Abstract:
:Angiogenesis is a necessary process for solid tumor growth. Cellular markers for endothelial cell proliferation are potential targets for identifying the vasculature of tumors in homeostasis. Here we customize the behaviors of engineered cells to recognize Apj, a surface marker of the neovascular endothelium, using synthetic Notch (synNotch) receptors. We designed apelin-based synNotch receptors (AsNRs) that can specifically interact with Apj and then stimulate synNotch pathways. Cells engineered with AsNRs have the ability to sense the proliferation of endothelial cells (ECs). Designed for different synNotch pathways, engineered cells express different proteins to respond to angiogenic signals; therefore, angiogenesis can be detected by cells engineered with AsNRs. Furthermore, T cells customized with AsNRs can sense the proliferation of vascular endothelial cells. As solid tumors generally require vascular support, AsNRs are potential tools for the detection and therapy of a variety of solid tumors in adults.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang Z,Wang F,Zhong J,Zhu T,Zheng Y,Zhao T,Xie Q,Ma F,Li R,Tang Q,Xu F,Tian X,Zhu Jdoi
10.1038/s41467-020-15729-4subject
Has Abstractpub_date
2020-05-01 00:00:00pages
2163issue
1issn
2041-1723pii
10.1038/s41467-020-15729-4journal_volume
11pub_type
杂志文章abstract::Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on genomic regions associated with human complex traits and contextualize the relationship between evolution and molecular function. Here, we develop an approach to test for signatures of diverse evolutionary forces on trait-asso...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17258-6
更新日期:2020-07-24 00:00:00
abstract::In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00452-4
更新日期:2017-09-19 00:00:00
abstract::When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17287-1
更新日期:2020-07-10 00:00:00
abstract::Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11481
更新日期:2016-05-11 00:00:00
abstract::6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08921-8
更新日期:2019-03-01 00:00:00
abstract::The history of the Earth has been marked by major ecological transitions, driven by metabolic innovation, that radically reshaped the composition of the oceans and atmosphere. The nature and magnitude of the earliest transitions, hundreds of million years before photosynthesis evolved, remain poorly understood. Using ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16374-7
更新日期:2020-06-01 00:00:00
abstract::It is generally assumed that cells interrogate the mechanical properties of their environment by pushing and pulling on the extracellular matrix (ECM). For instance, acto-myosin-dependent contraction forces exerted at focal adhesions (FAs) allow the cell to actively probe substrate elasticity. Here, we report that a s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06367-y
更新日期:2018-09-20 00:00:00
abstract::Despite being highly interdependent, the major biochemical networks of the living cell-the networks of interacting genes and of metabolic reactions, respectively-have been approached mostly as separate systems so far. Recently, a framework for interdependent networks has emerged in the context of statistical physics. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00587-4
更新日期:2017-09-14 00:00:00
abstract::Suspension-feeding fishes such as goldfish and whale sharks retain prey without clogging their oral filters, whereas clogging is a major expense in industrial crossflow filtration of beer, dairy foods and biotechnology products. Fishes' abilities to retain particles that are smaller than the pore size of the gill-rake...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11092
更新日期:2016-03-29 00:00:00
abstract::To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12394
更新日期:2016-08-03 00:00:00
abstract::Non-aromatic nitrogen- and oxygen-containing heterocycles such as piperidines and pyrans are prevalent components of natural products and pharmaceutical drugs. Although it has been a workhorse as a synthetic method for assembling unsaturated sp(2)-hybridized substrates, transition metal-catalysed cross-coupling chemis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6474
更新日期:2014-11-18 00:00:00
abstract::Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04434-y
更新日期:2018-05-17 00:00:00
abstract::Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16350-1
更新日期:2020-05-15 00:00:00
abstract::Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target to control tumor-associated macrophages. The low level FROUNT expression in patients with cancer correlates with better clinical outcomes. Frount-defici...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14338-5
更新日期:2020-01-30 00:00:00
abstract::The exceptional interest in improving the limitations of data storage, molecular electronics and optoelectronics has promoted the development of an ever increasing number of techniques used to pattern polymers at micro and nanoscale. Most of them rely on atomic force microscopy to thermally or electrostatically induce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3668
更新日期:2013-01-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15995-2
更新日期:2020-04-27 00:00:00
abstract::Many crystals, such as those of metals, can transform from one symmetry into another having lower free energy via a diffusionless transformation. Here we create binary colloidal crystals consisting of polymer microspheres, pulled together by DNA bridges, that induce specific, reversible attractions between two species...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2206
更新日期:2012-01-01 00:00:00
abstract::The advent and growth of synthetic biology has demonstrated its potential as a promising avenue of research to address many societal needs. However, plant synthetic biology efforts have been hampered by a dearth of DNA part libraries, versatile transformation vectors and efficient assembly strategies. Here, we describ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13215
更新日期:2016-10-26 00:00:00
abstract::Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating processes within complex biological assemblies. Imaging mass spectrometry (IMS) is a powerful emerging tool for mapping the spatial distribution of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13858-z
更新日期:2020-01-07 00:00:00
abstract::Liquid crystalline phases of matter permeate nature and technology, with examples ranging from cell membranes to liquid-crystal displays. Remarkably, electronic liquid-crystal phases can exist in two-dimensional electron systems (2DES) at half Landau-level filling in the quantum Hall regime. Theory has predicted the e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01810-y
更新日期:2017-11-16 00:00:00
abstract::Flexible organic memory devices are one of the integral components for future flexible organic electronics. However, high-density all-organic memory cell arrays on malleable substrates without cross-talk have not been demonstrated because of difficulties in their fabrication and relatively poor performances to date. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3707
更新日期:2013-01-01 00:00:00
abstract::Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but the generalizability of such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on the Illumina HumanExome Beadchip, in search ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3872
更新日期:2013-01-01 00:00:00
abstract::Steels belong to one of the best established materials, however, the mechanisms of various phase transformations down to the nano length scale are still not fully clear. In this work, high-resolution transmission electron microscopy is combined with atomistic simulations to study the nanoscale carbide precipitation in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06474-w
更新日期:2018-10-01 00:00:00
abstract::Because maintenance of non-scalable cellular components--membranes and chromosomes--requires an increasing fraction of energy as cell size decreases, miniaturization comes at a considerable energetic cost for a phytoplanktonic cell. Consequently, if eukaryotes can use their superior energetic resources to acquire nutr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4776
更新日期:2014-04-29 00:00:00
abstract::The separation of immiscible liquids has significant implications for magma evolution and the formation of magmatic ore deposits. We combine high-resolution imaging and electron probe microanalysis with the first use of atom probe tomography on tholeiitic basaltic glass from Hawaii, the Snake River Plain, and Iceland,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12694-5
更新日期:2019-10-23 00:00:00
abstract::Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02317-2
更新日期:2018-01-15 00:00:00
abstract::Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic integrated frequency combs (soliton microcombs) have enabled t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20404-9
更新日期:2021-01-18 00:00:00
abstract::Moiré superlattices (MSLs) are modulated structures produced from homogeneous or heterogeneous 2D layers stacked with a twist angle and/or lattice mismatch. Expanding the range of available materials, methods for fabricating MSL, and realization of unique emergent properties are key challenges. Here we report a facile...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12347-7
更新日期:2019-10-02 00:00:00
abstract::Complex oxide heterointerfaces and van der Waals heterostructures present two versatile but intrinsically different platforms for exploring emergent quantum phenomena and designing new functionalities. The rich opportunity offered by the synergy between these two classes of materials, however, is yet to be charted. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15191-2
更新日期:2020-03-17 00:00:00
abstract::In 2016 the World Health Organization identified 21 countries that could eliminate malaria by 2020. Monitoring progress towards this goal requires tracking ongoing transmission. Here we develop methods that estimate individual reproduction numbers and their variation through time and space. Individual reproduction num...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04577-y
更新日期:2018-06-26 00:00:00