A robust gene-stacking method utilizing yeast assembly for plant synthetic biology.

abstract：:Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...

journal_title：Nature communications

authors： Zhao K,Bruinsma R,Mason TG

更新日期：2012-05-01 00:00:00

abstract：:A non-classical light source emitting pairs of identical photons represents a versatile resource of interdisciplinary importance with applications in quantum optics and quantum biology. To date, photon twins have mostly been generated using parametric downconversion sources, relying on Poissonian number distributions,...

journal_title：Nature communications

authors： Heindel T,Thoma A,von Helversen M,Schmidt M,Schlehahn A,Gschrey M,Schnauber P,Schulze JH,Strittmatter A,Beyer J,Rodt S,Carmele A,Knorr A,Reitzenstein S

更新日期：2017-04-03 00:00:00

abstract：:Neurotransmitter/sodium symporters (NSSs) are responsible for Na+-dependent reuptake of neurotransmitters and represent key targets for antidepressants and psychostimulants. LeuT, a prokaryotic NSS protein, constitutes a primary structural model for these transporters. Here we show that K+ inhibits Na+-dependent bindi...

journal_title：Nature communications

authors： Billesbølle CB,Mortensen JS,Sohail A,Schmidt SG,Shi L,Sitte HH,Gether U,Loland CJ

更新日期：2016-09-28 00:00:00

abstract：:Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in...

journal_title：Nature communications

authors： Cheng K,Shen D,Hensley MT,Middleton R,Sun B,Liu W,De Couto G,Marbán E

更新日期：2014-09-10 00:00:00

abstract：:Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD...

journal_title：Nature communications

authors： Strohäker T,Jung BC,Liou SH,Fernandez CO,Riedel D,Becker S,Halliday GM,Bennati M,Kim WS,Lee SJ,Zweckstetter M

更新日期：2019-12-04 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms14778. ...

journal_title：Nature communications

authors： Li B,Bian K,Lane JMD,Salerno KM,Grest GS,Ao T,Hickman R,Wise J,Wang Z,Fan H

更新日期：2017-05-24 00:00:00

abstract：:Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles...

journal_title：Nature communications

authors： Xu X,Huang S,Zhang B,Huang F,Chi W,Fu J,Wang G,Li S,Jiang Q,Zhang C

更新日期：2017-04-27 00:00:00

abstract：:Current knowledge on chromosomal mosaicism in human cell cultures is mostly based on cytogenetic banding methods. The recent development of high-resolution full-genome analysis methods applicable to single cells is providing new insights into genetic and cellular diversity. Here we study the genetic content of 92 indi...

journal_title：Nature communications

authors： Jacobs K,Mertzanidou A,Geens M,Nguyen HT,Staessen C,Spits C

更新日期：2014-06-27 00:00:00

abstract：:Thermal conductivity of two-dimensional (2D) materials is of interest for energy storage, nanoelectronics and optoelectronics. Here, we report that the thermal conductivity of molybdenum disulfide can be modified by electrochemical intercalation. We observe distinct behaviour for thin films with vertically aligned bas...

journal_title：Nature communications

authors： Zhu G,Liu J,Zheng Q,Zhang R,Li D,Banerjee D,Cahill DG

更新日期：2016-10-21 00:00:00

abstract：:Natural killer (NK) cells are reported to have immunological memory, with CD49a+ liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the l...

journal_title：Nature communications

authors： Wang X,Peng H,Cong J,Wang X,Lian Z,Wei H,Sun R,Tian Z

更新日期：2018-11-19 00:00:00

abstract：:For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that inte...

journal_title：Nature communications

authors： Nordenfelt P,Elliott HL,Springer TA

更新日期：2016-10-10 00:00:00

abstract：:The evolutionary and environmental factors that shape fungal biogeography are incompletely understood. Here, we assemble a large dataset consisting of previously generated mycobiome data linked to specific geographical locations across the world. We use this dataset to describe the distribution of fungal taxa and to l...

journal_title：Nature communications

authors： Větrovský T,Kohout P,Kopecký M,Machac A,Man M,Bahnmann BD,Brabcová V,Choi J,Meszárošová L,Human ZR,Lepinay C,Lladó S,López-Mondéjar R,Martinović T,Mašínová T,Morais D,Navrátilová D,Odriozola I,Štursová M,Švec K,Tl

更新日期：2019-11-13 00:00:00

abstract：:Spinel transition metal oxides (TMOs) have emerged as promising anode materials for lithium-ion batteries. It has been shown that reducing their particle size to nanoscale dimensions benefits overall electrochemical performance. Here, we use in situ transmission electron microscopy to probe the lithiation behavior of ...

journal_title：Nature communications

authors： Li J,Meng Q,Zhang Y,Peng L,Yu G,Marschilok AC,Wu L,Su D,Takeuchi KJ,Takeuchi ES,Zhu Y,Stach EA

更新日期：2019-01-09 00:00:00

abstract：:We developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of which are spatially aligned and scaled according to the animal's weight, and hence provide...

journal_title：Nature communications

authors： Klose AD,Paragas N

更新日期：2018-10-15 00:00:00

abstract：:Most DNA in the genomes of higher organisms does not encode proteins, yet much is transcribed by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The biological significance of most lncRNAs is largely unclear. Here, we identify a lncRNA (SVALKA) in a cold-sensitive region of the Arabidopsis genome. Muta...

journal_title：Nature communications

authors： Kindgren P,Ard R,Ivanov M,Marquardt S

更新日期：2018-11-01 00:00:00

abstract：:A number of modes of oscillations of particles and fields can exist in space plasmas. Since the early 1970s, space missions have observed noise-like plasma waves near the geomagnetic equator known as 'equatorial noise'. Several theories were suggested, but clear observational evidence supported by realistic modelling ...

journal_title：Nature communications

authors： Balikhin MA,Shprits YY,Walker SN,Chen L,Cornilleau-Wehrlin N,Dandouras I,Santolik O,Carr C,Yearby KH,Weiss B

更新日期：2015-07-14 00:00:00

abstract：:Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity in floral traits, along with its recent genome sequence, makes mei an ideal model system for studying the evolution of woody plants. Here, we investigate the genetic architecture of floral trai...

journal_title：Nature communications

authors： Zhang Q,Zhang H,Sun L,Fan G,Ye M,Jiang L,Liu X,Ma K,Shi C,Bao F,Guan R,Han Y,Fu Y,Pan H,Chen Z,Li L,Wang J,Lv M,Zheng T,Yuan C,Zhou Y,Lee SM,Yan X,Xu X,Wu R,Chen W,Cheng T

更新日期：2018-04-27 00:00:00

abstract：:Plasmodium parasites possess a translocon that exports parasite proteins into the infected erythrocyte. Although the translocon components are also expressed during the mosquito and liver stage of infection, their function remains unexplored. Here, using a combination of genetic and chemical assays, we show that the t...

journal_title：Nature communications

authors： Mello-Vieira J,Enguita FJ,de Koning-Ward TF,Zuzarte-Luís V,Mota MM

更新日期：2020-11-06 00:00:00

abstract：:Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA activity for two highly specific SpCas9 variants (eSpCas9(1.1) and SpCas9...

journal_title：Nature communications

authors： Wang D,Zhang C,Wang B,Li B,Wang Q,Liu D,Wang H,Zhou Y,Shi L,Lan F,Wang Y

更新日期：2019-09-19 00:00:00

abstract：:Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...

journal_title：Nature communications

authors： Bernier NR,Tóth LD,Koottandavida A,Ioannou MA,Malz D,Nunnenkamp A,Feofanov AK,Kippenberg TJ

更新日期：2017-09-19 00:00:00

abstract：:Liquid crystalline phases of matter permeate nature and technology, with examples ranging from cell membranes to liquid-crystal displays. Remarkably, electronic liquid-crystal phases can exist in two-dimensional electron systems (2DES) at half Landau-level filling in the quantum Hall regime. Theory has predicted the e...

journal_title：Nature communications

authors： Qian Q,Nakamura J,Fallahi S,Gardner GC,Manfra MJ

更新日期：2017-11-16 00:00:00

abstract：:Engineering catalytic sites at the atomic level provides an opportunity to understand the catalyst's active sites, which is vital to the development of improved catalysts. Here we show a reliable and tunable polyoxometalate template-based synthetic strategy to atomically engineer metal doping sites onto metallic 1T-Mo...

journal_title：Nature communications

authors： Huang Y,Sun Y,Zheng X,Aoki T,Pattengale B,Huang J,He X,Bian W,Younan S,Williams N,Hu J,Ge J,Pu N,Yan X,Pan X,Zhang L,Wei Y,Gu J

更新日期：2019-02-28 00:00:00

abstract：:Thalamic inputs of cells in sensory cortices are outnumbered by local connections. Thus, it was suggested that robust sensory response in layer 4 emerges due to synchronized thalamic activity. To investigate the role of both inputs in the generation of correlated cortical activities, we isolated the thalamic excitator...

journal_title：Nature communications

authors： Cohen-Kashi Malina K,Mohar B,Rappaport AN,Lampl I

更新日期：2016-09-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from ALS patients with dif...

journal_title：Nature communications

authors： Guo W,Naujock M,Fumagalli L,Vandoorne T,Baatsen P,Boon R,Ordovás L,Patel A,Welters M,Vanwelden T,Geens N,Tricot T,Benoy V,Steyaert J,Lefebvre-Omar C,Boesmans W,Jarpe M,Sterneckert J,Wegner F,Petri S,Bohl D,Vande

更新日期：2017-10-11 00:00:00

abstract：:In recent years, the concept of metamaterials has offered platforms for unconventional tailoring and manipulation of the light-matter interaction. Here we explore the notion of 'static optics', in which the electricity and magnetism are decoupled, while the fields are temporally dynamic. This occurs when both the rela...

journal_title：Nature communications

authors： Mahmoud AM,Engheta N

更新日期：2014-12-05 00:00:00

abstract：:Understanding the response of granular matter to intrusion of solid objects is key to modelling many aspects of behaviour of granular matter, including plastic flow. Here we report a general model for such a quasistatic process. Using a range of experiments, we first show that the relation between the penetration dept...

journal_title：Nature communications

authors： Kang W,Feng Y,Liu C,Blumenfeld R

更新日期：2018-03-16 00:00:00

abstract：:Monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as protein tags and components of biosensors for deep-tissue imaging and multicolour microscopy. We report three bright and spectrally distinct monomeric NIR FPs, termed miRFPs, engineered from bacterial phytochrome, which can be used as easil...

journal_title：Nature communications

authors： Shcherbakova DM,Baloban M,Emelyanov AV,Brenowitz M,Guo P,Verkhusha VV

更新日期：2016-08-19 00:00:00

abstract：:The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E ...

journal_title：Nature communications

authors： Kawamura A,Münzel M,Kojima T,Yapp C,Bhushan B,Goto Y,Tumber A,Katoh T,King ON,Passioura T,Walport LJ,Hatch SB,Madden S,Müller S,Brennan PE,Chowdhury R,Hopkinson RJ,Suga H,Schofield CJ

更新日期：2017-04-06 00:00:00

abstract：:A key question in materials science is how fast properties evolve, which relates to the kinetics of phase transformations. In metals, kinetics is primarily connected to diffusion, which for substitutional elements is enabled via mobile atomic-lattice vacancies. In fact, non-equilibrium vacancies are often required for...

journal_title：Nature communications

authors： Dumitraschkewitz P,Uggowitzer PJ,Gerstl SSA,Löffler JF,Pogatscher S

更新日期：2019-10-18 00:00:00

abstract：:Increased aerobic glycolysis in endothelial cells of atheroprone areas of blood vessels has been hypothesized to drive increased inflammation and lesion burden but direct links remain to be established. Here we show that endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of prote...

journal_title：Nature communications

authors： Yang Q,Xu J,Ma Q,Liu Z,Sudhahar V,Cao Y,Wang L,Zeng X,Zhou Y,Zhang M,Xu Y,Wang Y,Weintraub NL,Zhang C,Fukai T,Wu C,Huang L,Han Z,Wang T,Fulton DJ,Hong M,Huo Y

更新日期：2018-11-07 00:00:00