Abstract:
:Oocyte-specific miRNA function remains unclear in mice and worms because loss of Dgcr8 and Dicer from mouse and worm oocytes, respectively, does not yield oogenic defects. These data lead to several models: (a) miRNAs are not generated in oocytes; (b) miRNAs are generated but do not perform an oogenic function; (c) functional oocyte miRNAs are generated in a manner independent of these enzymes. Here, we test these models using a combination of genomic, expression and functional analyses on the C. elegans germline. We identify a repertoire of at least twenty-three miRNAs that accumulate in four spatial domains in oocytes. Genetic tests demonstrate that oocyte-expressed miRNAs regulate key oogenic processes within their respective expression domains. Unexpectedly, we find that over half of the oocyte-expressed miRNAs are generated through an unknown Drosha independent mechanism. Thus, a functional miRNA repertoire generated via Drosha dependent and independent pathways regulates C. elegans oocyte development.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Minogue AL,Tackett MR,Atabakhsh E,Tejada G,Arur Sdoi
10.1038/s41467-018-07791-wsubject
Has Abstractpub_date
2018-12-14 00:00:00pages
5318issue
1issn
2041-1723pii
10.1038/s41467-018-07791-wjournal_volume
9pub_type
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