Control of electronic conduction at an oxide heterointerface using surface polar adsorbates.

abstract：:Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed rec-YnH, a new yeast two and three-hybrid-based screening pipeline capable of detecting interact...

journal_title：Nature communications

authors： Yang JS,Garriga-Canut M,Link N,Carolis C,Broadbent K,Beltran-Sastre V,Serrano L,Maurer SP

更新日期：2018-09-14 00:00:00

abstract：:Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...

journal_title：Nature communications

authors： Jin L,Feng X,Rong H,Pan Z,Inaba Y,Qiu L,Zheng W,Lin S,Wang R,Wang Z,Wang S,Liu H,Li S,Xie W,Li Y

更新日期：2013-01-01 00:00:00

abstract：:The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a regio...

journal_title：Nature communications

authors： Duffy DL,Zhu G,Li X,Sanna M,Iles MM,Jacobs LC,Evans DM,Yazar S,Beesley J,Law MH,Kraft P,Visconti A,Taylor JC,Liu F,Wright MJ,Henders AK,Bowdler L,Glass D,Ikram MA,Uitterlinden AG,Madden PA,Heath AC,Nelson EC,

更新日期：2018-11-14 00:00:00

abstract：:The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution fea...

journal_title：Nature communications

authors： Libertini E,Heath SC,Hamoudi RA,Gut M,Ziller MJ,Czyz A,Ruotti V,Stunnenberg HG,Frontini M,Ouwehand WH,Meissner A,Gut IG,Beck S

更新日期：2016-06-27 00:00:00

abstract：:Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the...

journal_title：Nature communications

authors： Gavish A,Shwartz A,Weizman A,Schejter E,Shilo BZ,Barkai N

更新日期：2016-02-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Mattesen TB,Rasmussen MH,Sandoval J,Ongen H,Árnadóttir SS,Gladov J,Martinez-Cardus A,de Moura MC,Madsen AH,Laurberg S,Dermitzakis ET,Esteller M,Andersen CL,Bramsen JB

更新日期：2020-06-03 00:00:00

abstract：:Proteins are co-translationally inserted into the bacterial plasma membrane via the SecYEG translocon by lateral release of hydrophobic transmembrane segments into the phospholipid bilayer. The trigger for lateral opening of the translocon is not known. Here we monitor lateral opening by photo-induced electron transfe...

journal_title：Nature communications

authors： Ge Y,Draycheva A,Bornemann T,Rodnina MV,Wintermeyer W

更新日期：2014-10-15 00:00:00

abstract：:Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxa...

journal_title：Nature communications

authors： Rodrigues DC,Harvey EM,Suraj R,Erickson SL,Mohammad L,Ren M,Liu H,He G,Kaplan DR,Ellis J,Yang G

更新日期：2020-04-24 00:00:00

abstract：:Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis....

journal_title：Nature communications

authors： Lara J,Diacovich L,Trajtenberg F,Larrieux N,Malchiodi EL,Fernández MM,Gago G,Gramajo H,Buschiazzo A

更新日期：2020-07-24 00:00:00

abstract：:Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...

journal_title：Nature communications

authors： Kehayias P,Jarmola A,Mosavian N,Fescenko I,Benito FM,Laraoui A,Smits J,Bougas L,Budker D,Neumann A,Brueck SRJ,Acosta VM

更新日期：2017-08-04 00:00:00

abstract：:Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests. Animals and humans with HHL have normal auditory thresholds but defective cochlear neurotransmission, that is, reduced suprathresh...

journal_title：Nature communications

authors： Wan G,Corfas G

更新日期：2017-02-17 00:00:00

abstract：:Hybridomas, fusions of primary mouse B cells and myelomas, are stable, rapidly-proliferating cell lines widely utilized for antibody screening and production. Antibody specificity of a hybridoma clone is determined by the immunoglobulin sequence of the primary B cell. Here we report a platform for rapid reprogramming ...

journal_title：Nature communications

authors： Pogson M,Parola C,Kelton WJ,Heuberger P,Reddy ST

更新日期：2016-08-17 00:00:00

abstract：:Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of e...

journal_title：Nature communications

authors： Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,Näslund E,Ylä-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Y

更新日期：2016-08-05 00:00:00

abstract：:Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment. Because TLRs and IL-1R1 have been shown to influence the repair process of various tissues, we expl...

journal_title：Nature communications

authors： Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

更新日期：2016-03-22 00:00:00

abstract：:Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in several other NRs, but f...

journal_title：Nature communications

authors： Huang W,Peng Y,Kiselar J,Zhao X,Albaqami A,Mendez D,Chen Y,Chakravarthy S,Gupta S,Ralston C,Kao HY,Chance MR,Yang S

更新日期：2018-08-30 00:00:00

abstract：:The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...

journal_title：Nature communications

authors： Mihnev MT,Kadi F,Divin CJ,Winzer T,Lee S,Liu CH,Zhong Z,Berger C,de Heer WA,Malic E,Knorr A,Norris TB

更新日期：2016-05-25 00:00:00

abstract：:Cavity quantum electrodynamics describes the fundamental interactions between light and matter, and how they can be controlled by shaping the local environment. For example, optical microcavities allow high-efficiency detection and manipulation of single atoms. In this regime, fluctuations of atom number are on the or...

journal_title：Nature communications

authors： Goldwin J,Trupke M,Kenner J,Ratnapala A,Hinds EA

更新日期：2011-08-09 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are modulators of the immune system. In experimental models, HDACi are particularly potent against malignancies originating from the B-lymphocyte lineage. Here we examine...

journal_title：Nature communications

authors： Waibel M,Christiansen AJ,Hibbs ML,Shortt J,Jones SA,Simpson I,Light A,O'Donnell K,Morand EF,Tarlinton DM,Johnstone RW,Hawkins ED

更新日期：2015-04-27 00:00:00

abstract：:Vortices play a crucial role in determining the properties of superconductors as well as their applications. Therefore, characterization and manipulation of vortices, especially at the single-vortex level, is of great importance. Among many techniques to study single vortices, scanning tunnelling microscopy (STM) stan...

journal_title：Nature communications

authors： Ge JY,Gladilin VN,Tempere J,Xue C,Devreese JT,Van de Vondel J,Zhou Y,Moshchalkov VV

更新日期：2016-12-09 00:00:00

abstract：:Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein...

journal_title：Nature communications

authors： Schulte L,Mao J,Reitz J,Sreeramulu S,Kudlinzki D,Hodirnau VV,Meier-Credo J,Saxena K,Buhr F,Langer JD,Blackledge M,Frangakis AS,Glaubitz C,Schwalbe H

更新日期：2020-11-04 00:00:00

abstract：:The RNA-binding protein Roquin is required to prevent autoimmunity. Roquin controls T-helper cell activation and differentiation by limiting the induced expression of costimulatory receptors such as tumor necrosis factor receptor superfamily 4 (Tnfrs4 or Ox40). A constitutive decay element (CDE) with a characteristic ...

journal_title：Nature communications

authors： Janowski R,Heinz GA,Schlundt A,Wommelsdorf N,Brenner S,Gruber AR,Blank M,Buch T,Buhmann R,Zavolan M,Niessing D,Heissmeyer V,Sattler M

更新日期：2016-03-24 00:00:00

abstract：:Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity is essential for BLM recruitment in early phase, it is dispensab...

journal_title：Nature communications

authors： Tripathi V,Agarwal H,Priya S,Batra H,Modi P,Pandey M,Saha D,Raghavan SC,Sengupta S

更新日期：2018-03-09 00:00:00

abstract：:Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominan...

journal_title：Nature communications

authors： Bufe B,Teuchert Y,Schmid A,Pyrski M,Pérez-Gómez A,Eisenbeis J,Timm T,Ishii T,Lochnit G,Bischoff M,Mombaerts P,Leinders-Zufall T,Zufall F

更新日期：2019-10-25 00:00:00

abstract：:Homologous recombination-based gene targeting is a powerful tool for precise genome modification and has been widely used in organisms ranging from yeast to higher organisms such as Drosophila and mouse. However, gene targeting in higher plants, including the most widely used model plant Arabidopsis thaliana, remains ...

journal_title：Nature communications

authors： Miki D,Zhang W,Zeng W,Feng Z,Zhu JK

更新日期：2018-05-17 00:00:00

abstract：:The original version of the Supplementary Information associated with this Article contained errors in Supplementary Figures 2, 12, 20 and 22. The HTML has been updated to include a corrected version of the Supplementary Information; the original incorrect versions of these Figures can be found as Supplementary Inform...

journal_title：Nature communications

authors： Eberlein C,Hénault M,Fijarczyk A,Charron G,Bouvier M,Kohn LM,Anderson JB,Landry CR

更新日期：2019-05-13 00:00:00

abstract：:Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...

journal_title：Nature communications

authors： Mammoto A,Mammoto T,Kanapathipillai M,Wing Yung C,Jiang E,Jiang A,Lofgren K,Gee EP,Ingber DE

更新日期：2013-01-01 00:00:00

abstract：:Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable processes....

journal_title：Nature communications

authors： Bertolani A,Pirrie L,Stefan L,Houbenov N,Haataja JS,Catalano L,Terraneo G,Giancane G,Valli L,Milani R,Ikkala O,Resnati G,Metrangolo P

更新日期：2015-06-30 00:00:00

abstract：:Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10(-9)) but not males (P=0.71). This association with IS ...

journal_title：Nature communications

authors： Sharma S,Londono D,Eckalbar WL,Gao X,Zhang D,Mauldin K,Kou I,Takahashi A,Matsumoto M,Kamiya N,Murphy KK,Cornelia R,TSRHC Scoliosis Clinical Group.,Japan Scoliosis Clinical Research Group.,Herring JA,Burns D,Ahituv N,Ike

更新日期：2015-03-18 00:00:00

abstract：:Physical and electrochemical phenomena at the surfaces of transition metal oxides and their coupling to local functionality remains one of the enigmas of condensed matter physics. Understanding the emergent physical phenomena at surfaces requires the capability to probe the local composition, map order parameter field...

journal_title：Nature communications

authors： Gai Z,Lin W,Burton JD,Fuchigami K,Snijders PC,Ward TZ,Tsymbal EY,Shen J,Jesse S,Kalinin SV,Baddorf AP

更新日期：2014-07-24 00:00:00

abstract：:Co-expression analysis is widely used to predict gene function and to identify functionally related gene sets. However, co-expression analysis using human cancer transcriptomic data is confounded by somatic copy number alterations (SCNA), which produce co-expression signatures based on physical proximity rather than b...

journal_title：Nature communications

authors： Cai L,Li Q,Du Y,Yun J,Xie Y,DeBerardinis RJ,Xiao G

更新日期：2017-12-19 00:00:00