An unexpected protein interaction promotes drug resistance in leukemia.

abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...

journal_title：Nature communications

authors： Pan Y,Ren Z,Gao S,Shen J,Wang L,Xu Z,Yu Y,Bachina P,Zhang H,Fan X,Laganowsky A,Yan N,Zhou M

更新日期：2020-11-10 00:00:00

abstract：:The two-dimensional topological insulators host a full gap in the bulk band, induced by spin-orbit coupling (SOC) effect, together with the topologically protected gapless edge states. However, it is usually challenging to suppress the bulk conductance and thus to realize the quantum spin Hall (QSH) effect. In this st...

journal_title：Nature communications

authors： Song YH,Jia ZY,Zhang D,Zhu XY,Shi ZQ,Wang H,Zhu L,Yuan QQ,Zhang H,Xing DY,Li SC

更新日期：2018-10-04 00:00:00

abstract：:Do completely unpredictable events exist? Classical physics excludes fundamental randomness. Although quantum theory makes probabilistic predictions, this does not imply that nature is random, as randomness should be certified without relying on the complete structure of the theory being used. Bell tests approach the ...

journal_title：Nature communications

authors： Gallego R,Masanes L,De La Torre G,Dhara C,Aolita L,Acín A

更新日期：2013-01-01 00:00:00

abstract：:Various platinum-free electrocatalysts have been explored for hydrogen evolution reaction in acidic solutions. However, in economical water-alkali electrolysers, sluggish water dissociation kinetics (Volmer step) on platinum-free electrocatalysts results in poor hydrogen-production activities. Here we report a MoNi4 e...

journal_title：Nature communications

authors： Zhang J,Wang T,Liu P,Liao Z,Liu S,Zhuang X,Chen M,Zschech E,Feng X

更新日期：2017-05-17 00:00:00

abstract：:In certain artistic endeavours-such as acting in films and TV, where unemployment rates hover at around 90%-sustained productivity (simply making a living) is probably a better proxy for quantifying success than high impact. Drawing on a worldwide database, here we study the temporal profiles of activity of actors and...

journal_title：Nature communications

authors： Williams OE,Lacasa L,Latora V

更新日期：2019-06-04 00:00:00

abstract：:Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs. The genetic tools available for engineering intercellular signaling, however, are quite limited. Here we exploit the chemical diversity of biological small molecules to de novo design ...

journal_title：Nature communications

authors： Du P,Zhao H,Zhang H,Wang R,Huang J,Tian Y,Luo X,Luo X,Wang M,Xiang Y,Qian L,Chen Y,Tao Y,Lou C

更新日期：2020-08-24 00:00:00

abstract：:Topological nodal line semimetals, a novel quantum state of materials, possess topologically nontrivial valence and conduction bands that touch at a line near the Fermi level. The exotic band structure can lead to various novel properties, such as long-range Coulomb interaction and flat Landau levels. Recently, topolo...

journal_title：Nature communications

authors： Feng B,Fu B,Kasamatsu S,Ito S,Cheng P,Liu CC,Feng Y,Wu S,Mahatha SK,Sheverdyaeva P,Moras P,Arita M,Sugino O,Chiang TC,Shimada K,Miyamoto K,Okuda T,Wu K,Chen L,Yao Y,Matsuda I

更新日期：2017-10-18 00:00:00

abstract：:The importance of the tumor-associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show that in the mammary glands of non-tumor bearing mice, stromal-specific phosphatase and tensin homolog (Pten) delet...

journal_title：Nature communications

authors： Sizemore GM,Balakrishnan S,Thies KA,Hammer AM,Sizemore ST,Trimboli AJ,Cuitiño MC,Steck SA,Tozbikian G,Kladney RD,Shinde N,Das M,Park D,Majumder S,Krishnan S,Yu L,Fernandez SA,Chakravarti A,Shields PG,White JR,Yee

更新日期：2018-07-17 00:00:00

abstract：:Histone acetylation is known to affect the speed of seed germination, but the molecular regulatory basis of this remains ambiguous. Here we report that loss of function of two histone deacetylase-binding factors, SWI-INDEPENDENT3 (SIN3)-LIKE1 (SNL1) and SNL2, results in accelerated radicle protrusion and growth during...

journal_title：Nature communications

authors： Wang Z,Chen F,Li X,Cao H,Ding M,Zhang C,Zuo J,Xu C,Xu J,Deng X,Xiang Y,Soppe WJ,Liu Y

更新日期：2016-11-11 00:00:00

abstract：:There are concerns that pneumococcal conjugate vaccines (PCVs) in sub-Saharan Africa sub-optimally interrupt Streptococcus pneumoniae vaccine-serotype (VT) carriage and transmission. Here we assess PCV carriage using rolling, prospective nasopharyngeal carriage surveys between 2015 and 2018, 3.6-7.1 years after Malawi...

journal_title：Nature communications

authors： Swarthout TD,Fronterre C,Lourenço J,Obolski U,Gori A,Bar-Zeev N,Everett D,Kamng'ona AW,Mwalukomo TS,Mataya AA,Mwansambo C,Banda M,Gupta S,Diggle P,French N,Heyderman RS

更新日期：2020-05-06 00:00:00

abstract：:The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumour cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site. WC-21, a sigma-2 ligand containing both a photoactive azide moiety and a fluorescein isoth...

journal_title：Nature communications

authors： Xu J,Zeng C,Chu W,Pan F,Rothfuss JM,Zhang F,Tu Z,Zhou D,Zeng D,Vangveravong S,Johnston F,Spitzer D,Chang KC,Hotchkiss RS,Hawkins WG,Wheeler KT,Mach RH

更新日期：2011-07-05 00:00:00

abstract：:Surface charge density is the key factor for developing high performance triboelectric nanogenerators (TENG). The previously invented charge excitation TENG provides a most efficient way to achieve maximum charge output of a TENG device. Herein, criteria to quantitatively evaluate the contact efficiency and air breakd...

journal_title：Nature communications

authors： Liu Y,Liu W,Wang Z,He W,Tang Q,Xi Y,Wang X,Guo H,Hu C

更新日期：2020-03-27 00:00:00

abstract：:Memory consolidation requires a timely controlled interplay between the hippocampus, a brain region important for memory formation, and the cortex, a region recruited for memory storage. Here we show that memory consolidation is associated with specific epigenetic modifications on histone proteins that have a distinct...

journal_title：Nature communications

authors： Gräff J,Woldemichael BT,Berchtold D,Dewarrat G,Mansuy IM

更新日期：2012-01-01 00:00:00

abstract：:All-optical approaches to particle acceleration are currently attracting a significant research effort internationally. Although characterized by exceptional transverse and longitudinal emittance, laser-driven ion beams currently have limitations in terms of peak ion energy, bandwidth of the energy spectrum and beam d...

journal_title：Nature communications

authors： Kar S,Ahmed H,Prasad R,Cerchez M,Brauckmann S,Aurand B,Cantono G,Hadjisolomou P,Lewis CL,Macchi A,Nersisyan G,Robinson AP,Schroer AM,Swantusch M,Zepf M,Willi O,Borghesi M

更新日期：2016-04-18 00:00:00

abstract：:Solid substrates often induce non-uniform strain and doping in graphene monolayer, therefore altering the intrinsic properties of graphene, reducing its charge carrier mobilities and, consequently, the overall electrical performance. Here, we exploit confocal Raman spectroscopy to study graphene directly free-floating...

journal_title：Nature communications

authors： Belyaeva LA,Jiang L,Soleimani A,Methorst J,Risselada HJ,Schneider GF

更新日期：2020-02-14 00:00:00

abstract：:Micro-optics are widely used in numerous applications, such as beam shaping, collimation, focusing and imaging. We use femtosecond 3D printing to manufacture free-form micro-optical elements. Our method gives sub-micrometre accuracy so that direct manufacturing even on single-mode fibres is possible. We demonstrate th...

journal_title：Nature communications

authors： Gissibl T,Thiele S,Herkommer A,Giessen H

更新日期：2016-06-24 00:00:00

abstract：:Macrophages are a major immune cell type infiltrating tumors and promoting tumor growth and metastasis. To elucidate the mechanism of macrophage recruitment, we utilize an overgrowth tumor model ("undead" model) in larval Drosophila imaginal discs that are attached by numerous macrophages. Here we report that changes ...

journal_title：Nature communications

authors： Diwanji N,Bergmann A

更新日期：2020-07-20 00:00:00

abstract：:Visual brain areas exhibit tuning characteristics well suited for image statistics present in our natural environment. However, visual sensation is an active process, and if there are any brain areas that ought to be particularly in tune with natural scene statistics, it would be sensory-motor areas critical for guidi...

journal_title：Nature communications

authors： Chen CY,Sonnenberg L,Weller S,Witschel T,Hafed ZM

更新日期：2018-07-20 00:00:00

abstract：:Understanding the dynamics of ring polymers is a particularly challenging yet interesting problem in soft materials. Despite recent progress, a complete understanding of the nonequilibrium behavior of ring polymers has not yet been achieved. In this work, we directly observe the flow dynamics of DNA-based rings in sem...

journal_title：Nature communications

authors： Zhou Y,Hsiao KW,Regan KE,Kong D,McKenna GB,Robertson-Anderson RM,Schroeder CM

更新日期：2019-04-15 00:00:00

abstract：:A key question in materials science is how fast properties evolve, which relates to the kinetics of phase transformations. In metals, kinetics is primarily connected to diffusion, which for substitutional elements is enabled via mobile atomic-lattice vacancies. In fact, non-equilibrium vacancies are often required for...

journal_title：Nature communications

authors： Dumitraschkewitz P,Uggowitzer PJ,Gerstl SSA,Löffler JF,Pogatscher S

更新日期：2019-10-18 00:00:00

abstract：:Viruses provide top-down control on microbial communities, yet their direct study in natural environments was hindered by culture limitations. The advance of bioinformatics enables cultivation-independent study of viruses. Many studies assemble new viral genomes and study viral diversity using marker genes from free v...

journal_title：Nature communications

authors： Sieradzki ET,Ignacio-Espinoza JC,Needham DM,Fichot EB,Fuhrman JA

更新日期：2019-03-12 00:00:00

abstract：:New microbial genomes are constantly being sequenced, and it is crucial to accurately determine their taxonomic identities and evolutionary relationships. Here we report PhyloPhlAn, a new method to assign microbial phylogeny and putative taxonomy using >400 proteins optimized from among 3,737 genomes. This method meas...

journal_title：Nature communications

authors： Segata N,Börnigen D,Morgan XC,Huttenhower C

更新日期：2013-01-01 00:00:00

abstract：:ATP-dependent chromatin remodellers are mutated in more than 20% of human cancers. The consequences of these mutations on enzyme function are poorly understood. Here, we characterise the effects of CHD4 mutations identified in endometrial carcinoma on the remodelling properties of dMi-2, the highly conserved Drosophil...

journal_title：Nature communications

authors： Kovač K,Sauer A,Mačinković I,Awe S,Finkernagel F,Hoffmeister H,Fuchs A,Müller R,Rathke C,Längst G,Brehm A

更新日期：2018-05-29 00:00:00

abstract：:Thalamic inputs of cells in sensory cortices are outnumbered by local connections. Thus, it was suggested that robust sensory response in layer 4 emerges due to synchronized thalamic activity. To investigate the role of both inputs in the generation of correlated cortical activities, we isolated the thalamic excitator...

journal_title：Nature communications

authors： Cohen-Kashi Malina K,Mohar B,Rappaport AN,Lampl I

更新日期：2016-09-12 00:00:00

abstract：:Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities...

journal_title：Nature communications

authors： Yeung CT,Yim KH,Wong HY,Pal R,Lo WS,Yan SC,Yee-Man Wong M,Yufit D,Smiles DE,McCormick LJ,Teat SJ,Shuh DK,Wong WT,Law GL

更新日期：2017-10-24 00:00:00

abstract：:The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data. We identify a total of 201 transc...

journal_title：Nature communications

authors： Whisnant AW,Jürges CS,Hennig T,Wyler E,Prusty B,Rutkowski AJ,L'hernault A,Djakovic L,Göbel M,Döring K,Menegatti J,Antrobus R,Matheson NJ,Künzig FWH,Mastrobuoni G,Bielow C,Kempa S,Liang C,Dandekar T,Zimmer R,Landth

更新日期：2020-04-27 00:00:00

abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

journal_title：Nature communications

authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

更新日期：2021-01-28 00:00:00

abstract：:Metal-organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemica...

journal_title：Nature communications

authors： Wei TH,Wu SH,Huang YD,Lo WS,Williams BP,Chen SY,Yang HC,Hsu YS,Lin ZY,Chen XH,Kuo PE,Chou LY,Tsung CK,Shieh FK

更新日期：2019-11-01 00:00:00

abstract：:The genome of the thermophilic bacterium, Aeribacillus pallidus 8, encodes the bacteriocin pallidocin. It belongs to the small class of glycocins and is posttranslationally modified, containing an S-linked glucose on a specific Cys residue. In this study, the pallidocin biosynthetic machinery is cloned and expressed i...

journal_title：Nature communications

authors： Kaunietis A,Buivydas A,Čitavičius DJ,Kuipers OP

更新日期：2019-03-07 00:00:00

abstract：:Microbial symbiosis is integral to plant growth and reproduction, but its contribution to global patterns of plant distribution is unknown. Legumes (Fabaceae) are a diverse and widely distributed plant family largely dependent on symbiosis with nitrogen-fixing rhizobia, which are acquired from soil after germination. ...

journal_title：Nature communications

authors： Simonsen AK,Dinnage R,Barrett LG,Prober SM,Thrall PH

更新日期：2017-04-07 00:00:00