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Radical cascade reaction of alkynes with N-fluoroarylsulfonimides and alcohols.

Abstract：

:Cascade reactions initiated by radical addition to alkynes are synthetically very attractive because they enable access to highly complex molecular skeletons in only few synthetic steps under usually mild conditions. Here we report a general radical cascade reaction of alkynes, N-fluoroarylsulfonimides and alcohols, enabling the efficient synthesis of important α-amino-α-aryl ketones from readily available starting materials via a single operation. During this process, the highly regioselective nitrogen-centred radical addition to internal and terminal alkynes generating vinyl radicals and the next explicit migration of aryl group from the nitrogen source lead the following efficient desulfonylation, oxygenation, and semi-pinacol rearrangement. In addition, the semi-pinacol rearrangement precursors, α-alkyloxyl-α,α-diaryl imines, could also be efficiently obtained under milder conditions. This methodology might open a new entry for designing intermolecular radical cascade reaction of alkynes.

journal_name

Nat Commun

journal_title

Nature communications

authors

Zheng G,Li Y,Han J,Xiong T,Zhang Q

doi

10.1038/ncomms8011

subject

Has Abstract

pub_date

2015-04-22 00:00:00

pages

7011

issn

2041-1723

pii

ncomms8011

journal_volume

6

pub_type

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