Abstract：
:Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflammation and repair. In the lung, non-alveolar RTM, called interstitial macrophages (IM), importantly contribute to tissue homeostasis but remain little characterized. Here we show, using single-cell RNA-sequencing (scRNA-seq), two phenotypically distinct subpopulations of long-lived monocyte-derived IM, i.e. CD206+ and CD206-IM, as well as a discrete population of extravasating CD64+CD16.2+ monocytes. CD206+ IM are peribronchial self-maintaining RTM that constitutively produce high levels of chemokines and immunosuppressive cytokines. Conversely, CD206-IM preferentially populate the alveolar interstitium and exhibit features of antigen-presenting cells. In addition, our data support that CD64+CD16.2+ monocytes arise from intravascular Ly-6Clo patrolling monocytes that enter the tissue at steady-state to become putative precursors of CD206-IM. This study expands our knowledge about the complexity of lung IM and reveals an ontogenic pathway for one IM subset, an important step for elaborating future macrophage-targeted therapies.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Schyns J,Bai Q,Ruscitti C,Radermecker C,De Schepper S,Chakarov S,Farnir F,Pirottin D,Ginhoux F,Boeckxstaens G,Bureau F,Marichal Tdoi
10.1038/s41467-019-11843-0subject
Has Abstractpub_date
2019-09-03 00:00:00pages
3964issue
1issn
2041-1723pii
10.1038/s41467-019-11843-0journal_volume
10pub_type
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