Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yang C,Eleftheriadou M,Kelaini S,Morrison T,González MV,Caines R,Edwards N,Yacoub A,Edgar K,Moez A,Ivetic A,Zampetaki A,Zeng L,Wilkinson FL,Lois N,Stitt AW,Grieve DJ,Margariti Adoi
10.1038/s41467-020-18712-1subject
Has Abstractpub_date
2020-09-16 00:00:00pages
4770issue
1issn
2041-1723pii
10.1038/s41467-020-18712-1journal_volume
11pub_type
杂志文章,已发布勘误abstract::Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor ce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05473-1
更新日期:2018-08-03 00:00:00
abstract::The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we add...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18634-y
更新日期:2020-09-25 00:00:00
abstract::The transcription factor BMAL1 is a core component of the molecular clock, regulating biological pathways that drive 24 h (circadian) rhythms in behaviour and physiology. The molecular clock has a profound influence on innate immune function, and circadian disruption is linked with increased incidence of multiple scle...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02111-0
更新日期:2017-12-12 00:00:00
abstract::The HIRA histone chaperone complex deposits the histone variant H3.3 onto chromatin in a DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and CABIN1, however the functional oligomerization state of the complex has not been investigated. Here we use biochemical and crystallographic a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05581-y
更新日期:2018-08-06 00:00:00
abstract::Effective prevention strategies will be essential in reducing disease burden due to bacterial infections. Here we harness the specificity and rapid-acting properties of bacteriophages as a potential prophylaxis therapy for cholera, a severely dehydrating disease caused by Vibrio cholerae. To this end, we test a cockta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14187
更新日期:2017-02-01 00:00:00
abstract::The magnetic excitations in the cuprate superconductors might be essential for an understanding of high-temperature superconductivity. In these cuprate superconductors the magnetic excitation spectrum resembles an hour-glass and certain resonant magnetic excitations within are believed to be connected to the pairing m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6731
更新日期:2014-12-23 00:00:00
abstract::Supersymmetry is a conjectured symmetry between bosons and fermions aiming at solving fundamental questions in string and quantum field theory. Its subsequent application to quantum mechanics led to a ground-breaking analysis and design machinery, later fruitfully extrapolated to photonics. In all cases, the algebraic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14634-0
更新日期:2020-02-10 00:00:00
abstract::Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08060-6
更新日期:2019-01-14 00:00:00
abstract::The growth of large-domain single crystalline graphene with the controllable number of layers is of central importance for large-scale integration of graphene devices. Here we report a new pathway to greatly reduce the graphene nucleation density from ~10(6) to 4 nuclei cm(-2), enabling the growth of giant single crys...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3096
更新日期:2013-01-01 00:00:00
abstract::Zinc-finger nuclease, transcription activator-like effector nuclease and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are becoming major tools for genome editing. Importantly, knock-in in several non-rodent species has been finally achieved thanks to these custo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10548
更新日期:2016-01-28 00:00:00
abstract::The 'phonon-glass electron-crystal' concept has triggered most of the progress that has been achieved in inorganic thermoelectrics in the past two decades. Organic thermoelectric materials, unlike their inorganic counterparts, exhibit molecular diversity, flexible mechanical properties and easy fabrication, and are mo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19537-8
更新日期:2020-11-10 00:00:00
abstract::Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics. Here we describe the design and development of the Alphabody, a protein scaffold featuring a single-chain antiparallel triple-helix coiled-coil fold. We report affinity-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6237
更新日期:2014-10-30 00:00:00
abstract::Cas9/gRNA-mediated gene-drive systems have advanced development of genetic technologies for controlling vector-borne pathogen transmission. These technologies include population suppression approaches, genetic analogs of insecticidal techniques that reduce the number of insect vectors, and population modification (rep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19426-0
更新日期:2020-11-03 00:00:00
abstract::In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03545-w
更新日期:2018-03-28 00:00:00
abstract::Noble metal nanoparticles stabilized by organic ligands are important for applications in assembly, site-specific bioconjugate labelling and sensing, drug delivery and medical therapy, molecular recognition and molecular electronics, and catalysis. Here we report crystal structures and theoretical analysis of three Ag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3422
更新日期:2013-01-01 00:00:00
abstract::The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12769
更新日期:2016-09-14 00:00:00
abstract::The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (E...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11058-3
更新日期:2019-07-12 00:00:00
abstract::Translatome reprogramming is a primary determinant of protein levels during stimuli adaptation. This raises the question: what are the translatome remodelers that reprogram protein output to activate biochemical adaptations. Here, we identify a translational pathway that represses metabolism to safeguard genome integr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19602-2
更新日期:2020-11-13 00:00:00
abstract::In the original version of this Article, an incorrect sample size was provided for the number of relict species (443 instead of 442) and the number of relict forests (423 instead of 422). These errors have been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-07727-4
更新日期:2018-12-04 00:00:00
abstract::A key challenge in the field of molecular spintronics, and for the design of single-molecule magnet-based devices in particular, is the understanding and control of the molecular coupling at the electrode interfaces. It was demonstrated for the field of molecular electronics that the characterization of the molecule-m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1953
更新日期:2012-07-17 00:00:00
abstract::Striated muscle contraction is regulated by the translocation of troponin-tropomyosin strands over the thin filament surface. Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts between actin and tropomyosin, which position tropomyosin such that it impedes actomyosin association...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15922-5
更新日期:2020-05-15 00:00:00
abstract::The divalent carbene carbon centre in cyclic (alkyl)(amino)carbenes (CAACs) is known to exhibit transition-metal-like insertion into E-H σ-bonds (E = H, N, Si, B, P, C, O) with formation of new, strong C-E and C-H bonds. Although subsequent transformations of the products represent an attractive strategy for metal-fre...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08967-8
更新日期:2019-03-26 00:00:00
abstract::In all of the diverse areas of science where waves play an important role, one of the most fundamental solutions of the corresponding wave equation is a stationary wave with constant intensity. The most familiar example is that of a plane wave propagating in free space. In the presence of any Hermitian potential, a wa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8257
更新日期:2015-07-08 00:00:00
abstract::Two-Photon Microscopy has become an invaluable tool for biological and medical research, providing high sensitivity, molecular specificity, inherent three-dimensional sub-cellular resolution and deep tissue penetration. In terms of imaging speeds, however, mechanical scanners still limit the acquisition rates to typic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15618-w
更新日期:2020-04-28 00:00:00
abstract::The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05220-6
更新日期:2018-07-24 00:00:00
abstract::While erythropoietin (EPO) constitutes the major treatment for anemia, a range of anemic disorders remain resistant to EPO treatment. The need for alternative therapeutic strategies requires the identification of mechanisms that physiologically restrain erythropoiesis. Here we show that P38α restrains erythropoiesis i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05955-2
更新日期:2018-08-29 00:00:00
abstract::Crystalline phase transitions caused by external stimuli have been used to detect physical changes in the solid-state properties. This study presents the mechanical switching of crystals of ferrocene-containing rotaxane controlled by focused laser light. The expansion and contraction of the crystals can be driven by t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13321
更新日期:2016-11-03 00:00:00
abstract::Cotton is an important natural fiber crop, however, its comprehensive and high-resolution gene map is lacking. Here we integrate four complementary high-throughput techniques, including Pacbio long read Iso-seq, strand-specific RNA-seq, CAGE-seq, and PolyA-seq, to systematically explore the transcription landscape acr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12575-x
更新日期:2019-10-17 00:00:00
abstract::Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18-25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17489-7
更新日期:2020-07-24 00:00:00
abstract::Models of visual attention postulate the existence of a saliency map whose function is to guide attention and gaze to the most conspicuous regions in a visual scene. Although cortical representations of saliency have been reported, there is mounting evidence for a subcortical saliency mechanism, which pre-dates the ev...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14263
更新日期:2017-01-24 00:00:00