Atlantic multi-decadal oscillation covaries with Agulhas leakage.

abstract：:Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8(+) T cells requires cortical thymic epithelial cells that express β5t-cont...

journal_title：Nature communications

authors： Sasaki K,Takada K,Ohte Y,Kondo H,Sorimachi H,Tanaka K,Takahama Y,Murata S

更新日期：2015-06-23 00:00:00

abstract：:The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient het...

journal_title：Nature communications

authors： Desai N,Neyaz A,Szabolcs A,Shih AR,Chen JH,Thapar V,Nieman LT,Solovyov A,Mehta A,Lieb DJ,Kulkarni AS,Jaicks C,Xu KH,Raabe MJ,Pinto CJ,Juric D,Chebib I,Colvin RB,Kim AY,Monroe R,Warren SE,Danaher P,Reeves JW,

更新日期：2020-12-09 00:00:00

abstract：:Huntington's Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defec...

journal_title：Nature communications

authors： Gomez-Pastor R,Burchfiel ET,Neef DW,Jaeger AM,Cabiscol E,McKinstry SU,Doss A,Aballay A,Lo DC,Akimov SS,Ross CA,Eroglu C,Thiele DJ

更新日期：2017-02-13 00:00:00

abstract：:Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (A...

journal_title：Nature communications

authors： Kim JY,Bai Y,Jayne LA,Hector RD,Persaud AK,Ong SS,Rojesh S,Raj R,Feng MJHH,Chung S,Cianciolo RE,Christman JW,Campbell MJ,Gardner DS,Baker SD,Sparreboom A,Govindarajan R,Singh H,Chen T,Poi M,Susztak K,Cobb SR,P

更新日期：2020-04-21 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2020-01-14 00:00:00

abstract：:Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, th...

journal_title：Nature communications

authors： Adachi K,Enoki T,Kawano Y,Veraz M,Nakai H

更新日期：2014-01-01 00:00:00

abstract：:It has been observed that concentrated solutions of short DNA oligomers develop liquid crystal ordering as the result of a hierarchically structured supramolecular self-assembly. In mixtures of oligomers with various degree of complementarity, liquid crystal microdomains are formed via the selective aggregation of tho...

journal_title：Nature communications

authors： Fraccia TP,Smith GP,Zanchetta G,Paraboschi E,Yi Y,Walba DM,Dieci G,Clark NA,Bellini T

更新日期：2015-03-10 00:00:00

abstract：:CD36 transmembrane proteins have diverse roles in lipid uptake, cell adhesion and pathogen sensing. Despite numerous in vitro studies, how they act in native cellular contexts is poorly understood. A Drosophila CD36 homologue, sensory neuron membrane protein 1 (SNMP1), was previously shown to facilitate detection of l...

journal_title：Nature communications

authors： Gomez-Diaz C,Bargeton B,Abuin L,Bukar N,Reina JH,Bartoi T,Graf M,Ong H,Ulbrich MH,Masson JF,Benton R

更新日期：2016-06-15 00:00:00

abstract：:The ter region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in Escherichia coli. Delayed segregation is controlled by the MatP protein, which binds to specific sites (matS) within ter, and interacts with other proteins such as ZapB. Here, we investigate t...

journal_title：Nature communications

authors： Crozat E,Tardin C,Salhi M,Rousseau P,Lablaine A,Bertoni T,Holcman D,Sclavi B,Cicuta P,Cornet F

更新日期：2020-07-30 00:00:00

abstract：:Thermal conductivity of two-dimensional (2D) materials is of interest for energy storage, nanoelectronics and optoelectronics. Here, we report that the thermal conductivity of molybdenum disulfide can be modified by electrochemical intercalation. We observe distinct behaviour for thin films with vertically aligned bas...

journal_title：Nature communications

authors： Zhu G,Liu J,Zheng Q,Zhang R,Li D,Banerjee D,Cahill DG

更新日期：2016-10-21 00:00:00

abstract：:In the original version of this Article, the affiliation details for Antoine Aze, Michalis Fragkos, Stéphane Bocquet, Julien Cau and Marcel Méchali incorrectly omitted 'CNRS and the University of Montpellier'. This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Aze A,Fragkos M,Bocquet S,Cau J,Méchali M

更新日期：2018-02-05 00:00:00

abstract：:The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. He...

journal_title：Nature communications

authors： Araiz C,Yan A,Bettedi L,Samuelson I,Virtue S,McGavigan AK,Dani C,Vidal-Puig A,Foukas LC

更新日期：2019-04-04 00:00:00

abstract：:Approximately half of the world's population lives in the tropics, and future changes in the hydrological cycle will impact not just the freshwater supplies but also energy production in areas dependent upon hydroelectric power. It is vital that we understand the mechanisms/processes that affect tropical precipitation...

journal_title：Nature communications

authors： Winter A,Zanchettin D,Miller T,Kushnir Y,Black D,Lohmann G,Burnett A,Haug GH,Estrella-Martínez J,Breitenbach SF,Beaufort L,Rubino A,Cheng H

更新日期：2015-07-14 00:00:00

abstract：:Batesian mimicry, in which harmless species (mimics) deter predators by deceitfully imitating the warning signals of noxious species (models), generates striking cases of phenotypic convergence that are classic examples of evolution by natural selection. However, mimicry of venomous coral snakes has remained controver...

journal_title：Nature communications

authors： Davis Rabosky AR,Cox CL,Rabosky DL,Title PO,Holmes IA,Feldman A,McGuire JA

更新日期：2016-05-05 00:00:00

abstract：:Understanding the resilience of aquatic ectothermic animals to climate warming has been hindered by the absence of experimental systems experiencing warming across relevant timescales (for example, decades). Here, we examine European perch (Perca fluviatilis, L.) from the Biotest enclosure, a unique coastal ecosystem ...

journal_title：Nature communications

authors： Sandblom E,Clark TD,Gräns A,Ekström A,Brijs J,Sundström LF,Odelström A,Adill A,Aho T,Jutfelt F

更新日期：2016-05-17 00:00:00

abstract：:Metal-support interaction is of great significance for catalysis as it can induce charge transfer between metal and support, tame electronic structure of supported metals, impact adsorption energy of reaction intermediates, and eventually change the catalytic performance. Here, we report the metal size-dependent charg...

journal_title：Nature communications

authors： Yan QQ,Wu DX,Chu SQ,Chen ZQ,Lin Y,Chen MX,Zhang J,Wu XJ,Liang HW

更新日期：2019-10-31 00:00:00

abstract：:Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs). Such interactions, which seem to be independent of viral envelope glycoprotein g...

journal_title：Nature communications

authors： Yu X,Feizpour A,Ramirez NG,Wu L,Akiyama H,Xu F,Gummuluru S,Reinhard BM

更新日期：2014-06-20 00:00:00

abstract：:How electronic charge is distributed over a molecule determines to a large extent its chemical properties. Here, we demonstrate how the electrostatic force field, originating from the inhomogeneous charge distribution in a molecule, can be measured with submolecular resolution. We exploit the fact that distortions typ...

journal_title：Nature communications

authors： Hapala P,Švec M,Stetsovych O,van der Heijden NJ,Ondráček M,van der Lit J,Mutombo P,Swart I,Jelínek P

更新日期：2016-05-27 00:00:00

abstract：:Scenarios that limit global warming to below 2 °C by 2100 assume significant land-use change to support large-scale carbon dioxide (CO2) removal from the atmosphere by afforestation/reforestation, avoided deforestation, and Biomass Energy with Carbon Capture and Storage (BECCS). The more ambitious mitigation scenarios...

journal_title：Nature communications

authors： Harper AB,Powell T,Cox PM,House J,Huntingford C,Lenton TM,Sitch S,Burke E,Chadburn SE,Collins WJ,Comyn-Platt E,Daioglou V,Doelman JC,Hayman G,Robertson E,van Vuuren D,Wiltshire A,Webber CP,Bastos A,Boysen L,Ciais

更新日期：2018-08-07 00:00:00

abstract：:Intentional doping is the core of semiconductor technologies to tune electrical and optical properties of semiconductors for electronic devices, however, it has shown to be a grand challenge for halide perovskites. Here, we show that some metal ions, such as silver, strontium, cerium ions, which exist in the precursor...

journal_title：Nature communications

authors： Lin Y,Shao Y,Dai J,Li T,Liu Y,Dai X,Xiao X,Deng Y,Gruverman A,Zeng XC,Huang J

更新日期：2021-01-04 00:00:00

abstract：:Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is ge...

journal_title：Nature communications

authors： Kachuri L,Johansson M,Rashkin SR,Graff RE,Bossé Y,Manem V,Caporaso NE,Landi MT,Christiani DC,Vineis P,Liu G,Scelo G,Zaridze D,Shete SS,Albanes D,Aldrich MC,Tardón A,Rennert G,Chen C,Goodman GE,Doherty JA,Bickebö

更新日期：2020-01-07 00:00:00

abstract：:The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N's function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of MavC in complex wi...

journal_title：Nature communications

authors： Wang Y,Zhan Q,Wang X,Li P,Liu S,Gao G,Gao P

更新日期：2020-06-02 00:00:00

abstract：:FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae--Erg26p, Homo sapiens--NSDHL (NAD(P)...

journal_title：Nature communications

authors： Helliwell SB,Karkare S,Bergdoll M,Rahier A,Leighton-Davis JR,Fioretto C,Aust T,Filipuzzi I,Frederiksen M,Gounarides J,Hoepfner D,Hofmann A,Imbert PE,Jeker R,Knochenmuss R,Krastel P,Margerit A,Memmert K,Miault CV,Rao

更新日期：2015-10-12 00:00:00

abstract：:The original version of this Article contained an error in the third sentence of the penultimate paragraph of the 'Definition of the harmonic phase' section of the Results, which incorrectly read 'In the Coulomb phase the tensor S αβ (q) has one zero and two degenerate eigenvalues and it may be represented by an infin...

journal_title：Nature communications

authors： Bramwell ST

更新日期：2018-04-16 00:00:00

abstract：:Evidence from animal and human studies has suggested that the amygdala plays a role in detecting threat and in directing attention to the eyes. Nevertheless, there has been no systematic investigation of whether the amygdala specifically facilitates attention to the eyes or whether other features can also drive attent...

journal_title：Nature communications

authors： Dal Monte O,Costa VD,Noble PL,Murray EA,Averbeck BB

更新日期：2015-12-14 00:00:00

abstract：:Inorganic perovskites such as CsPbX3 (X=Cl, Br, I) have attracted attention due to their excellent thermal stability and high photoluminescence quantum efficiency. However, the electroluminescence quantum efficiency of their light-emitting diodes was <1%. We posited that this low efficiency was a result of high leakag...

journal_title：Nature communications

authors： Zhang L,Yang X,Jiang Q,Wang P,Yin Z,Zhang X,Tan H,Yang YM,Wei M,Sutherland BR,Sargent EH,You J

更新日期：2017-06-07 00:00:00

abstract：:The burial of terrestrial organic carbon (terrOC) in marine sediments contributes to the regulation of atmospheric CO2 on geological timescales and may mitigate positive feedback to present-day climate warming. However, the fate of terrOC in marine settings is debated, with uncertainties regarding its degradation duri...

journal_title：Nature communications

authors： Bröder L,Tesi T,Andersson A,Semiletov I,Gustafsson Ö

更新日期：2018-02-23 00:00:00

abstract：:Improved measurement techniques are central to technological development and foundational scientific exploration. Quantum physics relies on detectors sensitive to non-classical features of systems, enabling precise tests of physical laws and quantum-enhanced technologies including precision measurement and secure comm...

journal_title：Nature communications

authors： Cooper M,Karpiński M,Smith BJ

更新日期：2014-07-14 00:00:00

abstract：:Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...

journal_title：Nature communications

authors： Leyton DL,Johnson MD,Thapa R,Huysmans GH,Dunstan RA,Celik N,Shen HH,Loo D,Belousoff MJ,Purcell AW,Henderson IR,Beddoe T,Rossjohn J,Martin LL,Strugnell RA,Lithgow T

更新日期：2014-06-26 00:00:00

abstract：:In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore requires the ability of the cells to avoid the consequences of such exposure to the stressors. Here we show that orthotopic transplantation of a CD44 variant is...

journal_title：Nature communications

authors： Yae T,Tsuchihashi K,Ishimoto T,Motohara T,Yoshikawa M,Yoshida GJ,Wada T,Masuko T,Mogushi K,Tanaka H,Osawa T,Kanki Y,Minami T,Aburatani H,Ohmura M,Kubo A,Suematsu M,Takahashi K,Saya H,Nagano O

更新日期：2012-06-06 00:00:00