Abstract:
:There are concerns that pneumococcal conjugate vaccines (PCVs) in sub-Saharan Africa sub-optimally interrupt Streptococcus pneumoniae vaccine-serotype (VT) carriage and transmission. Here we assess PCV carriage using rolling, prospective nasopharyngeal carriage surveys between 2015 and 2018, 3.6-7.1 years after Malawi's 2011 PCV13 introduction. Carriage decay rate is analysed using non-linear regression. Despite evidence of reduction in VT carriage over the study period, there is high persistent residual carriage. This includes among PCV-vaccinated children 3-5-year-old (16.1% relative reduction from 19.9% to 16.7%); PCV-unvaccinated children 6-8-year-old (40.5% reduction from 26.4% to 15.7%); HIV-infected adults 18-40-years-old on antiretroviral therapy (41.4% reduction from 15.2% to 8.9%). VT carriage prevalence half-life is similar among PCV-vaccinated and PCV-unvaccinated children (3.26 and 3.34 years, respectively). Compared with high-income settings, there is high residual VT carriage 3.6-7.1 years after PCV introduction. Rigorous evaluation of strategies to augment vaccine-induced control of carriage, including alternative schedules and catch-up campaigns, is required.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Swarthout TD,Fronterre C,Lourenço J,Obolski U,Gori A,Bar-Zeev N,Everett D,Kamng'ona AW,Mwalukomo TS,Mataya AA,Mwansambo C,Banda M,Gupta S,Diggle P,French N,Heyderman RSdoi
10.1038/s41467-020-15786-9subject
Has Abstractpub_date
2020-05-06 00:00:00pages
2222issue
1issn
2041-1723pii
10.1038/s41467-020-15786-9journal_volume
11pub_type
杂志文章abstract::Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces statistical variability and inaccurate re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09439-9
更新日期:2019-04-01 00:00:00
abstract::Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage. However, little is known about genomic changes during natural colonisation. Here, we use whole-genome sequencing to investigate within-host microevolu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17327-w
更新日期:2020-07-10 00:00:00
abstract::For many stochastic processes, the probability [Formula: see text] of not-having reached a target in unbounded space up to time [Formula: see text] follows a slow algebraic decay at long times, [Formula: see text]. This is typically the case of symmetric compact (i.e. recurrent) random walks. While the persistence exp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10841-6
更新日期:2019-07-05 00:00:00
abstract::The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1115
更新日期:2010-11-16 00:00:00
abstract::Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles of organ-residing LVs are underinvestigated. Here we show that lymphatic endothelial cells (LECs), a component of LVs within pre-metastatic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5715
更新日期:2014-09-02 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14601-9
更新日期:2020-02-06 00:00:00
abstract::The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose a scan statistic framework, WGScan, to simultaneously detect the existence, and estimate t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11023-0
更新日期:2019-07-09 00:00:00
abstract::Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer transcription factors have prominent roles in this process because of their ability to contact their cognate binding motifs in closed chromatin. Reprogramming is pervasive in plants, whose development is plastic and tuned by the envi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20883-w
更新日期:2021-01-27 00:00:00
abstract::One of the main reasons why nonlinear-optical signal processing (regeneration, logic, etc.) has not yet become a practical alternative to electronic processing is that the all-optical elements with nonlinear input-output relationship have remained inherently single-channel devices (just like their electronic counterpa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00874-0
更新日期:2017-10-12 00:00:00
abstract::Crystallization by particle attachment is impacting our understanding of natural mineralization processes and holds promise for novel materials design. When particles assemble in crystallographic alignment, expulsion of the intervening solvent and particle coalescence are enabled by near-perfect co-alignment via inter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00844-6
更新日期:2017-10-10 00:00:00
abstract::With favourable error thresholds and requiring only nearest-neighbour interactions on a lattice, the surface code is an error-correcting code that has garnered considerable attention. At the heart of this code is the ability to perform a low-weight parity measurement of local code qubits. Here we demonstrate high-fide...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5015
更新日期:2014-06-24 00:00:00
abstract::Chemical utilization of vast fossil and renewable feedstocks of methane remains one of the most important challenges of modern chemistry. Herein, we report direct and selective methane photocatalytic oxidation at ambient conditions into carbon monoxide, which is an important chemical intermediate and a platform molecu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08525-2
更新日期:2019-02-11 00:00:00
abstract::The Amazon river basin receives ~2000 mm of precipitation annually and contributes ~17% of global river freshwater input to the oceans; its hydroclimatic variations can exert profound impacts on the marine ecosystem in the Amazon plume region (APR) and have potential far-reaching influences on hydroclimate over the tr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18187-0
更新日期:2020-09-01 00:00:00
abstract::Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show that the human clamp PCNA recognizes DNA through a double patch of basic residue...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13935
更新日期:2017-01-10 00:00:00
abstract::Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18208-y
更新日期:2020-08-28 00:00:00
abstract::Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14229
更新日期:2017-02-06 00:00:00
abstract::Autophagy is the major cellular pathway by which macromolecules are degraded, and amino acid depletion powerfully activates autophagy. MAP4K3, or germinal-center kinase-like kinase, is required for robust cell growth in response to amino acids, but the basis for MAP4K3 regulation of cellular metabolic disposition rema...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03340-7
更新日期:2018-03-05 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-18712-1
更新日期:2020-09-16 00:00:00
abstract::LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09711-y
更新日期:2019-05-20 00:00:00
abstract::Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators. Here, we apply unsupervised machine learning to a diverse compendium of over 250 ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13483-w
更新日期:2019-12-04 00:00:00
abstract::The respiratory chain in mitochondria is composed of membrane-bound proteins that couple electron transfer to proton translocation across the inner membrane. These charge-transfer reactions are regulated by the proton electrochemical gradient that is generated and maintained by the transmembrane charge transfer. Here,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05615-5
更新日期:2018-08-09 00:00:00
abstract::The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alterna...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14763
更新日期:2017-03-27 00:00:00
abstract::To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon stati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13402-z
更新日期:2019-12-03 00:00:00
abstract::Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12295-2
更新日期:2019-09-20 00:00:00
abstract::Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14791
更新日期:2017-03-24 00:00:00
abstract::Paternal epigenetic inheritance is gaining attention for its growing medical relevance. However, the form in which paternal epigenetic information is transmitted to offspring and how it influences offspring development remain poorly understood. Here we show that in C. elegans, sperm-inherited chromatin states transmit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09141-w
更新日期:2019-03-20 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-10951-1
更新日期:2019-07-01 00:00:00
abstract::Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymerize outward from adhesion sites to push membranes towards distant sit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18586-3
更新日期:2020-09-23 00:00:00
abstract::New capabilities at X-ray free-electron laser facilities allow the generation of two-colour femtosecond X-ray pulses, opening the possibility of performing ultrafast studies of X-ray-induced phenomena. Particularly, the experimental realization of hetero-site-specific X-ray-pump/X-ray-probe spectroscopy is of special ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11652
更新日期:2016-05-23 00:00:00
abstract::Fatigue is a difficult multi-scale modelling problem nucleating from localised plasticity at the scale of dislocations and microstructure with significant engineering safety implications. Cold dwell fatigue is a phenomenon in titanium where stress holds at moderate temperatures lead to substantial reductions in cyclic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19470-w
更新日期:2020-11-17 00:00:00