Abstract:
:The insulin/IGF-1 signalling (IIS) pathway plays an important role in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans. In this nematode, 40 insulin-like peptides (ILPs) have been identified as putative ligands of the IIS pathway; however, it remains unknown how ILPs modulate larval diapause. Here we show that the secretory polarity of INS-35 and INS-7, which suppress larval diapause, is changed in the intestinal epithelial cells at larval diapause. These ILPs are secreted from the intestine into the body cavity during larval stages. In contrast, they are secreted into the intestinal lumen and degraded during dauer arrest, only to be secreted into the body cavity again when the worms return to developmental growth. The process that determines the secretory polarity of INS-35 and INS-7, thus, has an important role in the modulation of larval diapause.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Matsunaga Y,Honda Y,Honda S,Iwasaki T,Qadota H,Benian GM,Kawano Tdoi
10.1038/ncomms10573subject
Has Abstractpub_date
2016-02-03 00:00:00pages
10573issn
2041-1723pii
ncomms10573journal_volume
7pub_type
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