Author Correction: Analysis of human metabolism by reducing the complexity of the genome-scale models using redHUMAN.

abstract：:Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains essential metabolic functions of the liver, and autophagy-deficient murine models develop benign adenomas and hepatomegaly, which have been attributed to activat...

journal_title：Nature communications

authors： Lee YA,Noon LA,Akat KM,Ybanez MD,Lee TF,Berres ML,Fujiwara N,Goossens N,Chou HI,Parvin-Nejad FP,Khambu B,Kramer EGM,Gordon R,Pfleger C,Germain D,John GR,Campbell KN,Yue Z,Yin XM,Cuervo AM,Czaja MJ,Fiel MI,Hosh

更新日期：2018-11-23 00:00:00

abstract：:Granule cells are the dominant cell type of the olfactory bulb inhibiting mitral and tufted cells via dendrodendritic synapses; yet the factors regulating the strength of their inhibitory output, and, therefore, their impact on odour discrimination, remain unknown. Here we show that GABAAR β3-subunits are distributed ...

journal_title：Nature communications

authors： Nunes D,Kuner T

更新日期：2015-11-23 00:00:00

abstract：:Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer cells. Here, we report a lipid membrane-coated silica-carbon (LSC) hybrid nanoparticle that targets ...

journal_title：Nature communications

authors： Wang H,Gao Z,Liu X,Agarwal P,Zhao S,Conroy DW,Ji G,Yu J,Jaroniec CP,Liu Z,Lu X,Li X,He X

更新日期：2018-02-08 00:00:00

abstract：:Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by incre...

journal_title：Nature communications

authors： Novo D,Heath N,Mitchell L,Caligiuri G,MacFarlane A,Reijmer D,Charlton L,Knight J,Calka M,McGhee E,Dornier E,Sumpton D,Mason S,Echard A,Klinkert K,Secklehner J,Kruiswijk F,Vousden K,Macpherson IR,Blyth K,Bailey P,

更新日期：2018-11-29 00:00:00

abstract：:The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alterna...

journal_title：Nature communications

authors： Wang B,Tan XF,Thurmond S,Zhang ZM,Lin A,Hai R,Song J

更新日期：2017-03-27 00:00:00

abstract：:Various melting-related phenomena (like surface melting, size dependence of melting temperature, melting of few nm-size particles and overheating at a very fast heating rate) are of great fundamental and applied interest, although the corresponding theory is still lacking. Here we develop an advanced phase-field theor...

journal_title：Nature communications

authors： Levitas VI,Samani K

更新日期：2011-01-01 00:00:00

abstract：:CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major types of lipids, sphingolipids and phospholipids, but were ...

journal_title：Nature communications

authors： Shahine A,Reinink P,Reijneveld JF,Gras S,Holzheimer M,Cheng TY,Minnaard AJ,Altman JD,Lenz S,Prandi J,Kubler-Kielb J,Moody DB,Rossjohn J,Van Rhijn I

更新日期：2019-01-04 00:00:00

abstract：:Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...

journal_title：Nature communications

authors： Qi H,Zhang H,Zhao Y,Chen C,Long JJ,Chung WK,Guan Y,Shen Y

更新日期：2021-01-21 00:00:00

abstract：:Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell adaptor protein linke...

journal_title：Nature communications

authors： Raab M,Lu Y,Kohler K,Smith X,Strebhardt K,Rudd CE

更新日期：2017-07-12 00:00:00

abstract：:Hybrid organic-inorganic perovskites have attractive optoelectronic properties including exceptional solar cell performance. The improved properties of perovskites have been attributed to polaronic effects involving stabilization of localized charge character by structural deformations and polarizations. Here we exami...

journal_title：Nature communications

authors： Park M,Neukirch AJ,Reyes-Lillo SE,Lai M,Ellis SR,Dietze D,Neaton JB,Yang P,Tretiak S,Mathies RA

更新日期：2018-06-28 00:00:00

abstract：:Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the Uniform Manifold Approximation and Projection (UMAP) method on published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae. Proximity in low-dimensional UMAP space identifies groups of ge...

journal_title：Nature communications

authors： Dorrity MW,Saunders LM,Queitsch C,Fields S,Trapnell C

更新日期：2020-03-24 00:00:00

abstract：:As European heatwaves become more severe, summers in the United Kingdom (UK) are also getting warmer. The UK record temperature of 38.7 °C set in Cambridge in July 2019 prompts the question of whether exceeding 40 °C is now within reach. Here, we show how human influence is increasing the likelihood of exceeding 30, 3...

journal_title：Nature communications

authors： Christidis N,McCarthy M,Stott PA

更新日期：2020-06-30 00:00:00

abstract：:Transition-metal dissolution from cathode materials, manganese in particular, has been held responsible for severe capacity fading in lithium-ion batteries, with the deposition of the transition-metal cations on anode surface, in elemental form or as chelated-complexes, as the main contributor for such degradations. I...

journal_title：Nature communications

authors： Wang C,Xing L,Vatamanu J,Chen Z,Lan G,Li W,Xu K

更新日期：2019-07-31 00:00:00

abstract：:Combinatorial polyvalent contacts of histone-binding domains or readers commonly mediate localization and activities of chromatin-associated proteins. A pair of readers, the PHD fingers of the protein CHD4, has been shown to bivalently recognize histone H3 tails. Here we describe a mechanism by which these linked but ...

journal_title：Nature communications

authors： Gatchalian J,Wang X,Ikebe J,Cox KL,Tencer AH,Zhang Y,Burge NL,Di L,Gibson MD,Musselman CA,Poirier MG,Kono H,Hayes JJ,Kutateladze TG

更新日期：2017-11-14 00:00:00

abstract：:High-altitude pulmonary hypertension (HAPH) has heritable features and is a major cause of death in cattle in the Rocky Mountains, USA. Although multiple genes are likely involved in the genesis of HAPH, to date no major gene variant has been identified. Using whole-exome sequencing, we report the high association of ...

journal_title：Nature communications

authors： Newman JH,Holt TN,Cogan JD,Womack B,Phillips JA 3rd,Li C,Kendall Z,Stenmark KR,Thomas MG,Brown RD,Riddle SR,West JD,Hamid R

更新日期：2015-04-15 00:00:00

abstract：:Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost in EM recon...

journal_title：Nature communications

authors： Shen FY,Harrington MM,Walker LA,Cheng HPJ,Boyden ES,Cai D

更新日期：2020-09-15 00:00:00

abstract：:Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...

journal_title：Nature communications

authors： Inagaki H,Ohye T,Kogo H,Tsutsumi M,Kato T,Tong M,Emanuel BS,Kurahashi H

更新日期：2013-01-01 00:00:00

abstract：:Overcoming the restricted axonal regenerative ability that limits functional repair following a central nervous system injury remains a challenge. Here we report a regenerative paradigm that we call enriched conditioning, which combines environmental enrichment (EE) followed by a conditioning sciatic nerve axotomy tha...

journal_title：Nature communications

authors： De Virgiliis F,Hutson TH,Palmisano I,Amachree S,Miao J,Zhou L,Todorova R,Thompson R,Danzi MC,Lemmon VP,Bixby JL,Wittig I,Shah AM,Di Giovanni S

更新日期：2020-12-21 00:00:00

abstract：:The application of electron microscopy to hydrated biological samples has been limited by high-vacuum operating conditions. Traditional methods utilize harsh and laborious sample dehydration procedures, often leading to structural artefacts and creating difficulties for correlating results with high-resolution fluores...

journal_title：Nature communications

authors： Wojcik M,Hauser M,Li W,Moon S,Xu K

更新日期：2015-06-11 00:00:00

abstract：:Covalent organic frameworks (COFs) have served as a family of porous crystalline molecules for various promising applications. However, controllable synthesis of COFs with uniform morphology is paramount yet still remains quite challenging. Herein, we report self-templated synthesis of uniform and unique hollow sphere...

journal_title：Nature communications

authors： Liu YY,Li XC,Wang S,Cheng T,Yang H,Liu C,Gong Y,Lai WY,Huang W

更新日期：2020-11-03 00:00:00

abstract：:The original version of this Article contained an error in the author affiliations. Xiaochun Yu was incorrectly associated with College of Life Sciences, Hebei University, Baoding 071000 Hebei, China.This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Wang J,Yuan Z,Cui Y,Xie R,Yang G,Kassab MA,Wang M,Ma Y,Wu C,Yu X,Liu X

更新日期：2019-01-08 00:00:00

abstract：:Random numbers are commonly used in many different fields, ranging from simulations in fundamental science to security applications. In some critical cases, as Bell's tests and cryptography, the random numbers are required to be both private and to be provided at an ultra-fast rate. However, practical generators are u...

journal_title：Nature communications

authors： Avesani M,Marangon DG,Vallone G,Villoresi P

更新日期：2018-12-18 00:00:00

abstract：:Many voltage-gated potassium channels open in response to membrane depolarization and then inactivate within milliseconds. Neurons use these channels to tune their excitability. In Shaker K(+) channels, inactivation is caused by the cytoplasmic amino terminus, termed the inactivation gate. Despite having four such gat...

journal_title：Nature communications

authors： Venkataraman G,Srikumar D,Holmgren M

更新日期：2014-06-09 00:00:00

abstract：:Sensitive detection of protein interactions and post-translational modifications of native proteins is a challenge for research and diagnostic purposes. A method for this, which could be used in point-of-care devices and high-throughput screening, should be reliable, cost effective and robust. To achieve this, here we...

journal_title：Nature communications

authors： Koos B,Cane G,Grannas K,Löf L,Arngården L,Heldin J,Clausson CM,Klaesson A,Hirvonen MK,de Oliveira FM,Talibov VO,Pham NT,Auer M,Danielson UH,Haybaeck J,Kamali-Moghaddam M,Söderberg O

更新日期：2015-06-12 00:00:00

abstract：:Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the abilit...

journal_title：Nature communications

authors： Peng XL,Moffitt RA,Torphy RJ,Volmar KE,Yeh JJ

更新日期：2019-10-18 00:00:00

abstract：:The CRISPR/Cas9 system is a powerful tool for studying gene function. Here, we describe a method that allows temporal control of CRISPR/Cas9 activity based on conditional Cas9 destabilization. We demonstrate that fusing an FKBP12-derived destabilizing domain to Cas9 (DD-Cas9) enables conditional Cas9 expression and te...

journal_title：Nature communications

authors： Senturk S,Shirole NH,Nowak DG,Corbo V,Pal D,Vaughan A,Tuveson DA,Trotman LC,Kinney JB,Sordella R

更新日期：2017-02-22 00:00:00

abstract：:The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein's amino acids ('intra-gene epistasis'). Our limited understanding of such epistasis hinders the correct prediction of the funct...

journal_title：Nature communications

authors： Zurek PJ,Knyphausen P,Neufeld K,Pushpanath A,Hollfelder F

更新日期：2020-11-26 00:00:00

abstract：:To prevent new infections with human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa, UNAIDS recommends targeting interventions to populations that are at high risk of acquiring and passing on the virus. Yet it is often unclear who and where these 'source' populations are. Here we demonstrate how viral dee...

journal_title：Nature communications

authors： Ratmann O,Grabowski MK,Hall M,Golubchik T,Wymant C,Abeler-Dörner L,Bonsall D,Hoppe A,Brown AL,de Oliveira T,Gall A,Kellam P,Pillay D,Kagaayi J,Kigozi G,Quinn TC,Wawer MJ,Laeyendecker O,Serwadda D,Gray RH,Fraser C

更新日期：2019-03-29 00:00:00

abstract：:Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The...

journal_title：Nature communications

authors： Torres JP,Lin Z,Winter JM,Krug PJ,Schmidt EW

更新日期：2020-06-08 00:00:00

abstract：:Understanding how evolution of antimicrobial resistance increases resistance to other drugs is a challenge of profound importance. By combining experimental evolution and genome sequencing of 63 laboratory-evolved lines, we charted a map of cross-resistance interactions between antibiotics in Escherichia coli, and exp...

journal_title：Nature communications

authors： Lázár V,Nagy I,Spohn R,Csörgő B,Györkei Á,Nyerges Á,Horváth B,Vörös A,Busa-Fekete R,Hrtyan M,Bogos B,Méhi O,Fekete G,Szappanos B,Kégl B,Papp B,Pál C

更新日期：2014-07-08 00:00:00