Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour.

Abstract:

:Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominantly present in the signal sequence of the bacterial protein MgrB, a highly conserved regulator of virulence and antibiotic resistance in Enterobacteriaceae. MgrB peptide can be produced and secreted by bacteria, and is selectively recognized by a subset of VSNs. Exposure to the peptide also stimulates VSNs in freely behaving mice and drives innate avoidance. Our data shows that Fpr3 is required for neuronal detection and avoidance of peptides derived from a conserved master virulence regulator of enteric bacteria.

journal_name

Nat Commun

journal_title

Nature communications

authors

Bufe B,Teuchert Y,Schmid A,Pyrski M,Pérez-Gómez A,Eisenbeis J,Timm T,Ishii T,Lochnit G,Bischoff M,Mombaerts P,Leinders-Zufall T,Zufall F

doi

10.1038/s41467-019-12842-x

subject

Has Abstract

pub_date

2019-10-25 00:00:00

pages

4889

issue

1

issn

2041-1723

pii

10.1038/s41467-019-12842-x

journal_volume

10

pub_type

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