Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.

abstract：:Plasmids are important members of the bacterial mobile gene pool, and are among the most important contributors to horizontal gene transfer between bacteria. They typically harbour a wide spectrum of host beneficial traits, such as antibiotic resistance, inserted into their backbones. Although these inserted elements ...

journal_title：Nature communications

authors： Norberg P,Bergström M,Jethava V,Dubhashi D,Hermansson M

更新日期：2011-01-01 00:00:00

abstract：:A superconducting state is characterized by the gap in the electronic density of states, which vanishes at the superconducting transition temperature T(c). It was discovered that in high-temperature superconductors, a noticeable depression in the density of states, the pseudogap, still remains even at temperatures abo...

journal_title：Nature communications

authors： Sacépé B,Chapelier C,Baturina TI,Vinokur VM,Baklanov MR,Sanquer M

更新日期：2010-01-01 00:00:00

abstract：:Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissu...

journal_title：Nature communications

authors： Chen F,Ma K,Madajewski B,Zhuang L,Zhang L,Rickert K,Marelli M,Yoo B,Turker MZ,Overholtzer M,Quinn TP,Gonen M,Zanzonico P,Tuesca A,Bowen MA,Norton L,Subramony JA,Wiesner U,Bradbury MS

更新日期：2018-10-08 00:00:00

abstract：:Olfactory and metabolic dysfunctions are intertwined phenomena associated with obesity and neurodegenerative diseases; yet how mechanistically olfaction regulates metabolic homeostasis remains unclear. Specificity of olfactory perception integrates diverse environmental odors and olfactory neurons expressing different...

journal_title：Nature communications

authors： Mutlu AS,Gao SM,Zhang H,Wang MC

更新日期：2020-03-19 00:00:00

abstract：:The sensitivity of quantum magnetometer is challenged by control errors and, especially in the solid state, by their short coherence times. Refocusing techniques can overcome these limitations and improve the sensitivity to periodic fields, but they come at the cost of reduced bandwidth and cannot be applied to sense ...

journal_title：Nature communications

authors： Aiello CD,Hirose M,Cappellaro P

更新日期：2013-01-01 00:00:00

abstract：:Coherence in light-matter interaction is a necessary ingredient if light is used to control the quantum state of a material system. Coherent effects are firmly associated with isolated systems kept at low temperature. The exceedingly fast dephasing in condensed matter environments, in particular at elevated temperatur...

journal_title：Nature communications

authors： Kolarczik M,Owschimikow N,Korn J,Lingnau B,Kaptan Y,Bimberg D,Schöll E,Lüdge K,Woggon U

更新日期：2013-01-01 00:00:00

abstract：:The exceptional interest in improving the limitations of data storage, molecular electronics and optoelectronics has promoted the development of an ever increasing number of techniques used to pattern polymers at micro and nanoscale. Most of them rely on atomic force microscopy to thermally or electrostatically induce...

journal_title：Nature communications

authors： Farina M,Ye T,Lanzani G,di Donato A,Venanzoni G,Mencarelli D,Pietrangelo T,Morini A,Keivanidis PE

更新日期：2013-01-01 00:00:00

abstract：:Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temperature also exhibit emergent physical phenomena and are of great promise for optoelectronic applications. Here, we demonstrate that nanostructured, multilayer transition metal dichalcogenides (TMDCs) by themselves pro...

journal_title：Nature communications

authors： Zhang H,Abhiraman B,Zhang Q,Miao J,Jo K,Roccasecca S,Knight MW,Davoyan AR,Jariwala D

更新日期：2020-07-15 00:00:00

abstract：:Leads are a key feature of the Arctic ice pack during the winter owing to their substantial contribution to the surface energy balance. According to the present understanding, enhanced heat and moisture fluxes from high lead concentrations tend to produce more boundary layer clouds. However, described here in our comp...

journal_title：Nature communications

authors： Li X,Krueger SK,Strong C,Mace GG,Benson S

更新日期：2020-01-10 00:00:00

abstract：:Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must recognize multiple ch...

journal_title：Nature communications

authors： Mindrebo JT,Patel A,Kim WE,Davis TD,Chen A,Bartholow TG,La Clair JJ,McCammon JA,Noel JP,Burkart MD

更新日期：2020-04-07 00:00:00

abstract：:Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, we used molecular dynamics simulations to monitor--at atomic an...

journal_title：Nature communications

authors： Yuan S,Filipek S,Palczewski K,Vogel H

更新日期：2014-09-09 00:00:00

abstract：:Cambodia harbours a variety of aboriginal (and presumably ancient) populations that have largely been ignored in studies of genetic diversity. Here we investigate the matrilineal gene pool of 1,054 Cambodians from 14 geographic populations. Using mitochondrial whole-genome sequencing, we identify eight new mitochondri...

journal_title：Nature communications

authors： Zhang X,Qi X,Yang Z,Serey B,Sovannary T,Bunnath L,Seang Aun H,Samnom H,Zhang H,Lin Q,van Oven M,Shi H,Su B

更新日期：2013-01-01 00:00:00

abstract：:HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investi...

journal_title：Nature communications

authors： Huang KH,Bonsall D,Katzourakis A,Thomson EC,Fidler SJ,Main J,Muir D,Weber JN,Frater AJ,Phillips RE,Pybus OG,Goulder PJ,McClure MO,Cooke GS,Klenerman P

更新日期：2010-10-19 00:00:00

abstract：:How the stressosome, the epicenter of the stress response in bacteria, transmits stress signals from the environment has remained elusive. The stressosome consists of multiple copies of three proteins RsbR, RsbS and RsbT, a kinase that is important for its activation. Using cryo-electron microscopy, we determined the ...

journal_title：Nature communications

authors： Williams AH,Redzej A,Rolhion N,Costa TRD,Rifflet A,Waksman G,Cossart P

更新日期：2019-07-08 00:00:00

abstract：:Atropisomers are important organic frameworks in bioactive natural products, drugs as well as chiral catalysts. Meanwhile, silanols display unique properties compared to their alcohol analogs, however, the catalytic synthesis of atropisomers bearing silanol groups is challenging. Here, we show a rhodium-catalyzed tors...

journal_title：Nature communications

authors： Feng J,Bi X,Xue X,Li N,Shi L,Gu Z

更新日期：2020-09-07 00:00:00

abstract：:Columnar joints form by cracking during cooling-induced contraction of lava, allowing hydrothermal fluid circulation. A lack of direct observations of their formation has led to ambiguity about the temperature window of jointing and its impact on fluid flow. Here we develop a novel thermo-mechanical experiment to disc...

journal_title：Nature communications

authors： Lamur A,Lavallée Y,Iddon FE,Hornby AJ,Kendrick JE,von Aulock FW,Wadsworth FB

更新日期：2018-04-12 00:00:00

abstract：:Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency of somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Treatment of relapsed aGCT remains a significant clinical challenge. Here we show, using whole-exome and cancer gene panel sequencing of 79 aGCTs from t...

journal_title：Nature communications

authors： Hillman RT,Celestino J,Terranova C,Beird HC,Gumbs C,Little L,Nguyen T,Thornton R,Tippen S,Zhang J,Lu KH,Gershenson DM,Rai K,Broaddus RR,Futreal PA

更新日期：2018-06-27 00:00:00

abstract：:The Dansgaard-Oeschger (DO) events, as observed in oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record, are an outstanding example of past abrupt climate transitions. Their physical cause remains debated, and previous research indicated that they are not preceded by classical early-warning s...

journal_title：Nature communications

authors： Boers N

更新日期：2018-07-02 00:00:00

abstract：:There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...

journal_title：Nature communications

authors： Taylor JL,Debost JPG,Morton SU,Wigdor EM,Heyne HO,Lal D,Howrigan DP,Bloemendal A,Larsen JT,Kosmicki JA,Weiner DJ,Homsy J,Seidman JG,Seidman CE,Agerbo E,McGrath JJ,Mortensen PB,Petersen L,Daly MJ,Robinson EB

更新日期：2019-07-10 00:00:00

abstract：:Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Salmonellae and Mycobacterium tuberculosis (Mtb) exploit host pathways t...

journal_title：Nature communications

authors： Korbee CJ,Heemskerk MT,Kocev D,van Strijen E,Rabiee O,Franken KLMC,Wilson L,Savage NDL,Džeroski S,Haks MC,Ottenhoff THM

更新日期：2018-01-24 00:00:00

abstract：:The efficiency of an heat engine is traditionally defined as the ratio of its average output work over its average input heat. Its highest possible value was discovered by Carnot in 1824 and is a cornerstone concept in thermodynamics. It led to the discovery of the second law and to the definition of the Kelvin temper...

journal_title：Nature communications

authors： Verley G,Esposito M,Willaert T,Van den Broeck C

更新日期：2014-09-15 00:00:00

abstract：:One of the fundamental challenges in nanophotonics is to gain full control over nanoscale optical elements. The precise spatiotemporal arrangement determines their interactions and collective behavior. To this end, DNA nanotechnology is employed as an unprecedented tool to create nanophotonic devices with excellent sp...

journal_title：Nature communications

authors： Xin L,Zhou C,Duan X,Liu N

更新日期：2019-11-27 00:00:00

abstract：:The fracture toughness of glassy materials remains poorly understood. In large part, this is due to the disordered, intrinsically non-equilibrium nature of the glass structure, which challenges its theoretical description and experimental determination. We show that the notch fracture toughness of metallic glasses exh...

journal_title：Nature communications

authors： Ketkaew J,Chen W,Wang H,Datye A,Fan M,Pereira G,Schwarz UD,Liu Z,Yamada R,Dmowski W,Shattuck MD,O'Hern CS,Egami T,Bouchbinder E,Schroers J

更新日期：2018-08-16 00:00:00

abstract：:Thymocyte-expressed, positive selection-associated 1 (Tespa1) is important in T cell receptor (TCR)-driven thymocyte development. Downstream of the TCR, Tespa1 is a crucial component of the linker for activation of T cells (LAT) signalosome, facilitating calcium signalling and subsequent MAPK activation. However, it i...

journal_title：Nature communications

authors： Liang J,Lyu J,Zhao M,Li D,Zheng M,Fang Y,Zhao F,Lou J,Guo C,Wang L,Wang D,Liu W,Lu L

更新日期：2017-06-09 00:00:00

abstract：:The interface between LaAlO(3) and SrTiO(3) possesses a range of intriguing properties, notably a proposed connection between the surface state of the LaAlO(3) and the conductivity buried in the SrTiO(3). Here we study the effect of the surface adsorption of a variety of common laboratory solvents on the conductivity ...

journal_title：Nature communications

authors： Xie Y,Hikita Y,Bell C,Hwang HY

更新日期：2011-10-11 00:00:00

abstract：:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid th...

journal_title：Nature communications

authors： Tabatabaei SK,Wang B,Athreya NBM,Enghiad B,Hernandez AG,Fields CJ,Leburton JP,Soloveichik D,Zhao H,Milenkovic O

更新日期：2020-04-08 00:00:00

abstract：:The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

journal_title：Nature communications

authors： Van de Water K,Sterckx YG,Volkov AN

更新日期：2015-05-06 00:00:00

abstract：:Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs). Such interactions, which seem to be independent of viral envelope glycoprotein g...

journal_title：Nature communications

authors： Yu X,Feizpour A,Ramirez NG,Wu L,Akiyama H,Xu F,Gummuluru S,Reinhard BM

更新日期：2014-06-20 00:00:00

abstract：:Structural rearrangements govern the various properties of disordered systems and visualization of these dynamical processes can provide critical information on structural deformation and phase transformation of the systems. However, direct imaging of individual atoms or molecules in a disordered state is quite challe...

journal_title：Nature communications

authors： Choe J,Lee Y,Park J,Kim Y,Kim CU,Kim K

更新日期：2019-09-27 00:00:00

abstract：:Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflammation and repair. In the lung, non-alveolar RTM, called interstitial macrophages (IM), importantly contribute to tissue homeostasis but remain little characterized. Here we show, using single-cell RNA-sequencing (scRNA-...

journal_title：Nature communications

authors： Schyns J,Bai Q,Ruscitti C,Radermecker C,De Schepper S,Chakarov S,Farnir F,Pirottin D,Ginhoux F,Boeckxstaens G,Bureau F,Marichal T

更新日期：2019-09-03 00:00:00