,Kawaguchi Y

    更新日期:2020-09-29 00:00:00

  • Non-invasive assessment of telomere maintenance mechanisms in brain tumors.

    abstract::Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere maintenance while astrocytomas use the alternative lengthening of telomeres (ALT) pathway. Although TERT and ALT are hallmarks of tumor prolifer...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20312-y

    authors: Viswanath P,Batsios G,Mukherjee J,Gillespie AM,Larson PEZ,Luchman HA,Phillips JJ,Costello JF,Pieper RO,Ronen SM

    更新日期:2021-01-04 00:00:00

  • Fast response of cold ice-rich permafrost in northeast Siberia to a warming climate.

    abstract::The ice- and organic-rich permafrost of the northeast Siberian Arctic lowlands (NESAL) has been projected to remain stable beyond 2100, even under pessimistic climate warming scenarios. However, the numerical models used for these projections lack processes which induce widespread landscape change termed thermokarst, ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-15725-8

    authors: Nitzbon J,Westermann S,Langer M,Martin LCP,Strauss J,Laboor S,Boike J

    更新日期:2020-05-04 00:00:00

  • Evolution and structure of clinically relevant gene fusions in multiple myeloma.

    abstract::Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect gene fusions from a cohort of 742 patients from the Multiple Myeloma Research Foundation CoMMpass Study. Patients with multiple clinic visits ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16434-y

    authors: Foltz SM,Gao Q,Yoon CJ,Sun H,Yao L,Li Y,Jayasinghe RG,Cao S,King J,Kohnen DR,Fiala MA,Ding L,Vij R

    更新日期:2020-05-29 00:00:00

  • Transcriptional read-through of the long non-coding RNA SVALKA governs plant cold acclimation.

    abstract::Most DNA in the genomes of higher organisms does not encode proteins, yet much is transcribed by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The biological significance of most lncRNAs is largely unclear. Here, we identify a lncRNA (SVALKA) in a cold-sensitive region of the Arabidopsis genome. Muta...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07010-6

    authors: Kindgren P,Ard R,Ivanov M,Marquardt S

    更新日期:2018-11-01 00:00:00

  • Single-pass transformation of syngas into ethanol with high selectivity by triple tandem catalysis.

    abstract::Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14672-8

    authors: Kang J,He S,Zhou W,Shen Z,Li Y,Chen M,Zhang Q,Wang Y

    更新日期:2020-02-11 00:00:00

  • An enrichment method based on synergistic and reversible covalent interactions for large-scale analysis of glycoproteins.

    abstract::Protein glycosylation is ubiquitous in biological systems and essential for cell survival. However, the heterogeneity of glycans and the low abundance of many glycoproteins complicate their global analysis. Chemical methods based on reversible covalent interactions between boronic acid and glycans have great potential...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04081-3

    authors: Xiao H,Chen W,Smeekens JM,Wu R

    更新日期:2018-04-27 00:00:00

  • Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct.

    abstract::Notwithstanding the central biological role of the (6-4) photoadduct in the induction of skin cancer by sunlight, crucial mechanistic details about its formation have evaded characterization despite efforts spanning more than half a century. 4-Thiothymidine (4tT) has been widely used as an important model system to st...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-17333-y

    authors: Ortiz-Rodríguez LA,Reichardt C,Hoehn SJ,Jockusch S,Crespo-Hernández CE

    更新日期:2020-07-17 00:00:00

  • Ferroelectric tunnel junctions with graphene electrodes.

    abstract::Polarization-driven resistive switching in ferroelectric tunnel junctions (FTJs)--structures composed of two electrodes separated by an ultrathin ferroelectric barrier--offers new physics and materials functionalities, as well as exciting opportunities for the next generation of non-volatile memories and logic devices...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6518

    authors: Lu H,Lipatov A,Ryu S,Kim DJ,Lee H,Zhuravlev MY,Eom CB,Tsymbal EY,Sinitskii A,Gruverman A

    更新日期:2014-11-24 00:00:00

  • LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate.

    abstract::Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer transcription factors have prominent roles in this process because of their ability to contact their cognate binding motifs in closed chromatin. Reprogramming is pervasive in plants, whose development is plastic and tuned by the envi...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20883-w

    authors: Jin R,Klasfeld S,Zhu Y,Fernandez Garcia M,Xiao J,Han SK,Konkol A,Wagner D

    更新日期:2021-01-27 00:00:00

  • RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.

    abstract::MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases of viral infection...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19318-3

    authors: Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B

    更新日期:2020-11-02 00:00:00

  • Persistent super-diffusive motion of Escherichia coli chromosomal loci.

    abstract::The physical nature of the bacterial chromosome has important implications for its function. Using high-resolution dynamic tracking, we observe the existence of rare but ubiquitous 'rapid movements' of chromosomal loci exhibiting near-ballistic dynamics. This suggests that these movements are either driven by an activ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4854

    authors: Javer A,Kuwada NJ,Long Z,Benza VG,Dorfman KD,Wiggins PA,Cicuta P,Lagomarsino MC

    更新日期:2014-05-30 00:00:00