FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora.

Abstract:

:Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms. Here we show that the FRQ-CK1 interaction, but not FRQ stability, correlates with circadian period in Neurospora circadian clock mutants. Mutations that specifically affect the FRQ-CK1 interaction lead to severe alterations in circadian period. The FRQ-CK1 interaction has two roles in the circadian negative feedback loop. First, it determines the FRQ phosphorylation profile, which regulates FRQ stability and also feeds back to either promote or reduce the interaction itself. Second, it determines the efficiency of circadian negative feedback process by mediating FRQ-dependent WC phosphorylation. Our conclusions are further supported by mathematical modeling and in silico experiments. Together, these results suggest that the FRQ-CK1 interaction is a major rate-limiting step in circadian period determination.

journal_name

Nat Commun

journal_title

Nature communications

authors

Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

doi

10.1038/s41467-019-12239-w

subject

Has Abstract

pub_date

2019-09-25 00:00:00

pages

4352

issue

1

issn

2041-1723

pii

10.1038/s41467-019-12239-w

journal_volume

10

pub_type

杂志文章
  • Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms.

    abstract::Cell identity is specified in the early mammalian embryo by the generation of precursors for two cell lineages: the pluripotent inner cell mass and differentiating trophectoderm. Here we identify Angiomotin as a key regulator of this process. We show that the loss of Angiomotin, together with Angiomotin-like 2, leads ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3251

    authors: Leung CY,Zernicka-Goetz M

    更新日期:2013-01-01 00:00:00

  • Negative Poisson's ratio in 1T-type crystalline two-dimensional transition metal dichalcogenides.

    abstract::Materials with a negative Poisson's ratio, also known as auxetic materials, exhibit unusual and counterintuitive mechanical behaviour-becoming fatter in cross-section when stretched. Such behaviour is mostly attributed to some special re-entrant or hinged geometric structures regardless of the chemical composition and...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15224

    authors: Yu L,Yan Q,Ruzsinszky A

    更新日期:2017-05-25 00:00:00

  • Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.

    abstract::Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by the HLA-Ib molecule MR1 through the exclusive use of a TRAV1-2-containing TCRα. Here we use MR1 tetramer staining and ex vivo analysis with mycobacteria-infected MR1-deficient cells to demonstrate the presence of function...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12506

    authors: Meermeier EW,Laugel BF,Sewell AK,Corbett AJ,Rossjohn J,McCluskey J,Harriff MJ,Franks T,Gold MC,Lewinsohn DM

    更新日期:2016-08-16 00:00:00

  • Shared heritability and functional enrichment across six solid cancers.

    abstract::Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise gene...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-08054-4

    authors: Jiang X,Finucane HK,Schumacher FR,Schmit SL,Tyrer JP,Han Y,Michailidou K,Lesseur C,Kuchenbaecker KB,Dennis J,Conti DV,Casey G,Gaudet MM,Huyghe JR,Albanes D,Aldrich MC,Andrew AS,Andrulis IL,Anton-Culver H,Antoniou AC

    更新日期:2019-01-25 00:00:00

  • Action boosts episodic memory encoding in humans via engagement of a noradrenergic system.

    abstract::We are constantly interacting with our environment whilst we encode memories. However, how actions influence memory formation remains poorly understood. Goal-directed movement engages the locus coeruleus (LC), the main source of noradrenaline in the brain. Noradrenaline is also known to enhance episodic encoding, sugg...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-11358-8

    authors: Yebra M,Galarza-Vallejo A,Soto-Leon V,Gonzalez-Rosa JJ,de Berker AO,Bestmann S,Oliviero A,Kroes MCW,Strange BA

    更新日期:2019-08-06 00:00:00

  • TET2 directs mammary luminal cell differentiation and endocrine response.

    abstract::Epigenetic regulation plays an important role in governing stem cell fate and tumorigenesis. Lost expression of a key DNA demethylation enzyme TET2 is associated with human cancers and has been linked to stem cell traits in vitro; however, whether and how TET2 regulates mammary stem cell fate and mammary tumorigenesis...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18129-w

    authors: Kim MR,Wu MJ,Zhang Y,Yang JY,Chang CJ

    更新日期:2020-09-15 00:00:00

  • Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions.

    abstract::Iminium catalysis, involving the transformation of iminium ions to enamines, has been extensively studied in the context of a number of organic processes. However, the reverse of this process involving conversion of enamines to iminium species has not been realized. Here, we describe a new transformation-'oxidative en...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1214

    authors: Zhang SL,Xie HX,Zhu J,Li H,Zhang XS,Li J,Wang W

    更新日期:2011-01-01 00:00:00

  • Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.

    abstract::Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2595

    authors: Inagaki H,Ohye T,Kogo H,Tsutsumi M,Kato T,Tong M,Emanuel BS,Kurahashi H

    更新日期:2013-01-01 00:00:00

  • Rats adopt the optimal timescale for evidence integration in a dynamic environment.

    abstract::Decision making in dynamic environments requires discounting old evidence that may no longer inform the current state of the world. Previous work found that humans discount old evidence in a dynamic environment, but do not discount at the optimal rate. Here we investigated whether rats can optimally discount evidence ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06561-y

    authors: Piet AT,El Hady A,Brody CD

    更新日期:2018-10-15 00:00:00

  • Live cyanobacteria produce photocurrent and hydrogen using both the respiratory and photosynthetic systems.

    abstract::Oxygenic photosynthetic organisms perform solar energy conversion of water and CO2 to O2 and sugar at a broad range of wavelengths and light intensities. These cells also metabolize sugars using a respiratory system that functionally overlaps the photosynthetic apparatus. In this study, we describe the harvesting of p...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04613-x

    authors: Saper G,Kallmann D,Conzuelo F,Zhao F,Tóth TN,Liveanu V,Meir S,Szymanski J,Aharoni A,Schuhmann W,Rothschild A,Schuster G,Adir N

    更新日期:2018-06-04 00:00:00

  • Tailoring nanoscopic confines to maximize catalytic activity of hydronium ions.

    abstract::Acid catalysis by hydronium ions is ubiquitous in aqueous-phase organic reactions. Here we show that hydronium ion catalysis, exemplified by intramolecular dehydration of cyclohexanol, is markedly influenced by steric constraints, yielding turnover rates that increase by up to two orders of magnitude in tight confines...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15442

    authors: Shi H,Eckstein S,Vjunov A,Camaioni DM,Lercher JA

    更新日期:2017-05-25 00:00:00

  • Author Correction: Hybridization is a recurrent evolutionary stimulus in wild yeast speciation.

    abstract::The original version of the Supplementary Information associated with this Article contained errors in Supplementary Figures 2, 12, 20 and 22. The HTML has been updated to include a corrected version of the Supplementary Information; the original incorrect versions of these Figures can be found as Supplementary Inform...

    journal_title:Nature communications

    pub_type: 已发布勘误

    doi:10.1038/s41467-019-09702-z

    authors: Eberlein C,Hénault M,Fijarczyk A,Charron G,Bouvier M,Kohn LM,Anderson JB,Landry CR

    更新日期:2019-05-13 00:00:00

  • Mutual synchronization of spin torque nano-oscillators through a long-range and tunable electrical coupling scheme.

    abstract::The concept of spin-torque-driven high-frequency magnetization dynamics, allows the potential construction of complex networks of non-linear dynamical nanoscale systems, combining the field of spintronics and the study of non-linear systems. In the few previous demonstrations of synchronization of several spin-torque ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15825

    authors: Lebrun R,Tsunegi S,Bortolotti P,Kubota H,Jenkins AS,Romera M,Yakushiji K,Fukushima A,Grollier J,Yuasa S,Cros V

    更新日期:2017-06-12 00:00:00

  • A gas-to-particle conversion mechanism helps to explain atmospheric particle formation through clustering of iodine oxides.

    abstract::Emitted from the oceans, iodine-bearing molecules are ubiquitous in the atmosphere and a source of new atmospheric aerosol particles of potentially global significance. However, its inclusion in atmospheric models is hindered by a lack of understanding of the first steps of the photochemical gas-to-particle conversion...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18252-8

    authors: Gómez Martín JC,Lewis TR,Blitz MA,Plane JMC,Kumar M,Francisco JS,Saiz-Lopez A

    更新日期:2020-09-09 00:00:00

  • A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome.

    abstract::Compartmentalization of the gut microbiota is thought to be important to system function, but the extent of spatial organization in the gut ecosystem remains poorly understood. Here, we profile the murine colonic microbiota along longitudinal and lateral axes using laser capture microdissection. We found fine-scale sp...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-12413-0

    authors: Riva A,Kuzyk O,Forsberg E,Siuzdak G,Pfann C,Herbold C,Daims H,Loy A,Warth B,Berry D

    更新日期:2019-09-25 00:00:00

  • Nanoscale memristive radiofrequency switches.

    abstract::Radiofrequency switches are critical components in wireless communication systems and consumer electronics. Emerging devices include switches based on microelectromechanical systems and phase-change materials. However, these devices suffer from disadvantages such as large physical dimensions and high actuation voltage...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms8519

    authors: Pi S,Ghadiri-Sadrabadi M,Bardin JC,Xia Q

    更新日期:2015-06-25 00:00:00

  • Interference between overlapping memories is predicted by neural states during learning.

    abstract::One of the primary contributors to forgetting is interference from overlapping memories. Intuitively, this suggests-and prominent theoretical models argue-that memory interference is best avoided by encoding overlapping memories as if they were unrelated. It is therefore surprising that reactivation of older memories ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13377-x

    authors: Chanales AJH,Dudukovic NM,Richter FR,Kuhl BA

    更新日期:2019-11-25 00:00:00

  • Impurity-band transport in organic spin valves.

    abstract::The central phenomenon in the field of organic spintronics is the large magnetoresistance in thick organic spin valves. A prerequisite for understanding the magnetoresistance is a reliable description of the device resistance, or the I-V characteristics. Here I show that the observed I-V characteristics in the organic...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5842

    authors: Yu ZG

    更新日期:2014-09-09 00:00:00

  • The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.

    abstract::Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms13930

    authors: Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra N

    更新日期:2017-01-27 00:00:00

  • Compound heterozygous mutations in the noncoding RNU4ATAC cause Roifman Syndrome by disrupting minor intron splicing.

    abstract::Roifman Syndrome is a rare congenital disorder characterized by growth retardation, cognitive delay, spondyloepiphyseal dysplasia and antibody deficiency. Here we utilize whole-genome sequencing of Roifman Syndrome patients to reveal compound heterozygous rare variants that disrupt highly conserved positions of the RN...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9718

    authors: Merico D,Roifman M,Braunschweig U,Yuen RK,Alexandrova R,Bates A,Reid B,Nalpathamkalam T,Wang Z,Thiruvahindrapuram B,Gray P,Kakakios A,Peake J,Hogarth S,Manson D,Buncic R,Pereira SL,Herbrick JA,Blencowe BJ,Roifman CM

    更新日期:2015-11-02 00:00:00

  • Observation of an evolving magnetic flux rope before and during a solar eruption.

    abstract::Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1753

    authors: Zhang J,Cheng X,Ding MD

    更新日期:2012-03-20 00:00:00

  • Weaker plant-enemy interactions decrease tree seedling diversity with edge-effects in a fragmented tropical forest.

    abstract::In fragmented forests, tree diversity declines near edges but the ecological processes underlying this loss of diversity remain poorly understood. Theory predicts that top-down regulation of seedling recruitment by insect herbivores and fungal pathogens contributes to maintaining tree diversity in forests, but it is u...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06997-2

    authors: Krishnadas M,Bagchi R,Sridhara S,Comita LS

    更新日期:2018-10-30 00:00:00

  • Constant-intensity waves and their modulation instability in non-Hermitian potentials.

    abstract::In all of the diverse areas of science where waves play an important role, one of the most fundamental solutions of the corresponding wave equation is a stationary wave with constant intensity. The most familiar example is that of a plane wave propagating in free space. In the presence of any Hermitian potential, a wa...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms8257

    authors: Makris KG,Musslimani ZH,Christodoulides DN,Rotter S

    更新日期:2015-07-08 00:00:00

  • Hydrothermal vent fields and chemosynthetic biota on the world's deepest seafloor spreading centre.

    abstract::The Mid-Cayman spreading centre is an ultraslow-spreading ridge in the Caribbean Sea. Its extreme depth and geographic isolation from other mid-ocean ridges offer insights into the effects of pressure on hydrothermal venting, and the biogeography of vent fauna. Here we report the discovery of two hydrothermal vent fie...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1636

    authors: Connelly DP,Copley JT,Murton BJ,Stansfield K,Tyler PA,German CR,Van Dover CL,Amon D,Furlong M,Grindlay N,Hayman N,Hühnerbach V,Judge M,Le Bas T,McPhail S,Meier A,Nakamura K,Nye V,Pebody M,Pedersen RB,Plouviez S,

    更新日期:2012-01-10 00:00:00

  • Reversible multicolor chromism in layered formamidinium metal halide perovskites.

    abstract::Metal halide perovskites feature crystalline-like electronic band structures and liquid-like physical properties. The crystal-liquid duality enables optoelectronic devices with unprecedented performance and a unique opportunity to chemically manipulate the structure with low energy input. In this work, we leverage the...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19009-z

    authors: Rosales BA,Mundt LE,Allen TG,Moore DT,Prince KJ,Wolden CA,Rumbles G,Schelhas LT,Wheeler LM

    更新日期:2020-10-16 00:00:00

  • Dynamic urea bond for the design of reversible and self-healing polymers.

    abstract::Polymers bearing dynamic covalent bonds may exhibit dynamic properties, such as self-healing, shape memory and environmental adaptation. However, most dynamic covalent chemistries developed so far require either catalyst or change of environmental conditions to facilitate bond reversion and dynamic property change in ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4218

    authors: Ying H,Zhang Y,Cheng J

    更新日期:2014-01-01 00:00:00

  • A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.

    abstract::Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory-adapted strains (mean IC50 32 nM), Ugandan field isolates (mean ex vivo IC50 64 nM), and murine P. berghei and P. falciparum infections (day 4 E...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14574

    authors: Sonoiki E,Ng CL,Lee MC,Guo D,Zhang YK,Zhou Y,Alley MR,Ahyong V,Sanz LM,Lafuente-Monasterio MJ,Dong C,Schupp PG,Gut J,Legac J,Cooper RA,Gamo FJ,DeRisi J,Freund YR,Fidock DA,Rosenthal PJ

    更新日期:2017-03-06 00:00:00

  • Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits.

    abstract::Transcriptome-wide association studies integrate gene expression data with common risk variation to identify gene-trait associations. By incorporating epigenome data to estimate the functional importance of genetic variation on gene expression, we generate a small but significant improvement in the accuracy of transcr...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-11874-7

    authors: Zhang W,Voloudakis G,Rajagopal VM,Readhead B,Dudley JT,Schadt EE,Björkegren JLM,Kim Y,Fullard JF,Hoffman GE,Roussos P

    更新日期:2019-08-23 00:00:00

  • Spin-orbit torque-assisted switching in magnetic insulator thin films with perpendicular magnetic anisotropy.

    abstract::As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque on and thereby switches the magnetization in a neighbouring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12688

    authors: Li P,Liu T,Chang H,Kalitsov A,Zhang W,Csaba G,Li W,Richardson D,DeMann A,Rimal G,Dey H,Jiang JS,Porod W,Field SB,Tang J,Marconi MC,Hoffmann A,Mryasov O,Wu M

    更新日期:2016-09-01 00:00:00

  • Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

    abstract::Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment. Because TLRs and IL-1R1 have been shown to influence the repair process of various tissues, we expl...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11051

    authors: Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

    更新日期:2016-03-22 00:00:00