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Radiation-induced DNA damage and repair effects on 3D genome organization.

Abstract：

:The three-dimensional structure of chromosomes plays an important role in gene expression regulation and also influences the repair of radiation-induced DNA damage. Genomic aberrations that disrupt chromosome spatial domains can lead to diseases including cancer, but how the 3D genome structure responds to DNA damage is poorly understood. Here, we investigate the impact of DNA damage response and repair on 3D genome folding using Hi-C experiments on wild type cells and ataxia telangiectasia mutated (ATM) patient cells. We irradiate fibroblasts, lymphoblasts, and ATM-deficient fibroblasts with 5 Gy X-rays and perform Hi-C at 30 minutes, 24 hours, or 5 days after irradiation. We observe that 3D genome changes after irradiation are cell type-specific, with lymphoblastoid cells generally showing more contact changes than irradiated fibroblasts. However, all tested repair-proficient cell types exhibit an increased segregation of topologically associating domains (TADs). This TAD boundary strengthening after irradiation is not observed in ATM deficient fibroblasts and may indicate the presence of a mechanism to protect 3D genome structure integrity during DNA damage repair.

journal_name

Nat Commun

journal_title

Nature communications

authors

Sanders JT,Freeman TF,Xu Y,Golloshi R,Stallard MA,Hill AM,San Martin R,Balajee AS,McCord RP

doi

10.1038/s41467-020-20047-w

subject

Has Abstract

pub_date

2020-12-02 00:00:00

pages

6178

issue

1

issn

2041-1723

pii

10.1038/s41467-020-20047-w

journal_volume

11

pub_type

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