Abstract:
:Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms. Here we show that the FRQ-CK1 interaction, but not FRQ stability, correlates with circadian period in Neurospora circadian clock mutants. Mutations that specifically affect the FRQ-CK1 interaction lead to severe alterations in circadian period. The FRQ-CK1 interaction has two roles in the circadian negative feedback loop. First, it determines the FRQ phosphorylation profile, which regulates FRQ stability and also feeds back to either promote or reduce the interaction itself. Second, it determines the efficiency of circadian negative feedback process by mediating FRQ-dependent WC phosphorylation. Our conclusions are further supported by mathematical modeling and in silico experiments. Together, these results suggest that the FRQ-CK1 interaction is a major rate-limiting step in circadian period determination.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Ydoi
10.1038/s41467-019-12239-wsubject
Has Abstractpub_date
2019-09-25 00:00:00pages
4352issue
1issn
2041-1723pii
10.1038/s41467-019-12239-wjournal_volume
10pub_type
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