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The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation.

Abstract：

:How the stressosome, the epicenter of the stress response in bacteria, transmits stress signals from the environment has remained elusive. The stressosome consists of multiple copies of three proteins RsbR, RsbS and RsbT, a kinase that is important for its activation. Using cryo-electron microscopy, we determined the atomic organization of the Listeria monocytogenes stressosome at 3.38 Å resolution. RsbR and RsbS are organized in a 60-protomers truncated icosahedron. A key phosphorylation site on RsbR (T209) is partially hidden by an RsbR flexible loop, whose "open" or "closed" position could modulate stressosome activity. Interaction between three glutamic acids in the N-terminal domain of RsbR and the membrane-bound mini-protein Prli42 is essential for Listeria survival to stress. Together, our data provide the atomic model of the stressosome core and highlight a loop important for stressosome activation, paving the way towards elucidating the mechanism of signal transduction by the stressosome in bacteria.

journal_name

Nat Commun

journal_title

Nature communications

authors

Williams AH,Redzej A,Rolhion N,Costa TRD,Rifflet A,Waksman G,Cossart P

doi

10.1038/s41467-019-10782-0

subject

Has Abstract

pub_date

2019-07-08 00:00:00

pages

3005

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10782-0

journal_volume

10

pub_type

杂志文章

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