Publisher Correction: MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer.

abstract：:Generation and recombination of electrons and holes in organic solar cells occurs via charge transfer states located at the donor/acceptor interface. The energy of these charge transfer states is a crucial factor for the attainable open-circuit voltage and its correct determination is thus of utmost importance for a d...

journal_title：Nature communications

authors： List M,Sarkar T,Perkhun P,Ackermann J,Luo C,Würfel U

更新日期：2018-09-07 00:00:00

abstract：:Machines that simultaneously process and store multistate data at one and the same location can provide a new class of fast, powerful and efficient general-purpose computers. We demonstrate the central element of an all-optical calculator, a photonic abacus, which provides multistate compute-and-store operation by int...

journal_title：Nature communications

authors： Feldmann J,Stegmaier M,Gruhler N,Ríos C,Bhaskaran H,Wright CD,Pernice WHP

更新日期：2017-11-02 00:00:00

abstract：:As the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the f...

journal_title：Nature communications

authors： Davy M,Shi Z,Park J,Tian C,Genack AZ

更新日期：2015-04-20 00:00:00

abstract：:A key question of theoretical ecology is which properties of ecosystems favour their stability and help maintaining biodiversity. This question recently reconsidered mutualistic systems, generating intense controversy about the role of mutualistic interactions and their network architecture. Here we show analytically ...

journal_title：Nature communications

authors： Pascual-García A,Bastolla U

更新日期：2017-02-24 00:00:00

abstract：:Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), whic...

journal_title：Nature communications

authors： Wei Y,Wang D,Jin F,Bian Z,Li L,Liang H,Li M,Shi L,Pan C,Zhu D,Chen X,Hu G,Liu Y,Zhang CY,Zen K

更新日期：2017-01-09 00:00:00

abstract：:Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectric...

journal_title：Nature communications

authors： Zillikens MC,Demissie S,Hsu YH,Yerges-Armstrong LM,Chou WC,Stolk L,Livshits G,Broer L,Johnson T,Koller DL,Kutalik Z,Luan J,Malkin I,Ried JS,Smith AV,Thorleifsson G,Vandenput L,Hua Zhao J,Zhang W,Aghdassi A,Åkesson

更新日期：2017-07-19 00:00:00

abstract：:The electron deficiency and strong bonding capacity of boron have led to a vast variety of molecular structures in chemistry and materials science. Here we report the observation of highly symmetric cobalt-centered boron drum-like structures of CoB16(-), characterized by photoelectron spectroscopy and ab initio calcul...

journal_title：Nature communications

authors： Popov IA,Jian T,Lopez GV,Boldyrev AI,Wang LS

更新日期：2015-10-12 00:00:00

abstract：:Cortical neurons are often functionally heterogeneous even for molecularly defined subtypes. In sensory cortices, physiological responses to natural stimuli can be sparse and vary widely even for neighboring neurons. It is thus difficult to parse out circuits that encode specific stimuli for further experimentation. H...

journal_title：Nature communications

authors： Tasaka GI,Guenthner CJ,Shalev A,Gilday O,Luo L,Mizrahi A

更新日期：2018-02-28 00:00:00

abstract：:Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis...

journal_title：Nature communications

authors： Xu P,Gu Q,Wang W,Wong L,Bower AG,Collins CH,Koffas MA

更新日期：2013-01-01 00:00:00

abstract：:Magnetic resonance spectroscopy is one of the most important tools in chemical and bio-medical research. However, sensitivity limitations typically restrict imaging resolution to ~ 10 µm. Here we bring quantum control to the detection of chemical systems to demonstrate high-resolution electron spin imaging using the q...

journal_title：Nature communications

authors： Simpson DA,Ryan RG,Hall LT,Panchenko E,Drew SC,Petrou S,Donnelly PS,Mulvaney P,Hollenberg LCL

更新日期：2017-09-06 00:00:00

abstract：:Chloride intracellular channel 4 (CLIC4) is a mammalian homologue of EXC-4 whose mutation is associated with cystic excretory canals in nematodes. Here we show that CLIC4-null mouse embryos exhibit impaired renal tubulogenesis. In both developing and developed kidneys, CLIC4 is specifically enriched in the proximal tu...

journal_title：Nature communications

authors： Chou SY,Hsu KS,Otsu W,Hsu YC,Luo YC,Yeh C,Shehab SS,Chen J,Shieh V,He GA,Marean MB,Felsen D,Ding A,Poppas DP,Chuang JZ,Sung CH

更新日期：2016-01-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Macreadie PI,Anton A,Raven JA,Beaumont N,Connolly RM,Friess DA,Kelleway JJ,Kennedy H,Kuwae T,Lavery PS,Lovelock CE,Smale DA,Apostolaki ET,Atwood TB,Baldock J,Bianchi TS,Chmura GL,Eyre BD,Fourqurean JW,Hall-Spencer J

更新日期：2019-11-08 00:00:00

abstract：:Eurasian continent has experienced cold winters over the past two decades in contrast with Arctic warming. Previous studies have suggested that the cold Eurasian winters are associated with Arctic sea-ice loss, while others attributed them to atmospheric internal variability. However, here we show that the Arctic and ...

journal_title：Nature communications

authors： Matsumura S,Kosaka Y

更新日期：2019-08-01 00:00:00

abstract：:Phase separation of specific biomolecules into liquid droplet-like condensates is a key mechanism to form membrane-less organelles, which spatio-temporally organize diverse biochemical processes in cells. To investigate the working principles of these biomolecular condensates as dynamic reaction centers, precise contr...

journal_title：Nature communications

authors： Hong K,Song D,Jung Y

更新日期：2020-11-03 00:00:00

abstract：:The fossil record of crocodylians and their relatives (pseudosuchians) reveals a rich evolutionary history, prompting questions about causes of long-term decline to their present-day low biodiversity. We analyse climatic drivers of subsampled pseudosuchian biodiversity over their 250 million year history, using a comp...

journal_title：Nature communications

authors： Mannion PD,Benson RBJ,Carrano MT,Tennant JP,Judd J,Butler RJ

更新日期：2015-09-24 00:00:00

abstract：:The complex transport processes contributing to sintering are not yet fully understood, partially because in-situ observations of sintering in three dimensions (3D) are very difficult. Here we report a novel experiment in which monocrystalline copper spheres are first marked with microscopic boreholes drilled using a ...

journal_title：Nature communications

authors： Grupp R,Nöthe M,Kieback B,Banhart J

更新日期：2011-01-01 00:00:00

abstract：:The engineering of nanoscale features enables the properties of solid-state materials to be tuned. Here, we show the tunable preparation of cuprous sulfide nanocrystals ranging in internal structures from single-domain to multi-domain. The synthetic method utilizes in-situ oxidation to grow nanocrystals with a control...

journal_title：Nature communications

authors： Gong J,Jain PK

更新日期：2019-07-23 00:00:00

abstract：:WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hi...

journal_title：Nature communications

authors： Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V

更新日期：2019-04-02 00:00:00

abstract：:A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters macrophage cytokine...

journal_title：Nature communications

authors： Singh KS,Leu JI,Barnoud T,Vonteddu P,Gnanapradeepan K,Lin C,Liu Q,Barton JC,Kossenkov AV,George DL,Murphy ME,Dotiwala F

更新日期：2020-01-24 00:00:00

abstract：:Inbreeding typically reduces fitness. Related partners may fail to reproduce and any inbred offspring may die early or fail to reproduce themselves. Here we show that inbreeding causes early death in the zebra finch Taeniopygia guttata, and among inbred individuals of the same inbreeding coefficient (F), those that di...

journal_title：Nature communications

authors： Hemmings NL,Slate J,Birkhead TR

更新日期：2012-05-29 00:00:00

abstract：:Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequencing data such as t...

journal_title：Nature communications

authors： Mandric I,Rotman J,Yang HT,Strauli N,Montoya DJ,Van Der Wey W,Ronas JR,Statz B,Yao D,Petrova V,Zelikovsky A,Spreafico R,Shifman S,Zaitlen N,Rossetti M,Ansel KM,Eskin E,Mangul S

更新日期：2020-06-19 00:00:00

abstract：:Profound global loss of DNA methylation is a hallmark of many cancers. One potential consequence of this is the reactivation of transposable elements (TEs) which could stimulate the immune system via cell-intrinsic antiviral responses. Here, we develop REdiscoverTE, a computational method for quantifying genome-wide T...

journal_title：Nature communications

authors： Kong Y,Rose CM,Cass AA,Williams AG,Darwish M,Lianoglou S,Haverty PM,Tong AJ,Blanchette C,Albert ML,Mellman I,Bourgon R,Greally J,Jhunjhunwala S,Chen-Harris H

更新日期：2019-11-19 00:00:00

abstract：:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...

journal_title：Nature communications

authors： Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LM

更新日期：2018-09-19 00:00:00

abstract：:A phase transition is often accompanied by the appearance of an order parameter and symmetry breaking. Certain magnetic materials exhibit exotic hidden-order phases, in which the order parameters are not directly accessible to conventional magnetic measurements. Thus, experimental identification and theoretical unders...

journal_title：Nature communications

authors： Shen Y,Liu C,Qin Y,Shen S,Li YD,Bewley R,Schneidewind A,Chen G,Zhao J

更新日期：2019-10-08 00:00:00

abstract：:The study of multicellular development is grounded in two complementary domains: cell biomechanics, which examines how physical forces shape the embryo, and genetic regulation and molecular signalling, which concern how cells determine their states and behaviours. Integrating both sides into a unified framework is cru...

journal_title：Nature communications

authors： Delile J,Herrmann M,Peyriéras N,Doursat R

更新日期：2017-01-23 00:00:00

abstract：:The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N's function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of MavC in complex wi...

journal_title：Nature communications

authors： Wang Y,Zhan Q,Wang X,Li P,Liu S,Gao G,Gao P

更新日期：2020-06-02 00:00:00

abstract：:Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to function as competitive endogenous RNAs (ceRNAs) by sponging specific microRNAs. Here, we report the first spatially resolved cellular expr...

journal_title：Nature communications

authors： Kristensen LS,Ebbesen KK,Sokol M,Jakobsen T,Korsgaard U,Eriksen AC,Hansen TB,Kjems J,Hager H

更新日期：2020-09-11 00:00:00

abstract：:BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis. It is believed that mutations in genes such as TRP53 allow BRCA2 heterozygous cells to overcome growth arrest when they ...

journal_title：Nature communications

authors： Biswas K,Philip S,Yadav A,Martin BK,Burkett S,Singh V,Babbar A,North SL,Chang S,Sharan SK

更新日期：2018-02-07 00:00:00

abstract：:The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...

journal_title：Nature communications

authors： Zhang Y,Jiao Y,Liu Z,Zhu YX

更新日期：2015-01-29 00:00:00

abstract：:The energy-level alignment of molecular transistors can be controlled by external gating to move molecular orbitals with respect to the Fermi levels of the source and drain electrodes. Two-terminal molecular tunnelling junctions, however, lack a gate electrode and suffer from Fermi-level pinning, making it difficult t...

journal_title：Nature communications

authors： Yuan L,Franco C,Crivillers N,Mas-Torrent M,Cao L,Sangeeth CSS,Rovira C,Veciana J,Nijhuis CA

更新日期：2016-07-26 00:00:00