Abstract:
:Plasmodium parasites possess a translocon that exports parasite proteins into the infected erythrocyte. Although the translocon components are also expressed during the mosquito and liver stage of infection, their function remains unexplored. Here, using a combination of genetic and chemical assays, we show that the translocon component Exported Protein 2 (EXP2) is critical for invasion of hepatocytes. EXP2 is a pore-forming protein that is secreted from the sporozoite upon contact with the host cell milieu. EXP2-deficient sporozoites are impaired in invasion, which can be rescued by the exogenous administration of recombinant EXP2 and alpha-hemolysin (an S. aureus pore-forming protein), as well as by acid sphingomyelinase. The latter, together with the negative impact of chemical and genetic inhibition of acid sphingomyelinase on invasion, reveals that EXP2 pore-forming activity induces hepatocyte membrane repair, which plays a key role in parasite invasion. Overall, our findings establish a novel and critical function for EXP2 that leads to an active participation of the host cell in Plasmodium sporozoite invasion, challenging the current view of the establishment of liver stage infection.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Mello-Vieira J,Enguita FJ,de Koning-Ward TF,Zuzarte-Luís V,Mota MMdoi
10.1038/s41467-020-19492-4subject
Has Abstractpub_date
2020-11-06 00:00:00pages
5654issue
1issn
2041-1723pii
10.1038/s41467-020-19492-4journal_volume
11pub_type
杂志文章abstract::Understanding the impact of rare variants is essential to understanding human health. We analyze rare (MAF < 0.1%) variants against 4264 phenotypes in 49,960 exome-sequenced individuals from the UK Biobank and 1934 phenotypes (1821 overlapping with UK Biobank) in 21,866 members of the Healthy Nevada Project (HNP) coho...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14288-y
更新日期:2020-01-28 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms14013. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms15795
更新日期:2017-08-14 00:00:00
abstract::Polyps of the cnidarian Hydra maintain their adult anatomy through two developmental organizers, the head organizer located apically and the foot organizer basally. The head organizer is made of two antagonistic cross-reacting components, an activator, driving apical differentiation and an inhibitor, preventing ectopi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08242-2
更新日期:2019-01-18 00:00:00
abstract::We currently have limited knowledge of the involvement of long non-coding RNAs (lncRNAs) in normal cellular processes and pathologies. Here, we identify and characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression in colorectal cancer. Depletion of SNHG5 induces cell cycle arrest and apoptosis in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13875
更新日期:2016-12-22 00:00:00
abstract::Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00341-w
更新日期:2017-08-02 00:00:00
abstract::Various viruses enter host cells via endocytosis, but the molecular mechanisms underlying the specific internalization pathways remain unclear. Here we show that influenza A viruses (IAVs) enter cells via redundant pathways of clathrin-mediated and clathrin-independent endocytosis, with intracellular Ca(2+) having a c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3763
更新日期:2013-01-01 00:00:00
abstract::How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of wh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11452-x
更新日期:2019-08-08 00:00:00
abstract::The efficiencies of green and red perovskite light-emitting diodes (PeLEDs) have been increased close to their theoretical upper limit, while the efficiency of blue PeLEDs is lagging far behind. Here we report enhancing the efficiency of sky-blue PeLEDs by overcoming a major hurdle of low photoluminescence quantum eff...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13580-w
更新日期:2019-12-10 00:00:00
abstract::Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory properties within immune cells. We report that SMCs synergize with innat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14278
更新日期:2017-02-15 00:00:00
abstract::Despite the growing evidence for the regulated spindle orientation in mammals, a systematic approach for identifying the responsible genes in mammalian cells has not been established. Here we perform a kinase-targeting RNAi screen in HeLa cells and identify ABL1 as a novel regulator of spindle orientation. Knockdown o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1634
更新日期:2012-01-17 00:00:00
abstract::To know the properties of a particle or a wave, one should measure how its energy changes with its momentum. The relation between them is called the dispersion relation, which encodes essential information of the kinetics. In a magnet, the wave motion of atomic spins serves as an elementary excitation, called a spin w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15859
更新日期:2017-06-12 00:00:00
abstract::Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10928
更新日期:2016-03-11 00:00:00
abstract::Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are derived from differentiation of oligodendrocyte progenitors through a process requiring cell cycle exit and histone modifications. Here we identify the histone arginine methyl-transferase PRMT5, a molecule catalyzing symmetric ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04863-9
更新日期:2018-07-19 00:00:00
abstract::Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3846
更新日期:2013-01-01 00:00:00
abstract::Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are due in part to different C2H2 zinc-finger (ZF) transcription factors, IKZF1 (or IKZF3) and SALL4, respectively. Here, we report the structural bases for the SA...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18488-4
更新日期:2020-09-14 00:00:00
abstract::Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13484
更新日期:2016-11-16 00:00:00
abstract::Due to the surge of natural gas production, feedstocks for chemicals shift towards lighter hydrocarbons, particularly methane. The success of a Gas-to-Chemicals process via synthesis gas (CO and H2) depends on the ability of catalysts to suppress methane and carbon dioxide formation. We designed a Co/Mn/Na/S catalyst,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08019-7
更新日期:2019-01-11 00:00:00
abstract::All-inorganic perovskites have a special place in halide perovskite family because of their potential for better stability. However, the representative cesium lead iodide (CsPbI3) is metastable and spontaneously converts to the non-perovskite structure at room temperature. Here, we demonstrate that what appears to be ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07204-y
更新日期:2018-11-14 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17712-5
更新日期:2020-07-27 00:00:00
abstract::Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09794-7
更新日期:2019-04-23 00:00:00
abstract::Antiretroviral therapy (ART) suppresses viral replication in people living with HIV. Yet, infected cells persist for decades on ART and viremia returns if ART is stopped. Persistence has been attributed to viral replication in an ART sanctuary and long-lived and/or proliferating latently infected cells. Using ecologic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06843-5
更新日期:2018-11-16 00:00:00
abstract::The ability to modulate light at high speeds is of paramount importance for telecommunications, information processing and medical imaging technologies. This has stimulated intense efforts to master optoelectronic switching at visible and near-infrared frequencies, although coping with current computer speeds in integ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4548
更新日期:2014-03-27 00:00:00
abstract::Motile plant structures such as Mimosa pudica leaves, Impatiens glandulifera seedpods, and Dionaea muscipula leaves exhibit fast nastic movements in a few seconds or less. This motion is stimuli-independent mechanical movement following theorema egregium rules. Artificial analogs of tropistic motion in plants are exem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20843-4
更新日期:2021-01-21 00:00:00
abstract::The Dansgaard-Oeschger (DO) events, as observed in oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record, are an outstanding example of past abrupt climate transitions. Their physical cause remains debated, and previous research indicated that they are not preceded by classical early-warning s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04881-7
更新日期:2018-07-02 00:00:00
abstract::Noble metal nanoparticles stabilized by organic ligands are important for applications in assembly, site-specific bioconjugate labelling and sensing, drug delivery and medical therapy, molecular recognition and molecular electronics, and catalysis. Here we report crystal structures and theoretical analysis of three Ag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3422
更新日期:2013-01-01 00:00:00
abstract::One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1710
更新日期:2012-02-28 00:00:00
abstract::Coupling between vibrational modes is essential for energy transfer and dissipation in condensed matter. For water, different O-H stretch modes are known to be very strongly coupled both within and between water molecules, leading to ultrafast dissipation and delocalization of vibrational energy. In contrast, the info...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19759-w
更新日期:2020-11-25 00:00:00
abstract::Interactions between a protein and a ligand are essential to all biological processes. Binding and dissociation are the two fundamental steps of ligand-protein interactions, and determine the binding affinity. Intrinsic conformational dynamics of proteins have been suggested to play crucial roles in ligand binding and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4724
更新日期:2014-04-24 00:00:00
abstract::Engineering lattice thermal conductivity requires to control the heat carried by atomic vibration waves, the phonons. The key parameter for quantifying it is the phonon lifetime, limiting the travelling distance, whose determination is however at the limits of instrumental capabilities. Here, we show the achievement o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00584-7
更新日期:2017-09-08 00:00:00
abstract::DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17531-8
更新日期:2020-07-24 00:00:00