Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling.

abstract：:Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initiall...

journal_title：Nature communications

authors： Maurice NJ,McElrath MJ,Andersen-Nissen E,Frahm N,Prlic M

更新日期：2019-11-01 00:00:00

abstract：:The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and m...

journal_title：Nature communications

authors： Ding J,Chen K,Liu H,Huang L,Chen Y,Lv Y,Yang Q,Guo Q,Han Z,Lambon Ralph MA

更新日期：2020-05-22 00:00:00

abstract：:Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ioni...

journal_title：Nature communications

authors： Corde S,Adli E,Allen JM,An W,Clarke CI,Clausse B,Clayton CE,Delahaye JP,Frederico J,Gessner S,Green SZ,Hogan MJ,Joshi C,Litos M,Lu W,Marsh KA,Mori WB,Vafaei-Najafabadi N,Walz D,Yakimenko V

更新日期：2016-06-17 00:00:00

abstract：:Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis. We hence conducted a randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patie...

journal_title：Nature communications

authors： Zhang Y,Gu Y,Ren H,Wang S,Zhong H,Zhao X,Ma J,Gu X,Xue Y,Huang S,Yang J,Chen L,Chen G,Qu S,Liang J,Qin L,Huang Q,Peng Y,Li Q,Wang X,Kong P,Hou G,Gao M,Shi Z,Li X,Qiu Y,Zou Y,Yang H,Wang J,Xu G,

更新日期：2020-10-06 00:00:00

abstract：:Domain walls can be driven by current at very high speeds in nanowires formed from ultra-thin, perpendicularly magnetized cobalt layers and cobalt/nickel multilayers deposited on platinum underlayers due to a chiral spin torque. An important feature of this torque is a magnetic chiral exchange field that each domain w...

journal_title：Nature communications

authors： Ryu KS,Yang SH,Thomas L,Parkin SS

更新日期：2014-05-23 00:00:00

abstract：:Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) are implicated in cell trafficking. We discovered that the expression of ECM epidermal growth factor-like protein 7 (EGFL7) is increased in the CNS vasculature of patients with multiple sclerosis (MS), and in mice with ex...

journal_title：Nature communications

authors： Larochelle C,Uphaus T,Broux B,Gowing E,Paterka M,Michel L,Dudvarski Stankovic N,Bicker F,Lemaître F,Prat A,Schmidt MHH,Zipp F

更新日期：2018-02-26 00:00:00

abstract：:Environmental metabolomes are fundamentally coupled to microbially-linked biogeochemical processes within ecosystems. However, significant gaps exist in our understanding of their spatiotemporal organization, limiting our ability to uncover transferrable principles and predict ecosystem function. We propose that a the...

journal_title：Nature communications

authors： Danczak RE,Chu RK,Fansler SJ,Goldman AE,Graham EB,Tfaily MM,Toyoda J,Stegen JC

更新日期：2020-12-11 00:00:00

abstract：:Human-machine interfaces have benefited from the advent of wireless sensor networks and the internet of things, but rely on wearable/attachable electronics exhibiting stretchability, biocompatibility, and transmittance. Limited by weight and volume, wearable devices should be energy efficient and even self-powered. He...

journal_title：Nature communications

authors： Lee Y,Cha SH,Kim YW,Choi D,Sun JY

更新日期：2018-05-04 00:00:00

abstract：:The concept of spin-torque-driven high-frequency magnetization dynamics, allows the potential construction of complex networks of non-linear dynamical nanoscale systems, combining the field of spintronics and the study of non-linear systems. In the few previous demonstrations of synchronization of several spin-torque ...

journal_title：Nature communications

authors： Lebrun R,Tsunegi S,Bortolotti P,Kubota H,Jenkins AS,Romera M,Yakushiji K,Fukushima A,Grollier J,Yuasa S,Cros V

更新日期：2017-06-12 00:00:00

abstract：:Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here w...

journal_title：Nature communications

authors： Martos-Maldonado MC,Hjuler CT,Sørensen KK,Thygesen MB,Rasmussen JE,Villadsen K,Midtgaard SR,Kol S,Schoffelen S,Jensen KJ

更新日期：2018-08-17 00:00:00

abstract：:A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability an...

journal_title：Nature communications

authors： Guiziou S,Mayonove P,Bonnet J

更新日期：2019-01-28 00:00:00

abstract：:Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposo...

journal_title：Nature communications

authors： Shen J,Liu J,Xie K,Xing F,Xiong F,Xiao J,Li X,Xiong L

更新日期：2017-03-03 00:00:00

abstract：:Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of ...

journal_title：Nature communications

authors： Chacón-Duque JC,Adhikari K,Fuentes-Guajardo M,Mendoza-Revilla J,Acuña-Alonzo V,Barquera R,Quinto-Sánchez M,Gómez-Valdés J,Everardo Martínez P,Villamil-Ramírez H,Hünemeier T,Ramallo V,Silva de Cerqueira CC,Hurtado M,Villegas V

更新日期：2018-12-19 00:00:00

abstract：:The three-dimensional structure of chromosomes plays an important role in gene expression regulation and also influences the repair of radiation-induced DNA damage. Genomic aberrations that disrupt chromosome spatial domains can lead to diseases including cancer, but how the 3D genome structure responds to DNA damage ...

journal_title：Nature communications

authors： Sanders JT,Freeman TF,Xu Y,Golloshi R,Stallard MA,Hill AM,San Martin R,Balajee AS,McCord RP

更新日期：2020-12-02 00:00:00

abstract：:Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs signaling is reported to enhance fa...

journal_title：Nature communications

authors： Xu H,Zhao Q,Song N,Yan Z,Lin R,Wu S,Jiang L,Hong S,Xie J,Zhou H,Wang R,Jiang X

更新日期：2020-11-16 00:00:00

abstract：:Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully recode, construct and characterize the biosynthetic pathway of bikaverin, a tetracyclic polyketide with antib...

journal_title：Nature communications

authors： Zhao M,Zhao Y,Yao M,Iqbal H,Hu Q,Liu H,Qiao B,Li C,Skovbjerg CAS,Nielsen JC,Nielsen J,Frandsen RJN,Yuan Y,Boeke JD

更新日期：2020-12-03 00:00:00

abstract：:Alkali metal vapors enable access to single electron systems, suitable for demonstrating fundamental light-matter interactions and promising for quantum logic operations, storage and sensing. However, progress is hampered by the need for robust and repeatable control over the atomic vapor density and over the associat...

journal_title：Nature communications

authors： Rusimova KR,Slavov D,Pradaux-Caggiano F,Collins JT,Gordeev SN,Carbery DR,Wadsworth WJ,Mosley PJ,Valev VK

更新日期：2019-05-24 00:00:00

abstract：:The discovery of superconductivity at 260 K in hydrogen-rich compounds like LaH10 re-invigorated the quest for room temperature superconductivity. Here, we report the temperature dependence of the upper critical fields μ0Hc2(T) of superconducting H3S under a record-high combination of applied pressures up to 160 GPa a...

journal_title：Nature communications

authors： Mozaffari S,Sun D,Minkov VS,Drozdov AP,Knyazev D,Betts JB,Einaga M,Shimizu K,Eremets MI,Balicas L,Balakirev FF

更新日期：2019-06-07 00:00:00

abstract：:A key element enabling the microelectronic technology advances of the past decades has been the conceptualization of complex circuits with versatile functionalities as being composed of the proper combination of basic 'lumped' circuit elements (for example, inductors and capacitors). In contrast, modern nanophotonic s...

journal_title：Nature communications

authors： Shi J,Monticone F,Elias S,Wu Y,Ratchford D,Li X,Alù A

更新日期：2014-05-29 00:00:00

abstract：:The spin of a single electron in a semiconductor quantum dot provides a well-controlled and long-lived qubit implementation. The electron charge in turn allows control of the position of individual electrons in a quantum dot array, and enables charge sensors to probe the charge configuration. Here we show that the Cou...

journal_title：Nature communications

authors： van Diepen CJ,Hsiao TK,Mukhopadhyay U,Reichl C,Wegscheider W,Vandersypen LMK

更新日期：2021-01-04 00:00:00

abstract：:Percolation in complex networks is a process that mimics network degradation and a tool that reveals peculiarities of the network structure. During the course of percolation, the emergent properties of networks undergo non-trivial transformations, which include a phase transition in the connectivity, and in some speci...

journal_title：Nature communications

authors： Kryven I

更新日期：2019-01-24 00:00:00

abstract：:Structural degradation and low conductivity of transition-metal oxides lead to severe capacity fading in lithium-ion batteries. Recent efforts to solve this issue have mainly focused on using nanocomposites or hybrids by integrating nanosized metal oxides with conducting additives. Here we design specific hierarchical...

journal_title：Nature communications

authors： Tan G,Wu F,Yuan Y,Chen R,Zhao T,Yao Y,Qian J,Liu J,Ye Y,Shahbazian-Yassar R,Lu J,Amine K

更新日期：2016-06-03 00:00:00

abstract：:MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...

journal_title：Nature communications

authors： Meng L,Liu C,Lü J,Zhao Q,Deng S,Wang G,Qiao J,Zhang C,Zhen L,Lu Y,Li W,Zhang Y,Pestell RG,Fan H,Chen YH,Liu Z,Yu Z

更新日期：2017-01-03 00:00:00

abstract：:Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be ...

journal_title：Nature communications

authors： Zalesskiy SS,Kitson PJ,Frei P,Bubliauskas A,Cronin L

更新日期：2019-12-02 00:00:00

abstract：:Understanding catalysts strain dynamic behaviours is crucial for the development of cost-effective, efficient, stable and long-lasting catalysts. Here, we reveal in situ three-dimensional strain evolution of single gold nanocrystals during a catalytic CO oxidation reaction under operando conditions with coherent X-ray...

journal_title：Nature communications

authors： Passos AR,Rochet A,Manente LM,Suzana AF,Harder R,Cha W,Meneau F

更新日期：2020-09-18 00:00:00

abstract：:Flicker or 1/f noise in metal-oxide-semiconductor field-effect transistors (MOSFETs) has been identified as the main source of noise at low frequency. It often originates from an ensemble of a huge number of charges becoming trapped and de-trapped. However, as a deviation from the well-known model of 1/f noise is obse...

journal_title：Nature communications

authors： Clément N,Nishiguchi K,Fujiwara A,Vuillaume D

更新日期：2010-10-19 00:00:00

abstract：:The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular ...

journal_title：Nature communications

authors： Ghosh D,Pinto S,Danglot L,Vandewauw I,Segal A,Van Ranst N,Benoit M,Janssens A,Vennekens R,Vanden Berghe P,Galli T,Vriens J,Voets T

更新日期：2016-02-04 00:00:00

abstract：:Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger body sizes than those observed at higher temperatures. The underlying molecular basis of this effect is poorly understood. Here we provide evidence that the temperature-dependent regulation of Drosoph...

journal_title：Nature communications

authors： Li Q,Gong Z

更新日期：2015-12-09 00:00:00

abstract：:Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...

journal_title：Nature communications

authors： Jin W,Kim HH,Ye Z,Ye G,Rojas L,Luo X,Yang B,Yin F,Horng JSA,Tian S,Fu Y,Xu G,Deng H,Lei H,Tsen AW,Sun K,He R,Zhao L

更新日期：2020-09-22 00:00:00

abstract：:Acoustic communication is enabled by the evolution of specialised hearing and sound producing organs. In this study, we performed a large-scale macroevolutionary study to understand how both hearing and sound production evolved and affected diversification in the insect order Orthoptera, which includes many familiar s...

journal_title：Nature communications

authors： Song H,Béthoux O,Shin S,Donath A,Letsch H,Liu S,McKenna DD,Meng G,Misof B,Podsiadlowski L,Zhou X,Wipfler B,Simon S

更新日期：2020-10-02 00:00:00